Organization profile

Organisation profile

Cancer research at Bristol is a vibrant cross-disciplinary community. In partnership with Bristol NHS Trusts and the University of West of England (UWE), we aim to accelerate the identification and translation of research into clinical practice for the early detection and treatment of cancer.

Cancer is a leading cause of death and morbidity worldwide, and with the ageing of the population and changes in lifestyle such as increasing obesity, its incidence is likely to continue to rise. Research in Bristol, lead by internationally recognised experts in the field, is looking to enhance early diagnostics, screening and prevention of a variety of cancers.

Cancer research in Bristol focuses on three areas of internationally recognised research strengths: cancer cell biology, genetic and lifecourse epidemiology and health services research and service delivery. Specifically this includes research into:

  • cell signalling and gene deregulation
  • angiogenesis, cell death and the tumour microenvironment
  • cytoskeleton, migration and invasion
  • prostate cancer screening and aetiology (through the ProtecT and ProMPT collaborations)
  • Mendelian randomisation and genetic markers in the progression of cancer
  • methodological development for randomised controlled trials of cancer treatment
  • patient reported outcomes and health related quality of life measurements
  • statistical evaluation of diagnostic techniques
  • intervention and prevention programmes: promotion of health, diet and lifestyle
  • service delivery in secondary care
  • early diagnosis in primary care

Principally, but not exclusively, the therapeutic focus is on cancers of the gastro-intestinal tract (including colon) and prostate.

In Bristol we have unique access to extensive DNA and tissue banks, as well as patient/population data. Together these provide unrivalled opportunities to discover, understand and use novel and existing cancer biomarkers for improving cancer detection, treatment and care.

Fingerprint Dive into the research topics where Cancer is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    ADHD and depression: investigating a causal explanation

    Riglin, L., Leppert, B., Dardani, C., Thapar, A., Rice, F., O'Donovan, M. C., Davey Smith, G., Stergiakouli, E., Tilling, K. M. & Thapar, A., 6 Apr 2020, In : Psychological Medicine. p. 1 - 8 8 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial

    Birtle, A., Johnson, M., Donovan, J. L. & al., E., 5 Mar 2020, In : The Lancet. 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 32 Downloads (Pure)
    Open Access
  • Projects

    Student theses

    An Epigenome-Wide Association Study of Eczema

    Author: Berryman, K., 7 May 2019

    Supervisor: Paternoster, L. (Supervisor), Elliott, H. (Supervisor) & Relton, C. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Appraising the causal relationship between DNA methylation and type 2 diabetes

    Author: Juvinao-Quintero, D., 7 May 2019

    Supervisor: Elliott, H. (Supervisor), Relton, C. (Supervisor) & Sharp, G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Decentralised Algorithms for Area Coverage

    Author: Young, S. J., 24 Mar 2020

    Supervisor: Ganesh, A. (Supervisor) & Hauert, S. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Prizes

    3rd Place Equipment & Facilities EPSRC Photography Competition 2018

    Hunt, Edmund R (Recipient), Jerry H G Wright (Recipient) & Hauert, Sabine (Recipient), 3 Jun 2019

    Prize: Prizes, Medals, Awards and Grants

  • Academy of Medical Sciences

    Golding, Jean (Recipient), 2002

    Prize: Election to learned society

    Cambridge Cognition Prize

    Munafo, Marcus R (Recipient), 2013

    Prize: Prizes, Medals, Awards and Grants

    Activities

    Mendelian randomization: past, present and future

    George Davey Smith (Speaker)

    23 Jan 2020

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    Maurice Bloch Seminar

    George Davey Smith (Invited speaker)

    29 May 2020

    Activity: Participating in or organising an event typesInvited talk

    Some constraints on the scope and potential of personalised medicine

    George Davey Smith (Speaker)

    30 Jan 2020

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course