Illumina Array

Facility/equipment: Facility

  • Location

    Bristol Bioresource Laboratories

    Oakfield House

    Bristol

    BS8 2BN

    United Kingdom

Research Output

  • 29 Article (Academic Journal)
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Article (Academic Journal)
2018

A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Barker, E. D., Walton, E., Cecil, C. A. M., Rowe, R., Jaffee, S. R., Maughan, B., O'Connor, T. G., Stringaris, A., Meehan, A. J., McArdle, W., Relton, C. L. & Gaunt, T. R., Sep 2018, In : Child Development. 89, 5, p. 1839-1855 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
210 Downloads (Pure)

DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival

Ambatipudi, S., Langdon, R., Richmond, R. C., Suderman, M., Koestler, D. C., Kelsey, K. T., Kazmi, N., Penfold, C., Ho, K. M., McArdle, W., Ring, S. M., Pring, M., Waterboer, T., Pawlita, M., Gaunt, T. R., Davey Smith, G., Thomas, S., Ness, A. R. & Relton, C. L., 1 Oct 2018, In : Oral Oncology. 85, p. 87-94 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
222 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
240 Downloads (Pure)

Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

Cuellar-Partida, G., Laurin, C., Ring, S., Gaunt, T., McRae, A., Visscher, P. M., Montgomery, G., Martin, N. G., Hemani, G., Suderman, M., Relton, C., Davey Smith, G. & Evans, D., Aug 2018, In : Human Molecular Genetics. 27, 16, p. 2927-2939 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
217 Downloads (Pure)

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

Ye, J., Richardson, T. G., McArdle, W. L., Relton, C. L., Gillespie, K. M., Suderman, M. & Hemani, G., 1 Sep 2018, In : Journal of Autoimmunity. 93, p. 66-75 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
187 Downloads (Pure)

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

Barker, E. D., Cecil, C. A. M., Walton, E., Houtepen, L. C., O'Connor, T. G., Danese, A., Jaffee, S. R., Jensen, S. K. G., Pariante, C., McArdle, W., Gaunt, T. R., Relton, C. L. & Roberts, S., Aug 2018, In : Development and Psychopathology. 30, 3, p. 1145-1156 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
287 Downloads (Pure)

Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study

Cecil, C. A. M., Walton, E., Jaffee, S. R., O'Connor, T., Maughan, B., Relton, C. L., Smith, R. G., McArdle, W., Gaunt, T. R., Ouellet-Morin, I. & Barker, E. D., 1 May 2018, In : Development and Psychopathology. p. 383-397 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
343 Downloads (Pure)
Open Access
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14 Citations (Scopus)
216 Downloads (Pure)
2017

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Felix, J. F., Joubert, B. R., Baccarelli, A. A., Sharp, G. C., Almqvist, C., Annesi-Maesano, I., Arshad, H., Baïz, N., Bakermans-Kranenburg, M. J., Bakulski, K. M., Binder, E. B., Bouchard, L., Breton, C. V., Brunekreef, B., Brunst, K. J., Burchard, E. G., Bustamante, M., Chatzi, L., Cheng Munthe-Kaas, M., Corpeleijn, E. & 104 others, Czamara, D., Dabelea, D., Davey Smith, G., De Boever, P., Duijts, L., Dwyer, T., Eng, C., Eskenazi, B., Everson, T. M., Falahi, F., Fallin, M. D., Farchi, S., Fernandez, M. F., Gao, L., Gaunt, T. R., Ghantous, A., Gillman, M. W., Gonseth, S., Grote, V., Gruzieva, O., Håberg, S. E., Herceg, Z., Hivert, M-F., Holland, N., Holloway, J. W., Hoyo, C., Hu, D., Huang, R-C., Huen, K., Järvelin, M-R., Jima, D. D., Just, A. C., Karagas, M. R., Karlsson, R., Karmaus, W., Kechris, K. J., Kere, J., Kogevinas, M., Koletzko, B., Koppelman, G. H., Küpers, L. K., Ladd-Acosta, C., Lahti, J., Lambrechts, N., Langie, S. A. S., Lie, R. T., Liu, A. H., Magnus, M. C., Magnus, P., Maguire, R. L., Marsit, C. J., McArdle, W., Melén, E., Melton, P., Murphy, S. K., Nawrot, T. S., Nisticò, L., Nohr, E. A., Nordlund, B., Nystad, W., Oh, S. S., Oken, E., Page, C. M., Perron, P., Pershagen, G., Pizzi, C., Plusquin, M., Raikkonen, K., Reese, S. E., Reischl, E., Richiardi, L., Ring, S., Roy, R. P., Rzehak, P., Schoeters, G., Schwartz, D. A., Sebert, S., Snieder, H., Sørensen, T. I. A., Starling, A. P., Sunyer, J., Taylor, J. A., Tiemeier, H., Ullemar, V., Vafeiadi, M., Van Ijzendoorn, M. H., Vonk, J. M., Vriens, A., Vrijheid, M., Wang, P., Wiemels, J. L., Wilcox, A. J., Wright, R. J., Xu, C-J., Xu, Z., Yang, I. V., Yousefi, P., Zhang, H., Zhang, W., Zhao, S., Agha, G., Relton, C. L., Jaddoe, V. W. V. & London, S. J., 13 Sep 2017, In : International Journal of Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
173 Downloads (Pure)

Distinct DNA methylation profiles in subtypes of orofacial cleft

Sharp, G., Ho, K., Davies, A., Stergiakouli, E., Humphries, K., McArdle, W., Sandy, J., Davey Smith, G., Lewis, S. & Relton, C., 8 Jun 2017, In : Clinical Epigenetics. 9, 63, 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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29 Citations (Scopus)
214 Downloads (Pure)
Open Access
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25 Citations (Scopus)
179 Downloads (Pure)

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems

Rijlaarsdam, J., Cecil, C. A. M., Walton, E., Mesirow, M. S. C., Relton, C. L., Gaunt, T. R., McArdle, W. & Barker, E. D., Jan 2017, In : Journal of Child Psychology and Psychiatry. 58, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
39 Citations (Scopus)
290 Downloads (Pure)

The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort

Simpkin, A., Howe, L., Tilling, K., Gaunt, T., Lyttleton, O., McArdle, W., Ring, S., Horvath, S., Davey Smith, G. & Relton, C., Apr 2017, In : International Journal of Epidemiology. 46, 2, p. 549-558 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
30 Citations (Scopus)
213 Downloads (Pure)

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress

Milaniak, I., Cecil, C. A. M., Barker, E. D., Relton, C., Gaunt, T., McArdle, W. & Jaffee, S. R., Dec 2017, In : Development and Psychopathology. 29, 5, p. 1663-1674 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
228 Downloads (Pure)
2016

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication

Rijlaarsdam, J., Pappa, I., Walton, E., Bakermans-Kranenburg, M. J., Mileva-Seitz, V. R., Rippe, R. C. A., Roza, S. J., Jaddoe, V. W. V., Verhulst, F. C., Felix, J. F., Cecil, C. A. M., Relton, C. L., Gaunt, T. R., McArdle, W., Mill, J., Barker, E. D., Tiemeier, H. & van IJzendoorn, M. H., Feb 2016, In : Epigenetics. 11, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
33 Citations (Scopus)
227 Downloads (Pure)

Collapsed Methylation Quantitative Trait Loci analysis for Low Frequency and Rare variants

Richardson, T., Shihab, H., Hemani, G., Zheng, J., Hannon, E., Mill, J., Carnero-Montoro, E., Bell, J. T., Lyttleton, O., McArdle, W., Ring, S., Rodriguez, S., Campbell, C., Davey Smith, G., Relton, C., Timpson, N. & Gaunt, T., 1 Oct 2016, In : Human Molecular Genetics. 25, 19, p. 4339-4349 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
314 Downloads (Pure)

DNA methylation and body mass index: investigating identified methylation sites at HIF3A in a causal framework

Richmond, R. C., Sharp, G. C., Ward, M. E., Fraser, A., Lyttleton, O., McArdle, W. L., Ring, S. M., Gaunt, T. R., Lawlor, D. A., Smith, G. D. & Relton, C. L., May 2016, In : Diabetes. 65, 5, p. 1231-1244 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
59 Citations (Scopus)
223 Downloads (Pure)

DNA methylation and substance use risk: A prospective, genome-wide study spanning gestation to adolescence

Cecil, C. A. M., Walton, E., Viding, E., McCrory, E. J., Relton, C. L., Suderman, M. J., Pingault, J-B., McArdle, W. L., Gaunt, T. R., Mill, J. & Barker, E., Dec 2016, In : Translational Psychiatry. 6, 12, 9 p., e976.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
25 Citations (Scopus)
320 Downloads (Pure)

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Joubert, BR., Felix, JF., Yousefi, P., Bakulski, KM., Just, AC., Breton, C., Reese, S. E., Markunas, CA., Richmond, R. C., Xu, C-J., Kupers, L. K., Oh, SS., Hoyo, C., Gruzieva, O., Söderhäll, C., Salas, LA., Baïz, N., Zhang, H., Lepeule, J., Ruiz, C. & 86 others, Ligthart, S., Wang, T., Taylor, JA., Duijts, L., Sharp, G. C., Jankipersadsing, SA., Nilsen, RM., Vaez, A., Fallin, M. D., Hu, D., Litonjua, AA., Fuemmeler, BF., Huen, K., Kere, J., Kull, I., Munthe-Kaas, MC., Gehring, U., Bustamante, M., Saurel-Coubizolles, MJ., Quraishi, BM., Ren, J., Tost, J., Gonzalez, JR., Peters, MJ., Håberg, SE., Xu, Z., van Meurs, JB., Gaunt, T. R., Kerkhof, M., Corpeleijn, E., Feinberg, AP., Eng, C., Baccarelli, AA., Benjamin Neelon, SE., Bradman, A., Merid, SK., Bergström, A., Herceg, Z., Hernandez-Vargas, H., Brunekreef, B., Pinart, M., Heude, B., Ewart, S., Yao, J., Lemonnier, N., Franco, OH., Wu, MC., Hofman, A., McArdle, W. L., Van der Vlies, P., Falahi, F., Gillman, MW., Barcellos, LF., Kumar, A., Wickman, M., Guerra, S., Charles, M-A., Holloway, J., Auffray, C., Tiemeier, HW., Davey Smith, G., Postma, D., Hivert, M-F., Eskenazi, B., Vrijheid, M., Arshad, H., Antó, JM., Dehghan, A., Karmaus, W., Annesi-Maesano, I., Sunyer, J., Ghantous, A., Pershagen, G., Holland, N., Murphy, SK., DeMeo, DL., Burchard, EG., Ladd-Acosta, C., Snieder, H., Nystad, W., Koppelman, GH., Relton, C. L., Jaddoe, VW. V., Wilcox, A., Melén, E. & London, SJ., 7 Apr 2016, In : American Journal of Human Genetics. 98, 4, p. 680-696 17 p.

Research output: Contribution to journalArticle (Academic Journal)

305 Citations (Scopus)

Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies

Simpkin, A. J., Hemani, G., Suderman, M., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Sharp, G. C., Tilling, K., Horvath, S., Kunze, S., Peters, A., Waldenberger, M., Ward-Caviness, C., Nohr, E. A., Sorensen, T., Relton, C. L. & Smith, G. D., 1 Jan 2016, In : Human Molecular Genetics. 25, 1, p. 191-201 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
73 Citations (Scopus)
258 Downloads (Pure)

Systematic identification of genetic influences on methylation across the human life course

Gaunt, T., Shihab, H., Hemani, G., Min, J., Woodward, G., Lyttleton, O., Zheng, J., Duggirala, A., McArdle, W., Ho, K., Ring, S., Evans, D., Davey Smith, G. & Relton, C., 31 Mar 2016, In : Genome Biology. 17, 14 p., 61.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
242 Downloads (Pure)
2015

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)

Relton, C. L., Gaunt, T., McArdle, W., Ho, K., Duggirala, A., Shihab, H., Woodward, G., Lyttleton, O., Evans, D. M., Reik, W., Paul, Y-L., Ficz, G., Ozanne, S. E., Wipat, A., Flanagan, K., Lister, A., Heijmans, B. T., Ring, S. M. & Davey Smith, G., 19 May 2015, In : International Journal of Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

100 Citations (Scopus)

Longitudinal analysis of DNA methylation associated with birth weight and gestational age

Simpkin, A. J., Suderman, M., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Tilling, K., Smith, G. D. & Relton, C. L., 13 Apr 2015, In : Human Molecular Genetics. 24, 13, p. 3752-3763 12 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Lymphoblastoid cell lines reveal associations of adult DNA methylation with childhood and current adversity that are distinct from whole blood associations

Suderman, M., Pappas, J. J., Borghol, N., Buxton, J. L., McArdle, W. L., Ring, S. M., Hertzman, C., Power, C., Szyf, M. & Pembrey, M., Aug 2015, In : International Journal of Epidemiology. 44, 4, p. 1331-40 10 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)
114 Citations (Scopus)

Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age

Lee, K. W. K., Richmond, R., Hu, P., French, L., Shin, J., Bourdon, C., Reischl, E., Waldenberger, M., Zeilinger, S., Gaunt, T., McArdle, W., Ring, S., Woodward, G., Bouchard, L., Gaudet, D., Smith, G. D., Relton, C., Paus, T. & Pausova, Z., 1 Jan 2015, In : Environmental Health Perspectives. 123, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle (Academic Journal)

100 Citations (Scopus)

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Richmond, R. C., Simpkin, A. J., Woodward, G., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Smith, A. D. A. C., Timpson, N. J., Tilling, K., Davey Smith, G. & Relton, C. L., 15 Apr 2015, In : Human Molecular Genetics. 24, 8, p. 2201-2217 16 p.

Research output: Contribution to journalArticle (Academic Journal)

176 Citations (Scopus)
2014

Differences in smoking associated DNA methylation patterns in South Asians and Europeans

Elliott, H. R., Tillin, T., McArdle, W. L., Ho, K., Duggirala, A., Frayling, T. M., Smith, G. D., Hughes, A. D., Chaturvedi, N. & Relton, C. L., 3 Feb 2014, In : Clinical Epigenetics. 6, 1, p. 4

Research output: Contribution to journalArticle (Academic Journal)

122 Citations (Scopus)

Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci

Buxton, J. L., Suderman, M., Pappas, J. J., Borghol, N., McArdle, W., Blakemore, A. I. F., Hertzman, C., Power, C., Szyf, M. & Pembrey, M., 14 May 2014, In : Scientific Reports. 4, 8 p., 4954.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
35 Citations (Scopus)
307 Downloads (Pure)