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Article (Academic Journal)
2020

Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea

Buckner, N., Kemp, K. C., Scott, H. L., Shi, G., Rivers, C. A., Gialeli, A., Wong, L-F., Cordero Llana, O., Allen, N., Wilkins, A. & Uney, J. B., 24 Jun 2020, In : Brain Pathology. 15 p.

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ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In : Acta Neuropathologica. 18 p.

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Alemtuzumab-related eosinophilic central nervous system vasculitis

Leach, O. A., Hilton, D. A., Adams, W., Love, S. & Straukiene, A., 21 Feb 2020, In : Multiple Sclerosis Journal. 4 p.

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A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 14 Apr 2020, In : Autophagy. 17 p.

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A real-time electronic symptom monitoring system for patients after discharge following surgery: a pilot study in cancer-related surgery

Richards, H. S., Blazeby, J. M., Portal, A., Harding, R., Reed, T., Lander, T., Chalmers, K. A., Carter, R., Absolom, K., Singhal, R., Velikova, G. & Avery, K. N. L., 10 Jun 2020, In : BMC Cancer. 20, 17 p., 543 (2020).

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Association of combination statin and antihypertensive therapy with reduced Alzheimer’s disease and related dementia risk

Barthold, D., Joyce, G., Diaz Brinton, R., Wharton, W., Kehoe, P. G. & Zissimopoulos, J., 4 Mar 2020, In : PLoS ONE. 15, 3, 15 p., e0229541.

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Baseline Results: The Association between Cardiovascular Risk and Preclinical Alzheimer's Disease Pathology (ASCEND) Study

Kumar, V. V., Huang, H., Zhao, L., Verble, D. D., Nutaitis, A., Tharwani, S. D., Brown, A. L., Zetterberg, H., Hu, W., Shin, R., Kehoe, P. G., Quyyumi, A., Nocera, J., Kippels, A. & Wharton, W., 3 Apr 2020, In : Journal of Alzheimer's Disease. 9 p.

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BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease

Harris, M., El Hindy, M., Usmari-Moraes, M., Hudd, F., Shafei, M., Dong, M., Hezwani, M., Clark, P., House, M., Forshaw, T., Kehoe, P. & Conway, M. E., 23 Jan 2020, In : Free Radical Biology and Medicine.

Research output: Contribution to journalArticle (Academic Journal)

Comparison of antihypertensive drug classes for dementia prevention

Walker, V., Davies, N. M., Martin, R. M. & Kehoe, P. G., 6 Jun 2020, (Accepted/In press) In : Epidemiology.

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Dual druggable genome siRNA and compound screening approaches identify novel modulators of parkin recruitment to mitochondria

Scott, H. L., Buckner, N., Fernandez-Albert, F., Pedone, E., Postiglione, L., Shi, G., Allen, N., Wong, L-F., Magini, L., Marucci, L., O’Sullivan, G., Cole, S., Powell, J., Maycox, P. & Uney, J. B., 7 Jan 2020, In : Journal of Biological Chemistry.

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Elevated Cerebrospinal Fluid Sodium in Hypertensive Human Subjects with a Family History of Alzheimer’s Disease

Souza, L., Trebak, F., Kumar, V., Satou, R., Kehoe, P. G., Yang, W., Wharton, W. & Feng Earley, Y., 1 Mar 2020, In : Physiological Genomics. 52, 3, p. 133-142 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies

Akyol, S., Yilmaz, A., Joon Oh, K., Ugur, Z., Aydas, B., McGuinness, B., Passmore, P., Kehoe, P. G., Maddens, M., Green, B. D. & Graham, S. F., 15 Sep 2020, In : Brain Research. 1743, 146897.

Research output: Contribution to journalArticle (Academic Journal)

Fast Periodic Visual Stimulation indexes preserved semantic memory in healthy ageing

Milton, A., Rowland, A., Stothart, G., Clatworthy, P., Pennington, C. M. & Kazanina, N., 4 Aug 2020, In : Scientific Reports. 10, 10 p., 13159 (2020).

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Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates

Ling, H., Gelpi, E., Davey, K., Jaunmuktane, Z., Mok, K. Y., Jabbari, E., Simone, R., R'Bibo, L., Brandner, S., Ellis, M., Attems, J., Mann, D., Halliday, G. M., Al-Sarraj, S., Hedreen, J., Ironside, J. W., Kovacs, G. G., Kovari, E., Love, S., Vonsattel, J. P. G. & 10 others, Allinson, K. S. J., Hansen, D., Bradshaw, T., Setó-Salvia, N., Wray, S., de Silva, R., Morris, H. R., Warner, T. T., Holton, J. L. & Revesz, T., 16 Jan 2020, In : Acta Neuropathologica. 18 p.

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Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

Anderson, E. L., Richmond, R., Jones, S. E., Hemani, G., Wade, K. H., Dashti, H. S., Lane, J. M., Wang, H., Saxena, R., Brumpton, B. M., Korologou-Linden, R. S., Nielsen, J. B., Asvold, B. O., Abecasis, G. R., Coulthard, E. J., Kyle, S. D., Beaumont, R. N., Tyrrell, J., Frayling, T., Munafo, M. R. & 6 others, Wood, A. R., Ben-Shlomo, Y., Howe, L. D., Lawlor, D. A., Weedon, M. N. & Davey Smith, G., 28 Jul 2020, (Accepted/In press) In : International Journal of Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

LIR-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Jimenez Moreno, N., Stathakos, P., Anton, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. A. & Lane, J. D., 2020, (Submitted) In : The Journal of cell biology.

Research output: Contribution to journalArticle (Academic Journal)

Mixed neuropathology in frontotemporal lobar degeneration

Pennington, C., Marini, L., Coulthard, E. & Love, S., 2 Mar 2020, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. p. 1-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Downloads (Pure)

Prospective memory in prodromal Alzheimer’s Disease: real world relevance and correlations with cortical thickness and hippocampal subfield volumes

Nurdal, V., Wearn, A., Knight, M., Kauppinen, R. & Coulthard, E., 22 Feb 2020, In : NeuroImage: Clinical. 26, 10 p., 102226.

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Reporting of key methodological issues in placebo-controlled trials of surgery needs improvement: a systematic review

Cousins, S., Blencowe, N. S., Tsang, C., Lorenc, A., Chalmers, K., Carr, A. J., Campbell, M. K., Cook, J. A., Beard, D. J. & Blazeby, J. M., 1 Mar 2020, In : Journal of Clinical Epidemiology. 119, p. 109-116 8 p.

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2 Citations (Scopus)
76 Downloads (Pure)

Short-term memory advantage for brief durations in human APOE ε4 carriers

Zokaei, N., Grogan, J., Fallon, S. J., Slavkova, E., Hadida, J., Manohar, S., Nobre, A. C. & Husain, M., 11 Jun 2020, In : Scientific Reports. 10, 1, p. 9503

Research output: Contribution to journalArticle (Academic Journal)

Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury

Prager, J., Adams, C. F., Delaney, A. M., Chanoit, G., Tarlton, J. F., Wong, L-F., Chari, D. M. & Granger, N., 17 Jul 2020, In : Journal of Tissue Engineering. 11, p. 2041731420934806

Research output: Contribution to journalArticle (Academic Journal)

T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Wearn, A. R., Nurdal, V., Saunders-Jennings, E., Knight, M. J., Isotalus, H. K., Dillon, S., Tsivos, D., Kauppinen, R. A. & Coulthard, E. J., 10 Sep 2020, In : Alzheimer's Research and Therapy. 12, 14 p., 105 (2020) .

Research output: Contribution to journalArticle (Academic Journal)

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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J. H., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C. & 18 others, Macleod, M., McColl, B. W., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E. S., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M. & Quinn, T. J., 9 Mar 2020, In : Journal of Cerebral Blood Flow and Metabolism. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

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2019

An investigation of antihypertensive class, dementia and cognitive decline. A meta-analysis.

Peters, R., Yasar, S., Anderson, C., Andrews, S., Antikainen, R., Beckett, N., Beer, J. C., Bertens, A. S., Booth, A., van Boxtel, M., Brayne, C. E. G., Brodaty, H., Carlson, M. C., Chalmers, J., Corrada, M., DeKosky, S., Derby, C., Dixon, R. A., Forette, F., Ganguli, M. & 38 others, van Gool, W. A., Guaita, A., Hever, A., Hogan, D. B., Jagger, C., Katz, M., Kawas, C., Kehoe, P., Keinanen-Kiukaanniemi, S. M., Kenny, R. A., Köhler, S., Kunutsor, S., Laukkanen, J., Maxwell, C., McFall, G. P., van Middelaar, T., van Charante, E. P. M., Tze-Pin, N., Peters, J., Rawtaer, I., Richard, E., Rockwood, K., Rydén, L., Sachdev, P. S., Skoog, I., Skoog, J., Staessen, J. A., Stephan, B. CM., Sebert, S. P., Thijs, L., Trompet, S., Tully, P. J., Tzourio, C., Vaccaro, R., Varamo, E., Walsh, E., Warwick, J. & Anstey, K. J., 11 Dec 2019, In : Neurology. 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease

Grimmer, T., Goldhardt, O., Yakushev, I., Ortner, M., Sorg, C., Diehl-Schmid, J., Förstl, H., Kurz, A., Perneczky, R. & Miners, S., 1 Aug 2019, In : Neurodegenerative Diseases. 19, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Cerebrospinal fluid changes in the renin-angiotensin system in Alzheimer's disease

Kehoe, P. G., Al Mulhim, N. S. K., Zetterberg, H., Blennow, K. & Miners, J. S., 12 Nov 2019, In : Journal of Alzheimer's Disease. 72, 2, p. 525-535 11 p.

Research output: Contribution to journalArticle (Academic Journal)

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1 Citation (Scopus)
70 Downloads (Pure)
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CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology

Miners, J. S., Kehoe, P. G., Love, S., Zetterberg, H. & Blennow, K., 14 Sep 2019, In : Alzheimer's Research and Therapy. 11, 6 p., 81.

Research output: Contribution to journalArticle (Academic Journal)

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7 Citations (Scopus)
118 Downloads (Pure)

Dear Reader: Data Citation in Changing Times

Glatzel, M. & Love, S., 1 Mar 2019, In : Brain Pathology. 29, 2, p. 153-154 2 p.

Research output: Contribution to journalArticle (Academic Journal)

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Diagnostic accuracy of frontotemporal dementia. An artificial intelligence-powered study of symptoms, imaging and clinical judgement

Brzezicki, M. A., Kobetić, M. D., Neumann, S. & Pennington, C., 1 Sep 2019, In : Advances in Medical Sciences. 64, 2, p. 292-302 11 p.

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2 Citations (Scopus)
61 Downloads (Pure)

Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)

Femminella, G. D., Frangou, E., Love, S. B., Busza, G., Holmes, C., Ritchie, C., Lawrence, R., McFarlane, B., Tadros, G., Ridha, B. H., Bannister, C., Walker, Z., Archer, H., Coulthard, E., Underwood, B. R., Prasanna, A., Koranteng, P., Karim, S., Junaid, K., McGuinness, B. & 14 others, Nilforooshan, R., Macharouthu, A., Donaldson, A., Thacker, S., Russell, G., Malik, N., Mate, V., Knight, L., Kshemendran, S., Harrison, J., Brooks, D. J., Passmore, A. P., Ballard, C. & Edison, P., 3 Apr 2019, In : Trials. 20, 10 p., 191.

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Evaluating the effects of the novel GLP-1 analogue liraglutide in patients with Alzheimer's disease (ELAD Study)

Femminella, G. D., Frangou, E., Love, S., Busza, G., Holmes, C., Ritchie, C., Lawrence, R., McFarlane, B., Tadros, G., Ridha, B., Bannister, C., Archer, H., Coulthard, L., Underwood, B., Prasanna, A., Koranteng, P., Karim, S., Junaid, K., McGuinness, B., Nilforooshan, R. & 13 others, Macharouthu, A., Donaldson, A., Thacker, S., Russell, G., Malik, N., Mate, V., Knight, L., Kshemendran, S., Harrison, J., Brooks, D., Passmore, A. P., Ballard, C. & Edison, P., 15 Mar 2019, (Accepted/In press) In : Trials.

Research output: Contribution to journalArticle (Academic Journal)

Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus

Spaull, R., McPherson, B., Gialeli, A., Clayton, A., Uney, J., Heep, A. & Cordero-Llana, Ó., Apr 2019, In : International Journal of Developmental Neuroscience. 73, p. 59-65 7 p.

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4 Citations (Scopus)
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Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy

Kiely, A. P., Miners, S., Courteny, R., Strand, CV., Love, S. & Holton, J. L., 1 Jun 2019, In : Neuropathology and Applied Neurobiology. 45, 4, p. 347-360 14 p.

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3 Citations (Scopus)
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Functional cognitive disorder: Diagnostic challenges and future directions

Pennington, C., Ball, H. & Swirski, M., 28 Sep 2019, In : Diagnostics. 9, 4, 8 p., 131.

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2 Citations (Scopus)
77 Downloads (Pure)

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), 28 Feb 2019, In : Nature Genetics. 51, 3, p. 414-430 22 p.

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205 Citations (Scopus)
179 Downloads (Pure)

Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses

Rivers, C. A., Rogers, M. F., Stubbs, F. E., Conway-Campbell, B. L., Lightman, S. L. & Pooley, J. R., 1 May 2019, In : Endocrinology. 160, 5, p. 1044-1056 13 p.

Research output: Contribution to journalArticle (Academic Journal)

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8 Citations (Scopus)
180 Downloads (Pure)

Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer: A prospective study in patients with non-small cell lung cancer

Avery, K. N. L., Blazeby, J. M., Chalmers, K. A., Batchelor, T. J. P., Casali, G., Internullo, E., Krishnadas, R., Evans, C. & West, D., 1 Dec 2019, In : Annals of Surgical Oncology. 13 p.

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KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences

Hares, K. M., Miners, S., Scolding, N., Love, S. & Wilkins, A., 19 Feb 2019, In : AMRC Open Research. 1, 22 p., 1.

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Levodopa does not affect expression of reinforcement learning in older adults

Grogan, J. P., Isotalus, H. K., Howat, A., Irigoras Izagirre, N., Knight, L. E. & Coulthard, E. J., 23 Apr 2019, In : Scientific Reports. 9, 1, p. 6349 10 p., 6349.

Research output: Contribution to journalArticle (Academic Journal)

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1 Citation (Scopus)
207 Downloads (Pure)

Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs

Ito, D., Carwardine, D., Prager, J., Wong, L. F., Kitagawa, M., Jeffery, N. & Granger, N., 6 Mar 2019, In : PLoS ONE. 14, 3, 20 p., e0213252.

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Myelin breakdown in human Huntington's disease: Multi-modal evidence from diffusion MRI and quantitative magnetization transfer

Bourbon-Teles, J., Bells, S., Jones, D. K., Coulthard, E., Rosser, A. & Metzler-Baddeley, C., 1 Apr 2019, In : Neuroscience. 403, p. 79-92

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Nap‐mediated benefit to implicit information processing across age using an affective priming paradigm

Shaikh, N. & Coulthard, L., 1 Feb 2019, In : Journal of Sleep Research. 28, 1, 7 p., e12728.

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Network substrates of cognitive impairment in Alzheimer's Disease

Tait, L., Stothart, G., Coulthard, E., Brown, J. T., Kazanina, N. & Goodfellow, M., 1 Sep 2019, In : Clinical Neurophysiology. 130, 9, p. 1581-1595 15 p.

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4 Citations (Scopus)
170 Downloads (Pure)

Neural correlates of altered insight in frontotemporal dementia: a systematic review

Muñoz-Neira, C., Tedde, A., Coulthard, E. J., Thai, N. J. & Pennington, C. M., 5 Nov 2019, In : NeuroImage: Clinical. 24, 16 p., 102066.

Research output: Contribution to journalArticle (Academic Journal)

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Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry– potential for early diagnosis of Alzheimer’s disease

Hudd, F., Shiel, A., Harris, M., Bowdler, P., Wood, B., Tsivos, D., Wearn, A., Knight, M., Kauppinen, R., Coulthard, L., White, P. & Conway, M., 12 Feb 2019, In : Journal of Alzheimer's Disease. 67, 3, p. 931-947 17 p.

Research output: Contribution to journalArticle (Academic Journal)

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6 Citations (Scopus)
278 Downloads (Pure)

Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer’s disease

Nicoll, J. A. R., Buckland, G. R., Harrison, C. H., Page, A., Harris, S., Love, S., Neal, J. W., Holmes, C. & Boche, D., 3 Jun 2019, In : Brain. 142, 7, p. 2113–2126 14 p.

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25 Citations (Scopus)
201 Downloads (Pure)