Pneumococcal serotypes colonise the nasopharynx in children at different densities



These data are results of a cross sectional study of nasopharyngeal bacterial colonisation of a group of healthy pre-school children from Coimbra, Portugal who had nasal swabs taken at nursery school in March 2011. The swabs were analysed by real time quantitative PCR for S. pneumoniae using primers specific to the pneumococcal gene (LytA) for autolysin. In addition samples in which S. pneumoniae was detected underwent microarray analysis for different capsular gene loci, permitting detection of one or more serotypes in each sample and their relative abundance when there were more than one.
Combining these results permitted us to report for the first time that there are apparent differences in the density of colonisation of the nasopharynx according to the serotype.

The data repository contains the raw data of the study to be published in PLOS One in 2016.
Paper title: “Pneumococcal serotypes colonise the nasopharynx in children at different densities”
Authors: Fernanda Rodrigues, Leon Danon, Begonia Morales-Aza, Paulina Sikora, Valtyr Thors, Muriel Ferreira, Katherine Gould, Jason Hinds, Adam Finn

There is a single data file named “Combined_SP_PCR_Age.csv” in CSV format.
The file entitled "todos_documentos.pdf" contains a copy of the information sheet, consent form, and questionnaire for collection of clinical details (NB: these are in Portuguese).
Date made available15 Sept 2016
PublisherUniversity of Bristol


  • Pneumococcus
  • density
  • serotype
  • carriage
  • children

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