Data from: Epigenome-wide association study of lung function level and its change

  • Medea Imboden (Creator)
  • Matthias Wielscher (Creator)
  • Faisal I Rezwan (Creator)
  • Andre F S Amaral (Creator)
  • Emmanuel Schaffner (Creator)
  • Ayoung Jeong (Creator)
  • Anna Beckmeyer-Borowko (Creator)
  • Sarah E Harris (Creator)
  • John M Starr (Creator)
  • Ian J Deary (Creator)
  • Claudia Flexeder (Creator)
  • Melanie Waldenberger (Creator)
  • Annette Peters (Creator)
  • Holger Schulz (Creator)
  • Su Chen (Creator)
  • Shadia Khan Sunny (Creator)
  • Wilfried J J Karmaus (Creator)
  • Yu Jiang (Creator)
  • Gertraud Erhart (Creator)
  • Florian Kronenberg (Creator)
  • Ryan Arathimos (Creator)
  • Gemma C Sharp (Creator)
  • Alex Henderson (Creator)
  • Yu Fu (Creator)
  • Päivi Piirilä (Creator)
  • Kirsi H Pietiläinen (Creator)
  • Miina Ollikainen (Creator)
  • Asa Johannson (Creator)
  • Ulf Gyllensten (Creator)
  • Maaike de Vries (Creator)
  • Diana A. van der Plaat (Creator)
  • Kim de Jong (Creator)
  • Hendrike Marike Boezen (Creator)
  • Ian P Hall (Creator)
  • Martin D Tobin (Creator)
  • Marjo-Riitta Järvelin (Creator)
  • John W Holloway (Creator)
  • Deborah Jarvis (Creator)
  • Nicole M Probst-Hensch (Creator)



Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P
Date made available2019
Geographical coverageEUROPE

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