• BS16 1LE

    United Kingdom

Research Output

2020

Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea

Buckner, N., Kemp, K. C., Scott, H. L., Shi, G., Rivers, C. A., Gialeli, A., Wong, L-F., Cordero Llana, O., Allen, N., Wilkins, A. & Uney, J. B., 24 Jun 2020, In : Brain Pathology. 15 p.

Research output: Contribution to journalArticle (Academic Journal)

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Accelerated long-term forgetting in healthy older adults predicts cognitive decline over one year

Wearn, A. R., Saunders-Jennings, E., Nurdal, V., Hadley, E., Knight, M. J., Newson, M. A., Kauppinen, R. A. & Coulthard, E. J., 15 Sep 2020, (Accepted/In press) In : Alzheimer's Research and Therapy.

Research output: Contribution to journalArticle (Academic Journal)

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In : Acta Neuropathologica. 18 p.

Research output: Contribution to journalArticle (Academic Journal)

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Alemtuzumab-related eosinophilic central nervous system vasculitis

Leach, O. A., Hilton, D. A., Adams, W., Love, S. & Straukiene, A., 21 Feb 2020, In : Multiple Sclerosis Journal. 4 p.

Research output: Contribution to journalArticle (Academic Journal)

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63 Downloads (Pure)

A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 14 Apr 2020, In : Autophagy. 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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26 Downloads (Pure)

A real-time electronic symptom monitoring system for patients after discharge following surgery: a pilot study in cancer-related surgery

Richards, H. S., Blazeby, J. M., Portal, A., Harding, R., Reed, T., Lander, T., Chalmers, K. A., Carter, R., Absolom, K., Singhal, R., Velikova, G. & Avery, K. N. L., 10 Jun 2020, In : BMC Cancer. 20, 17 p., 543 (2020).

Research output: Contribution to journalArticle (Academic Journal)

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Association of combination statin and antihypertensive therapy with reduced Alzheimer’s disease and related dementia risk

Barthold, D., Joyce, G., Diaz Brinton, R., Wharton, W., Kehoe, P. G. & Zissimopoulos, J., 4 Mar 2020, In : PLoS ONE. 15, 3, 15 p., e0229541.

Research output: Contribution to journalArticle (Academic Journal)

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Baseline Results: The Association between Cardiovascular Risk and Preclinical Alzheimer's Disease Pathology (ASCEND) Study

Kumar, V. V., Huang, H., Zhao, L., Verble, D. D., Nutaitis, A., Tharwani, S. D., Brown, A. L., Zetterberg, H., Hu, W., Shin, R., Kehoe, P. G., Quyyumi, A., Nocera, J., Kippels, A. & Wharton, W., 3 Apr 2020, In : Journal of Alzheimer's Disease. 9 p.

Research output: Contribution to journalArticle (Academic Journal)

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BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease

Harris, M., El Hindy, M., Usmari-Moraes, M., Hudd, F., Shafei, M., Dong, M., Hezwani, M., Clark, P., House, M., Forshaw, T., Kehoe, P. & Conway, M. E., 23 Jan 2020, In : Free Radical Biology and Medicine.

Research output: Contribution to journalArticle (Academic Journal)

Brain biopsy before or after treatment with corticosteroids

Rice, C. M., Renowden, S. A., Urankar, K., Love, S. & Scolding, N. J., 28 Apr 2020, In : Neuroradiology. 2 p.

Research output: Contribution to journalLetter (Academic Journal)

Cerebral venous sinus thrombosis associated with COVID-19

Thompson, A., Morgan, C. A. M., Smith, P., Jones, C., Ball, H. A., Coulthard, E. J., Moran, E., Szewczyk-Krolikowski, K. & Rice, C. M., 15 Sep 2020, (Accepted/In press) In : Practical Neurology.

Research output: Contribution to journalLetter (Academic Journal)

Comparison of antihypertensive drug classes for dementia prevention

Walker, V., Davies, N. M., Martin, R. M. & Kehoe, P. G., 6 Jun 2020, (Accepted/In press) In : Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

Corpus callosal haemorrhage and leucoencephalopathy associated with severe COVID-19

Green, C., Morrison, H. D., Smith, P., Golestani, F., Rice, C. M., Coulthard, E. J., Searle, J. & Lyburn, I., 21 Sep 2020, (Accepted/In press) In : Neurology.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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Dual druggable genome siRNA and compound screening approaches identify novel modulators of parkin recruitment to mitochondria

Scott, H. L., Buckner, N., Fernandez-Albert, F., Pedone, E., Postiglione, L., Shi, G., Allen, N., Wong, L-F., Magini, L., Marucci, L., O’Sullivan, G., Cole, S., Powell, J., Maycox, P. & Uney, J. B., 7 Jan 2020, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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Elevated Cerebrospinal Fluid Sodium in Hypertensive Human Subjects with a Family History of Alzheimer’s Disease

Souza, L., Trebak, F., Kumar, V., Satou, R., Kehoe, P. G., Yang, W., Wharton, W. & Feng Earley, Y., 1 Mar 2020, In : Physiological Genomics. 52, 3, p. 133-142 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies

Akyol, S., Yilmaz, A., Joon Oh, K., Ugur, Z., Aydas, B., McGuinness, B., Passmore, P., Kehoe, P. G., Maddens, M., Green, B. D. & Graham, S. F., 15 Sep 2020, In : Brain Research. 1743, 146897.

Research output: Contribution to journalArticle (Academic Journal)

Fast Periodic Visual Stimulation indexes preserved semantic memory in healthy ageing

Milton, A., Rowland, A., Stothart, G., Clatworthy, P., Pennington, C. M. & Kazanina, N., 4 Aug 2020, In : Scientific Reports. 10, 10 p., 13159 (2020).

Research output: Contribution to journalArticle (Academic Journal)

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Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates

Ling, H., Gelpi, E., Davey, K., Jaunmuktane, Z., Mok, K. Y., Jabbari, E., Simone, R., R'Bibo, L., Brandner, S., Ellis, M., Attems, J., Mann, D., Halliday, G. M., Al-Sarraj, S., Hedreen, J., Ironside, J. W., Kovacs, G. G., Kovari, E., Love, S., Vonsattel, J. P. G. & 10 others, Allinson, K. S. J., Hansen, D., Bradshaw, T., Setó-Salvia, N., Wray, S., de Silva, R., Morris, H. R., Warner, T. T., Holton, J. L. & Revesz, T., 16 Jan 2020, In : Acta Neuropathologica. 18 p.

Research output: Contribution to journalArticle (Academic Journal)

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Functional cognitive disorder: dementia's blind spot

Ball, H. A., McWhirter, L., Ballard, C., Bhome, R., Blackburn, D., Edwards, M., Fleming, S., Fox, N., Howard, R., Huntley, J., Isaacs, J., Larner, AJ., Nicholson, T., Pennington, C. M., Poole, N., Price, G., Price, J., Reuber, M., Ritchie, C., Rossor, M. & 5 others, Schott, J., Teodoro, T., Venneri, A., Stone, J. & Carson, A. J., 13 Aug 2020, In : Brain. 9 p., awaa224.

Research output: Contribution to journalReview article (Academic Journal)

Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

Anderson, E. L., Richmond, R., Jones, S. E., Hemani, G., Wade, K. H., Dashti, H. S., Lane, J. M., Wang, H., Saxena, R., Brumpton, B. M., Korologou-Linden, R. S., Nielsen, J. B., Asvold, B. O., Abecasis, G. R., Coulthard, E. J., Kyle, S. D., Beaumont, R. N., Tyrrell, J., Frayling, T., Munafo, M. R. & 6 others, Wood, A. R., Ben-Shlomo, Y., Howe, L. D., Lawlor, D. A., Weedon, M. N. & Davey Smith, G., 28 Jul 2020, (Accepted/In press) In : International Journal of Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

LIR-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Jimenez Moreno, N., Stathakos, P., Anton, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. A. & Lane, J. D., 2020, (Submitted) In : The Journal of cell biology.

Research output: Contribution to journalArticle (Academic Journal)

Mixed neuropathology in frontotemporal lobar degeneration

Pennington, C., Marini, L., Coulthard, E. & Love, S., 2 Mar 2020, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. p. 1-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Downloads (Pure)

Potential human transmission of amyloid beta pathology: surveillance and risks

Lauwers, E., Love, S., de Strooper, B. & al., E., 16 Sep 2020, In : Lancet Neurology. 19, 10, p. 872-878 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Prospective memory in prodromal Alzheimer’s Disease: real world relevance and correlations with cortical thickness and hippocampal subfield volumes

Nurdal, V., Wearn, A., Knight, M., Kauppinen, R. & Coulthard, E., 22 Feb 2020, In : NeuroImage: Clinical. 26, 10 p., 102226.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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Reporting of key methodological issues in placebo-controlled trials of surgery needs improvement: a systematic review

Cousins, S., Blencowe, N. S., Tsang, C., Lorenc, A., Chalmers, K., Carr, A. J., Campbell, M. K., Cook, J. A., Beard, D. J. & Blazeby, J. M., 1 Mar 2020, In : Journal of Clinical Epidemiology. 119, p. 109-116 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
76 Downloads (Pure)

Short-term memory advantage for brief durations in human APOE ε4 carriers

Zokaei, N., Grogan, J., Fallon, S. J., Slavkova, E., Hadida, J., Manohar, S., Nobre, A. C. & Husain, M., 11 Jun 2020, In : Scientific Reports. 10, 1, p. 9503

Research output: Contribution to journalArticle (Academic Journal)

Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury

Prager, J., Adams, C. F., Delaney, A. M., Chanoit, G., Tarlton, J. F., Wong, L-F., Chari, D. M. & Granger, N., 17 Jul 2020, In : Journal of Tissue Engineering. 11, p. 2041731420934806

Research output: Contribution to journalArticle (Academic Journal)

T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Wearn, A. R., Nurdal, V., Saunders-Jennings, E., Knight, M. J., Isotalus, H. K., Dillon, S., Tsivos, D., Kauppinen, R. A. & Coulthard, E. J., 10 Sep 2020, In : Alzheimer's Research and Therapy. 12, 14 p., 105 (2020) .

Research output: Contribution to journalArticle (Academic Journal)

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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J. H., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C. & 18 others, Macleod, M., McColl, B. W., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E. S., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M. & Quinn, T. J., 9 Mar 2020, In : Journal of Cerebral Blood Flow and Metabolism. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

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50 Downloads (Pure)
2019

An investigation of antihypertensive class, dementia and cognitive decline. A meta-analysis.

Peters, R., Yasar, S., Anderson, C., Andrews, S., Antikainen, R., Beckett, N., Beer, J. C., Bertens, A. S., Booth, A., van Boxtel, M., Brayne, C. E. G., Brodaty, H., Carlson, M. C., Chalmers, J., Corrada, M., DeKosky, S., Derby, C., Dixon, R. A., Forette, F., Ganguli, M. & 38 others, van Gool, W. A., Guaita, A., Hever, A., Hogan, D. B., Jagger, C., Katz, M., Kawas, C., Kehoe, P., Keinanen-Kiukaanniemi, S. M., Kenny, R. A., Köhler, S., Kunutsor, S., Laukkanen, J., Maxwell, C., McFall, G. P., van Middelaar, T., van Charante, E. P. M., Tze-Pin, N., Peters, J., Rawtaer, I., Richard, E., Rockwood, K., Rydén, L., Sachdev, P. S., Skoog, I., Skoog, J., Staessen, J. A., Stephan, B. CM., Sebert, S. P., Thijs, L., Trompet, S., Tully, P. J., Tzourio, C., Vaccaro, R., Varamo, E., Walsh, E., Warwick, J. & Anstey, K. J., 11 Dec 2019, In : Neurology. 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease

Grimmer, T., Goldhardt, O., Yakushev, I., Ortner, M., Sorg, C., Diehl-Schmid, J., Förstl, H., Kurz, A., Perneczky, R. & Miners, S., 1 Aug 2019, In : Neurodegenerative Diseases. 19, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Cerebrospinal fluid changes in the renin-angiotensin system in Alzheimer's disease

Kehoe, P. G., Al Mulhim, N. S. K., Zetterberg, H., Blennow, K. & Miners, J. S., 12 Nov 2019, In : Journal of Alzheimer's Disease. 72, 2, p. 525-535 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
74 Downloads (Pure)
Open Access
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149 Downloads (Pure)

CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology

Miners, J. S., Kehoe, P. G., Love, S., Zetterberg, H. & Blennow, K., 14 Sep 2019, In : Alzheimer's Research and Therapy. 11, 6 p., 81.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
119 Downloads (Pure)

Dear Reader: Data Citation in Changing Times

Glatzel, M. & Love, S., 1 Mar 2019, In : Brain Pathology. 29, 2, p. 153-154 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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Diagnostic accuracy of frontotemporal dementia. An artificial intelligence-powered study of symptoms, imaging and clinical judgement

Brzezicki, M. A., Kobetić, M. D., Neumann, S. & Pennington, C., 1 Sep 2019, In : Advances in Medical Sciences. 64, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
61 Downloads (Pure)
Open Access
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1 Citation (Scopus)
169 Downloads (Pure)

Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)

Femminella, G. D., Frangou, E., Love, S. B., Busza, G., Holmes, C., Ritchie, C., Lawrence, R., McFarlane, B., Tadros, G., Ridha, B. H., Bannister, C., Walker, Z., Archer, H., Coulthard, E., Underwood, B. R., Prasanna, A., Koranteng, P., Karim, S., Junaid, K., McGuinness, B. & 14 others, Nilforooshan, R., Macharouthu, A., Donaldson, A., Thacker, S., Russell, G., Malik, N., Mate, V., Knight, L., Kshemendran, S., Harrison, J., Brooks, D. J., Passmore, A. P., Ballard, C. & Edison, P., 3 Apr 2019, In : Trials. 20, 10 p., 191.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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Evaluating the effects of the novel GLP-1 analogue liraglutide in patients with Alzheimer's disease (ELAD Study)

Femminella, G. D., Frangou, E., Love, S., Busza, G., Holmes, C., Ritchie, C., Lawrence, R., McFarlane, B., Tadros, G., Ridha, B., Bannister, C., Archer, H., Coulthard, L., Underwood, B., Prasanna, A., Koranteng, P., Karim, S., Junaid, K., McGuinness, B., Nilforooshan, R. & 13 others, Macharouthu, A., Donaldson, A., Thacker, S., Russell, G., Malik, N., Mate, V., Knight, L., Kshemendran, S., Harrison, J., Brooks, D., Passmore, A. P., Ballard, C. & Edison, P., 15 Mar 2019, (Accepted/In press) In : Trials.

Research output: Contribution to journalArticle (Academic Journal)

Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus

Spaull, R., McPherson, B., Gialeli, A., Clayton, A., Uney, J., Heep, A. & Cordero-Llana, Ó., Apr 2019, In : International Journal of Developmental Neuroscience. 73, p. 59-65 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
82 Downloads (Pure)

Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy

Kiely, A. P., Miners, S., Courteny, R., Strand, CV., Love, S. & Holton, J. L., 1 Jun 2019, In : Neuropathology and Applied Neurobiology. 45, 4, p. 347-360 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
106 Downloads (Pure)

Functional cognitive disorder: Diagnostic challenges and future directions

Pennington, C., Ball, H. & Swirski, M., 28 Sep 2019, In : Diagnostics. 9, 4, 8 p., 131.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
79 Downloads (Pure)

Functional Cognitive Disorder

Pennington, C. & Coulthard, L., 5 Mar 2019, (Accepted/In press) Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier Science

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), 28 Feb 2019, In : Nature Genetics. 51, 3, p. 414-430 22 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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209 Citations (Scopus)
179 Downloads (Pure)

Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses

Rivers, C. A., Rogers, M. F., Stubbs, F. E., Conway-Campbell, B. L., Lightman, S. L. & Pooley, J. R., 1 May 2019, In : Endocrinology. 160, 5, p. 1044-1056 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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8 Citations (Scopus)
180 Downloads (Pure)

Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research

Stathakos, P., Jimenez Moreno, N., Crompton, L., Nistor, P., Caldwell, M. & Lane, J., 5 Jan 2019, Autophagy. Humana Press, p. 257-280 23 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
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1 Citation (Scopus)
76 Downloads (Pure)

Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer: A prospective study in patients with non-small cell lung cancer

Avery, K. N. L., Blazeby, J. M., Chalmers, K. A., Batchelor, T. J. P., Casali, G., Internullo, E., Krishnadas, R., Evans, C. & West, D., 1 Dec 2019, In : Annals of Surgical Oncology. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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