Organization profile

Organisation profile

Head of Research Group : Professor Andres Lopez Bernal

My research concerns the adaptation of the human uterus to pregnancy and the prevention of prematurity. Preterm labour is the major cause of perinatal mortality and neurological disability in the surviving infants, but it is difficult to predict and manage. Current medication for preterm labour is inefficient or has serious maternal or fetal side effects.

I have focused on the study of the neurohypophyseal hormone oxytocin and inflammatory lipid mediators including prostaglandins in the control of uterine activity. Moreover, in order to predict preterm labour and identify women at risk, I am studying potential biomarkers among proteins, peptides and other molecules released from the feto-placental unit into the maternal circulation.

We have established novel functional methods in uterine smooth muscle (myometrium) combining contractility measurements with identification of specific phosphorylated residues in key contractile proteins. My research will lead to better understanding of the mechanism of parturition in women, and provide new approaches for pharmacological intervention in preterm labour and better methods for induction and augmentation of labour.

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  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    • 34 Article (Academic Journal)
    • 1 Chapter in a book
    Open Access
    File
  • 160 Downloads (Pure)

    Dual role of CREB in the regulation of VSMC proliferation: mode of activation determines pro- or anti-mitogenic function

    Hudson, C., Kimura, T. E., Duggirala, A., Sala-Newby, G. B., Newby, A. C. & Bond, M., 20 Mar 2018, In : Scientific Reports. 8, 15 p., 4904.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 8 Citations (Scopus)
    231 Downloads (Pure)

    Smoking alters hydroxyprostaglandin dehydrogenase expression in fetal membranes

    Ion, R., Hudson, C., Johnson, J., Yuan, W., Heesom, K. & López Bernal, A., 1 Dec 2018, In : Reproductive Toxicology. 82, p. 18-24 7 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 120 Downloads (Pure)

    Projects

    Novel mechanisms of oxytocin function in human myometrial cells

    López Bernal, A., Hudson, C. A. & Kirby, A. M.

    1/01/121/01/16

    Project: Research

    Prizes

    Rogerio A. Lobo Award

    Andrés López Bernal (Recipient), 20 Mar 2018

    Prize: Prizes, Medals, Awards and Grants

  • Activities

    • 1 Editorial activity
    • 1 Advisory work for/on national or international committee or working group
    • 1 Membership or peer review panel or committee

    Royal College of Obstetricians and Gynaecologists (External organisation)

    Andrés López Bernal (Member)

    1 Jan 20141 Jan 2017

    Activity: Membership typesMembership or peer review panel or committee

    Royal College of Obstetricians and Gynaecologists (External organisation)

    Andrés López Bernal (Contributor)

    1 Jan 20131 Jan 2017

    Activity: Membership typesAdvisory work for/on national or international committee or working group

    Reproductive Sciences (Journal)

    Andrés López Bernal (Editor)

    3 Jan 20133 Jan 2017

    Activity: Publication peer-review and editorial work typesEditorial activity