A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

  • Giulietta S Monasso (Creator)
  • Thanh T Hoang (Creator)
  • Giulia Mancano (Creator)
  • Sílvia Fernández-Barrés (Creator)
  • John F Dou (Creator)
  • Vincent W V Jaddoe (Creator)
  • Christian M Page (Creator)
  • Laura Johnson (Creator)
  • Mariona Bustamante (Creator)
  • Kelly M. Bakulski (Creator)
  • Siri Eldevik Håberg (Creator)
  • Per M. Ueland (Creator)
  • Thomas Battram (Creator)
  • Simon K Merid (Creator)
  • Erik Melén (Creator)
  • Doretta Caramaschi (Creator)
  • Leanne K. Küpers (Creator)
  • Jordi Sunyer (Creator)
  • Wenche Nystad (Creator)
  • Sandra G Heil (Creator)
  • Rebecca J Schmidt (Creator)
  • Martine Vrijheid (Creator)
  • Gemma C Sharp (Creator)
  • Stephanie J London (Creator)
  • Janine F Felix (Creator)

Dataset

Description

Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value
Date made available2023
PublisherTaylor & Francis

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