Data from: Predicting the effects of parasite co-infection across species boundaries

  • Joanne Lello (Contributor)
  • Susan J. McClure (Contributor)
  • Kerri Tyrrell (Contributor)
  • Mark E. Viney (Contributor)

Dataset

Description

It is normal for hosts to be coinfected by parasites. Interactions among coinfecting species can have profound consequences, including changing parasite transmission dynamics, altering disease severity, and confounding attempts at parasite control. Despite the importance of coinfection, there is currently no way to predict how different parasite species may interact with one another, nor the consequences of those interactions. Here we demonstrate a method that enables such prediction by identifying two nematode parasite groups based on taxonomy and characteristics of parasitological niche. From an understanding of the interactions between the two defined groups in one host system (wild rabbits), we predict how two different nematode species, from the same defined groups, will interact in coinfections in a different host system (sheep), and then we test this experimentally. We show that as predicted, in coinfections, the blood-feeding nematode Haemonchus contortus suppresses aspects of the sheep immune response, thereby facilitating the establishment and / or survival of the nematode Trichostrongylus colubriformis; and that the T. colubriformis-induced immune response negatively affects H. contortus. This work is the first to use empirical data from one host system to successfully predict the specific outcome of a different coinfection in a second host species. The study therefore takes the first step in defining a practical framework for predicting interspecific parasite interactions in other animal systems.,Trichostrongylus worm countsData of Trichostrongylus colubriformis adult worm counts through time post initial infection in individual singly infected and Haemonchus contortus coinfected sheep.JLello_Data_S8_Trichostrongyluswormcounts_ESM.csvHaemonchus worm countsHaemonchus contortus adult and arrested larval worm counts through time since first infection in individual singly infected sheep and sheep coinfected with Trichostrongylus colubriformis.JLello_Data_S9_Haemonchuswormcounts_ESM.csvJejunal histologyJejunal histology - cell counts and scores per villus crypt unit, through time, from individual sheep from four treatment groups. Uninfected controls, infected with Haemonchus contortus only, infected with Trichostrongylus retortaeformis only or coinfected with both parasites.JLello_Data_S10_Jejunalhistology_ESM.csvAbomasal histologyAbomasal histology - cell counts and scores per villus crypt unit, through time, from individual sheep from four treatment groups. Uninfected controls, infected with Haemonchus contortus only, infected with Trichostrongylus retortaeformis only or coinfected with both parasites.JLello_Data_S11_Abomasalhistology_ESM.csvAnti-Trichostrongylus IgG1 titresAnti-Trichostrongylus IgG1 titre through time for individual sheep from three groups, uninfected controls, singly infected with Trichostrongylus colubriformis or coinfected with Trichostrongylus colubriformis and Haemonchus contortusJLello_Data_S12_AntiTrichostrongylusIgG1_ESM.csvAnti-Haemonchus IgG1 titresAnti-Haemonchus contortus IgG1 titre through time for individual sheep from three groups, 1) uninfected controls, 2) singly infected with Haemonchus contortus or 3) coinfected with Haemonchus contortus and Trichostrongylus colubriformis.JLello_Data_S13_AntiHaemonchusIgG1_ESM.csv,
Date made available22 Feb 2018
PublisherDryad

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