Organization profile

Organisation profile

Approximately 7,000 patients in the UK develop primary brain cancer, but there are many more who develop secondary cancer within the brain from different primary sites around the body (such as breast and lung). One of the major problems with primary brain cancer is that it invades the brain widely as single cells and therefore can be difficult to completely remove by surgery. It also can develop resistance to traditional chemotherapy and therefore tumour relapse is common.

The Brain Tumour Research group aims to involve fully understanding each individual’s tumour according to what is driving the abnormal growth of that specific tumour. Then surgery and a range of therapies can be tailored to the individual, providing a personalised medicine approach.

We collaborate with a range of groups including Brain Tumour Research Charities, neuro-oncologists, neurosurgeons, neurologists and Bristol Genetics Laboratory. We are proud to have patient representation on our Brain Tumour Bank committee. The group cell lines recently featured on the cover of Nature Reviews Clinical Oncology 2012.

Our projects and collaborations include:

  • Studies into the molecular genetics and biomarkers of brain tumours
  • Abnormal pathways driving brain and spinal cord tumours
  • Neuroradiology studies using metabolite profiles with NMR to predict tumour behaviour 
  • Convection enhanced delivery to improve drug delivery to tumours among many other

Fingerprint Dive into the research topics where Brain Tumour Centre is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

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    Research Output

    • 35 Article (Academic Journal)
    • 2 Review article (Academic Journal)
    • 1 Letter (Academic Journal)

    A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours

    Adams, C. L., Ercolano, E., Ferluga, S., Sofela, A., Dave, F., Negroni, C., Kurian, K. M., Hilton, D. A. & Hanemann, C. O., 13 Feb 2020, In : International Journal of Molecular Sciences. 21, 4

    Research output: Contribution to journalArticle (Academic Journal)

  • DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study

    Pickles, J. C., Fairchild, A. R., Stone, T. J., Brownlee, L., Merve, A., Yasin, S. A., Avery, A., Ahmed, S. W., Ogunbiyi, O., Gonzalez Zapata, J., Peary, A. F., Edwards, M., Wilkhu, L., Dryden, C., Ladon, D., Kristiansen, M., Rowe, C., Kurian, K. M., Nicoll, J. A. R., Mitchell, C. & 29 others, Bloom, T., Hilton, D. A., Al-Sarraj, S., Doey, L., Johns, P. N., Bridges, L. R., Chakrabarty, A., Ismail, A., Rathi, N., Syed, K., Lammie, G. A., Limback-Stanic, C., Smith, C., Torgersen, A., Rae, F., Hill, R. M., Clifford, S. C., Grabovska, Y., Williamson, D., Clarke, M., Jones, C., Capper, D., Sill, M., von Deimling, A., Pfister, S. M., Jones, D. T. W., Hargrave, D., Chalker, J. & Jacques, T. S., 1 Feb 2020, In : The Lancet Child and Adolescent Health. 4, 2, p. 121-130 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 5 Citations (Scopus)
    14 Downloads (Pure)

    EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma

    Struve, N., Binder, Z. A., Stead, L. F., Brend, T., Bagley, S. J., Faulkner, C., Ott, L., Müller-Goebel, J., Weik, A-S., Hoffer, K., Krug, L., Rieckmann, T., Bußmann, L., Henze, M., Morrissette, J. J. D., Kurian, K. M., Schüller, U., Petersen, C., Rothkamm, K., O Rourke, D. M. & 2 others, Short, S. C. & Kriegs, M., 17 Feb 2020, In : Oncogene.

    Research output: Contribution to journalArticle (Academic Journal)