Biological and Archaeological Chemistry

  • United Kingdom

Organization profile

Organisation profile

Biological chemistry at Bristol utilises methods across computational, synthetic, analytical and biophysical chemistry to address contemporary problems in chemical biology and the archaeological sciences, as well breaking new ground in the emerging field of synthetic biology.

Specific research areas include: understanding fundamental biomolecular processes that lead to macromolecular folding and assembly, small molecule-protein interactions, and enzyme catalysis; the design of new peptide-based assemblies and materials for biomedical applications; the synthesis of carbohydrate-coated nanoparticles for bioimaging; the engineering of polyketide synthases to drive discovery of new pharmaceuticals and agrochemicals; and the application of mass spectrometry to study human prehistory.

This work is underpinned by exceptional facilities for synthesis, molecular biology, biological spectroscopy, high-performance computing, mass spectrometry, and advanced microscopy.

Many of the chemists working in this area at Bristol are founding members of cross-University centres, including the Cabot Institute for studies into environmental change; the Bristol Polyketide Group; and the Synthetic Biology Research Centre, BrisSynBio.

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    Research Output

    A Bioinspired Strategy for the Enantioselective Synthesis of Bicyclic Oxygen Heterocycles

    Rodriguez Venegas, E. & Willis, C. L., 16 Mar 2020, In : Organic Letters. 5 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Accurate compound-specific 14C dating of archaeological pottery vessels

    Casanova, E. J. A., Knowles, T. D. J., Bayliss, A., Dunne, J. B., Baranski, M. Z., Denaire, A., Lefranc, P., di Lernia, S., Roffet-Salque, M., Smyth, J., Barclay, A., Gillard, T., Claβe, E., Coles, B., Ilett, M., Jeunesse, C., Krueger, M., Marciniak, A., Minnitt, S., Rotunno, R. & 5 others, van de Velde, P., van Wijk, I., Cotton, J., Daykin, A. & Evershed, R. P., 23 Apr 2020, In : Nature. 580, p. 506–510 5 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

    Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In : Acta Neuropathologica. 18 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
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    Projects

    Student theses

    Augmenting photosynthesis to enhance crop productivity using carbon dots

    Author: Swift, T., 23 Jan 2019

    Supervisor: Galan, C. (Supervisor) & Whitney, H. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Compound-specific radiocarbon dating of lipid residues preserved in archaeological pottery vessels

    Author: Casanova, E., 23 Jan 2019

    Supervisor: Evershed, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Computational design, construction, and characterisation of artificial peroxidases

    Author: Jenkins, J., 19 Mar 2019

    Supervisor: Anderson, R. (Supervisor) & Mulholland, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Prizes

    Royal Society Wolfson Research Merit Award

    Jeremy Harvey (Recipient), 2014

    Prize: Prizes, Medals, Awards and Grants

  • Activities

    Goldschmidt Virtual 2020

    Tugba Isik (Participant), , Heather L Buss (Participant), & Ian D Bull (Participant)

    26 Jun 2020

    Activity: Participating in or organising an event typesParticipation in conference

    Inaugural Bristol BioDesign Institute Conference

    Kathleen R Sedgley (Participant), , Dek Woolfson (Organiser), , Imre Berger (Organiser), , Katharina Landfester (Keynote/plenary speaker), & Nadrian Seeman (Keynote/plenary speaker)

    10 May 2018

    Activity: Participating in or organising an event typesParticipation in conference

    File

    Computationally Directed Protein Design Workshop

    Dek Woolfson (Participant), , Fabio Parmeggiani (Participant), , Ross Anderson (Participant), , Kathleen Sedgley (Participant), & Tom Bowker (Participant)

    2018

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course