EPSRC Centre for Doctoral Training in Chemical Synthesis

  • Cantock's Close, Synthetic Chemistry Building (SCB)

    BS8 1TS Bristol

    United Kingdom

Research Output

  • 222 Article (Academic Journal)
  • 5 Chapter in a book
  • 2 Review article (Academic Journal)
  • 1 Special issue (Academic Journal)
2020

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In : Acta Neuropathologica. 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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65 Downloads (Pure)

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, In : ACS Chemical Biology. 2020, 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates

Doobary, S., Sedikides, A. T., Caldora, H. P., Poole, D. L. & Lennox, A. J. J., 13 Jan 2020, In : Angewandte Chemie - International Edition. 59, 3, p. 1155-1160 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
109 Downloads (Pure)

Mapping the multi-step mechanism of a photoredox catalyzed atom-transfer radical polymerization reaction by direct observation of the reactive intermediates

Lewis-Borrell, L., Sneha, M., Bhattacherjee, A., Clark, I. P. & Orr-Ewing, A. J., 16 Apr 2020, In : Chemical Science. 11, p. 4475-4481 7 p., 4475.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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38 Downloads (Pure)

Minimal manual input

Heard, D. M. & Lennox, A. J. J., 3 Feb 2020, In : Nature Chemistry. 12, 2, p. 113-114 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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23 Downloads (Pure)

Odd–even alternations in helical propensity of a homologous series of hydrocarbons

Pradeilles, J. A., Zhong, S., Baglyas, M., Tarczay, G., Butts, C. P., Myers, E. L. & Aggarwal, V. K., 2 Mar 2020, In : Nature Chemistry. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Downloads (Pure)

Photosynthesis and crop productivity are enhanced by glucose-functionalized carbon dots

Swift, T., Fagan, D., Benito-Alifonso, D., Hill, S. A., Yallop, M. L., Lawson, T., Oliver, T. A. A., Galan, M. C. & Whitney, H. M., 19 Aug 2020, In : New Phytologist.

Research output: Contribution to journalArticle (Academic Journal)

Open Access

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

Henderson, A. S., Bower, J. F. & Galan, M. C., 29 Apr 2020, In : Organic and Biomolecular Chemistry. 18, 16, p. 3012-3016 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Selective glucose sensing in complex media using a biomimetic receptor

Tromans, R. A., Samanta, S. K., Chapman, A. M. & Davis, A. P., 25 Feb 2020, In : Chemical Science. p. 3223-3227

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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18 Downloads (Pure)

Solvent-dependent photochemical dynamics of a phenoxazine-based photoredox catalyst

Sneha, M., Lewis-Borrell, L., Shchepanovska, D., Bhattacherjee, A., Tyler, J. L. & Orr-Ewing, A. J., 27 Aug 2020, In : Zeitschrift für Physikalische Chemie. 234, p. 1475 - 1494

Research output: Contribution to journalArticle (Academic Journal)

Stiff‐Stilbene Ligands Target G‐Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity

Galan, M. C., O'Hagan, M. P., Morales, J. C., Fisher, R. & Peñalver, P., 28 Feb 2020, (Accepted/In press) In : Chemistry - A European Journal.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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61 Downloads (Pure)

Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation

Nair, A. V., Robson, A., Ackrill, T. D., Till, M., Byrne, M. J., Back, C., Tiwari, K., Davies, J., Willis, C. L. & Race, P. R., 30 Jul 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journalArticle (Academic Journal)

Total Synthesis of Kalimantacin A

Davies, J. A., Bull, F. M., Walker, P. D., Weir, A. N. M., Lavigne, R., Masschelein, J., Simpson, T. J., Race, P. R., Crump, M. P. & Willis, C. L., 21 Aug 2020, In : Organic Letters. 22, 16, p. 6349-6353 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

O'Hagan, M. P., Ramos-Soriano, J., Haldar, S., Sheikh, S., Morales, J. C., Mulholland, A. J. & Galan, M. C., 11 May 2020, In : Chemical Communications. 56, 38, p. 5186-5189 4 p.

Research output: Contribution to journalArticle (Academic Journal)

2019

A biomimetic receptor for glucose

Tromans, R. A., Carter, T. S., Chabanne, L., Crump, M. P., Li, H., Matlock, J. V., Orchard, M. G. & Davis, A. P., Jan 2019, In : Nature Chemistry. 11, 1, p. 52-56 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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48 Citations (Scopus)
305 Downloads (Pure)

A Natural Diels-Alder Biocatalyst Enables Efficient [4 + 2] Cycloaddition Under Harsh Reaction Conditions

Marsh, C. O., Lees, N. R., Han, L-C., Byrne, M. J., Mbatha, S. Z., Maschio, L., Pagden-Ratcliffe, S., Duke, P., Stach, J. E. M., Curnow, P., Willis, C. L. & Race, P. R., 25 Aug 2019, In : ChemCatChem. 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
36 Downloads (Pure)

An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis

Lees, N. R., Han, L-C., Byrne, M., Davies, J., Parnell, A., Moreland, P., Stach, J. E. M., Van der Kamp, M., Willis, C. & Race, P., 18 Feb 2019, In : Angewandte Chemie - International Edition. 58, 8, p. 2305-2309 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
78 Downloads (Pure)

Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

Li, H., Valkenier, H., Thorne, A., Dias, C. M., Cooper, J. A., Keiffer, M., Busschaert, N., Gale, P. A., Sheppard, D. N. & Davis, A. P., 2 Oct 2019, In : Chemical Science. 42, p. 9663-9672 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
143 Downloads (Pure)

A Photoresponsive Stiff-Stilbene Ligand Fuels the Reversible Unfolding of G-Quadruplex DNA

O'Hagan, M., Haldar, S., Duchi, M., Oliver, T. A. A., Mulholland, A., Morales, J. C. & Galan, C., 22 Mar 2019, In : Angewandte Chemie - International Edition. 58, 13, p. 4334-4338 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
47 Downloads (Pure)

A Rapid Synthetic Approach to the ABCD Core of the Stemona Alkaloids

Connelly, R., Knowles, J. & Booker-Milburn, K., 4 Jan 2019, In : Organic Letters. 21, 1, p. 18-21 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
83 Downloads (Pure)

Binding and beyond: what else can G-quadruplex ligands do?

O'Hagan, M., Morales, J. & Galan, C., 5 Jul 2019, In : European Journal of Organic Chemistry. 24 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
25 Downloads (Pure)

Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium‐Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

Dalling, A., Yamauchi, T., McCreanor, N., Cox, L. & Bower, J., 2 Jan 2019, In : Angewandte Chemie - International Edition. 58, 1, p. 221-225 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
122 Downloads (Pure)

Computational mapping of redox-switchable metal complexes based on ferrocene derivatives

Lai, A., Clifton, J., Diaconescu, P. L. & Fey, N., 21 Jun 2019, In : Chemical Communications. 55, 49, p. 7021-7024 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
21 Downloads (Pure)

Control of beta-Branching in Kalimantacin Biosynthesis: Application of 13C NMR to Polyketide Programming

Walker, P., Williams, C., Weir, A., Wang, L., Crosby, J., Race, P., Simpson, T., Willis, C. & Crump, M., 2 Sep 2019, In : Angewandte Chemie. 131, 36, p. 12576-12580 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Downloads (Pure)

Exploring ultraviolet photoinduced charge-transfer dynamics in a model dinucleotide of guanine and thymine

Duchi, M., O'Hagan, M., Kumar, R., Bennie, S., Galan, C., Curchod, B. & Oliver, T. A. A., 3 Jul 2019, In : Physical Chemistry Chemical Physics. 21, 26, p. 14407-14417 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
115 Downloads (Pure)

Facile Synthesis of Chitosan-Based Hydrogels and Microgels through Thiol-Ene Photoclick Crosslinking

Michel, S., Dutertre, F., Denbow, M., Galan, C. & Briscoe, W., 16 Jul 2019, In : ACS Applied Bio Materials. 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
31 Downloads (Pure)

Improving the accuracy of 1H–19F internuclear distance measurement using 2D 1H–19F HOESY

Dewis, L., Crouch, R., Russell, D. & Butts, C., 1 Dec 2019, In : Magnetic Resonance in Chemistry. 57, 12, p. 1143-1149 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
35 Downloads (Pure)

Linear and Branched Fiber-like Micelles from the Crystallization-Driven Self-Assembly of Heterobimetallic Block Copolymer Polyelectrolyte/Surfactant Complexes

Jarrett-Wilkins, C. N., Musgrave, R. A., Hailes, R. L. N., Harniman, R. L., Faul, C. F. J. & Manners, I., 19 Sep 2019, In : Macromolecules. 52, 19, p. 7289-7300 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
10 Downloads (Pure)

Low Length Dispersity Fiber-Like Micelles from an A-B-A Triblock Copolymer with Terminal Crystallizable Poly(ferrocenyldimethylsilane) Segments via Living Crystallization-Driven Self-Assembly

Zhang, Q., He, H., Oliver, A., Pearce, S., Harniman, R., Whittell, G., Liu, Y., Du, S., Leng, J. & Manners, I., 7 Aug 2019, In : Polymer Chemistry. 10, 29, p. 3973-3982 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
30 Downloads (Pure)

Navigating the Structural Landscape of De Novo α-Helical Bundles

Rhys, G. G., Wood, C. W., Beesley, J. L., Zaccai, N. R., Burton, A. J., Brady, R. L., Thomson, A. R. & Woolfson, D. N., 5 Jun 2019, In : Journal of the American Chemical Society. 141, 22, p. 8787-8797 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
43 Downloads (Pure)

Phosphophosphidites Derived from BINOL

Gorman, A., Cross, J., Doyle, R., Leonard, T., Pringle, P. & Sparkes, H., 31 Mar 2019, In : European Journal of Inorganic Chemistry. 2019, 11, p. 1633-1639 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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60 Downloads (Pure)

Picosecond to millisecond tracking of a photocatalytic decarboxylation reaction provides direct mechanistic insights

Bhattacherjee, A., Sneha, M., Lewis-Borrell, L., Tau, O., Clark, I. P. & Orr-Ewing, A. J., 13 Nov 2019, In : Nature Communications. 10, 7 p., 5152 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
138 Downloads (Pure)

Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots

Hill, S., Sheikh, S., Zhang, Q., Sueiro Ballesteros, L., Herman, A., Davies, S. A., Berry, M., Benito-Alifonso, D. & Galan, C., 15 Jul 2019, In : Nanoscale Advances. 1, 8, p. 2840-2846 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
149 Downloads (Pure)

Sequential Photochemical and Prins Reactions for the Diastereoselective Synthesis of Tricyclic Scaffolds

Donnelly, B., Elliott, L., Willis, C. & Booker-Milburn, K., 24 May 2019, In : Angewandte Chemie - International Edition. 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
38 Downloads (Pure)

Stabilizing and Understanding a Miniprotein by Rational Redesign

Porter Goff, K., Nicol, D., Williams, C., Crump, M., Zieleniewski, F., Samphire, J., Baker, E. & Woolfson, D., 16 Jul 2019, In : Biochemistry. 58, 28, p. 3060-3064 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Downloads (Pure)

Structural and Synthetic Studies on Maleic Anhydride and Related Diacid Natural Products.

Heard, D. M., Cox, R., Simpson, T. J. & Willis, C. L., 18 Oct 2019, (Accepted/In press) In : Tetrahedron.

Research output: Contribution to journalArticle (Academic Journal)

The surprisingly facile formation of Pd(I)-phosphido complexes from ortho-biphenylphosphines and palladium acetate

Montgomery, M., O'Brien, H. M., Méndez-Gálvez, C., Bromfield, C. R., Roberts, J. P. M., Winnicka, A. M., Horner, A., Elorriaga, D., Sparkes, H. A. & Bedford, R. B., 25 Jan 2019, In : Dalton Transactions. 48, 11, p. 3539-3542 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
75 Downloads (Pure)

Towards functional de novo designed proteins

Dawson, W., Rhys, G. & Woolfson, D., 1 Oct 2019, In : Current Opinion in Chemical Biology. 52, p. 102-111 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
257 Downloads (Pure)

Uniform Biodegradable Fiber-Like Micelles and Block Comicelles via "living" Crystallization-Driven Self-Assembly of Poly(l -lactide) Block Copolymers: The Importance of Reducing Unimer Self-Nucleation via Hydrogen Bond Disruption

He, Y., Eloi, J. C., Harniman, R. L., Richardson, R. M., Whittell, G. R., Mathers, R. T., Dove, A. P., O'Reilly, R. K. & Manners, I., 4 Dec 2019, In : Journal of the American Chemical Society. 141, 48, p. 19088-19098 11 p.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Vinylidene Homologation of Boronic Esters and its Application to the Synthesis of the Proposed Structure of Machillene

Fordham, J. M., Grayson, M. N. & Aggarwal, V. K., 21 Oct 2019, In : Angewandte Chemie - International Edition. 58, 43, p. 15268-15272 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
23 Downloads (Pure)
2018

1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides

Adam, M. K., Jarrett-Wilkins, C., Beards, M., Staykov, E., MacFarlane, L. R., Bell, T. D. M., Matthews, J. M., Manners, I., Faul, C. F. J., Moens, P. D. J., Ben, R. N. & Wilkinson, B. L., 4 Jun 2018, In : Chemistry - A European Journal. 24, 31, p. 7834-7839 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
253 Downloads (Pure)

Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes

Dias, C. M., Li, H., Valkenier, H., Karagiannidis, L. E., Gale, P. A., Sheppard, D. N. & Davis, A. P., 21 Feb 2018, In : Organic and Biomolecular Chemistry. 16, 7, p. 1083-1087 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
25 Citations (Scopus)
234 Downloads (Pure)

Anthracene Bisureas as Powerful and Accessible Anion Carriers

Dias, C. M., Valkenier, H. & Davis, A. P., 20 Apr 2018, In : Chemistry - A European Journal. 24, 23, p. 6262-6268 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
196 Downloads (Pure)

A Transient Vinylphosphinidene via a Phosphirene-Phosphinidene Rearrangement

Liu, L. L., Zhou, J., Cao, L. L., Andrews, R., Falconer, R. L., Russell, C. A. & Stephan, D. W., 10 Jan 2018, In : Journal of the American Chemical Society. 140, 1, p. 147-150 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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21 Citations (Scopus)
260 Downloads (Pure)

Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages

Galloway, J. M., Senior, L., Fletcher, J. M., Beesley, J. L., Hodgson, L. R., Harniman, R. L., Mantell, J. M., Coombs, J., Rhys, G. G., Xue, W-F., Mosayebi, M., Linden, N., Liverpool, T. B., Curnow, P., Verkade, P. & Woolfson, D. N., 27 Feb 2018, In : ACS Nano. 12, 2, p. 1420–1432 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
215 Downloads (Pure)

Cloning, Expression and Purification of Intact Polyketide Synthase Modules

Maschio, L., Parnell, A., Lees, N. R., Willis, C., Berger-Schaffitzel, C., Stach, J. E. M. & Race, P., 31 Oct 2018, (Accepted/In press) [forthcoming Methods in Enzymology volume]. Elsevier Inc., Vol. 617. p. 63-82 20 p. (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Consecutive Ring Expansion and Contraction for the Synthesis of 1-Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors

Hill, J. E., Matlock, J. V., Lefebvre, Q., Cooper, K. G. & Clayden, J., 14 May 2018, In : Angewandte Chemie - International Edition. 57, 20, p. 5788-5791 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Citations (Scopus)
155 Downloads (Pure)

De novo coiled-coil peptides as scaffolds for disrupting protein-protein interactions

Fletcher, J., Horner, K. A., Bartlett, G., Rhys, G., Wilson, A. J. & Woolfson, D., 7 Aug 2018, In : Chemical Science. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
347 Downloads (Pure)

De Novo-Designed α-Helical Barrels as Receptors for Small Molecules

Thomas, F., Dawson, W., Lang, E., Burton, A., Bartlett, G., Rhys, G., Mulholland, A. & Woolfson, D., 20 Jul 2018, In : ACS Synthetic Biology. 7, 7, p. 1808-1816 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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18 Citations (Scopus)
198 Downloads (Pure)

G-quadruplexes in Prague: A Bohemian Rhapsody

O'Hagan, M. P., Mergny, J. L. & Waller, Z. A. E., 1 Apr 2018, In : Biochimie. 147, p. 170-180 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
216 Downloads (Pure)