Faculty of Life Sciences

  • BS8 8DZ

    United Kingdom

Research Output

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Article (Academic Journal)
2020

5′ modifications to CRISPR Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

Mullally, G. E. L., Van Aelst, K., Mubarak Naqvi, M., Diffin, F. M., Karvelis, T., Gasiunas, G., Siksnys, V. & Szczelkun, M. D., 4 Jun 2020, In : Nucleic Acids Research. 13 p., gkaa477.

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A bat guano deposit in Jamaica recorded agricultural changes and metal exposure over the last >4300 years

Gallant, L. R., Grooms, C., Kimpe, L. E., Smol, J. P., Bogdanowicz, W., Stewart, R. S., Clare, E. L., Fenton, M. B. & Blais, J. M., 15 Jan 2020, In : Palaeogeography, Palaeoclimatology, Palaeoecology. 538, 7 p., 109470.

Research output: Contribution to journalArticle (Academic Journal)

A Bayesian predictive approach for dealing with pseudoreplication

Lazic, S. E., Mellor, J. R., Ashby, M. C. & Munafo, M. R., 11 Feb 2020, In : Scientific Reports. 10, 10 p., 2366 (2020).

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2 Citations (Scopus)
48 Downloads (Pure)

A body in nonlinear near-wall shear flow: impacts, analysis and comparisons

Palmer, R. A. & Smith, F., 25 Jul 2020, (Accepted/In press) In : Journal of Fluid Mechanics.

Research output: Contribution to journalArticle (Academic Journal)

Above- and below-ground biodiversity jointly regulate temperate forest multifunctionality along a local-scale environmental gradient

Yuan, Z., Ali, A., Ruiz-Benito, P., Jucker, T., Mori, A. S., Wang, S., Zhang, X., Li, H., Hao, Z., Wang, X. & Loreau, M., 16 Mar 2020, In : Journal of Ecology. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

A Cambrian–Ordovician terrestrialization of arachnids

Lozano-Fernandez, J., Tanner, A., Puttick, M. N., Vinther, J., Edgecombe, GD. & Pisani, D., 11 Mar 2020, In : Frontiers in Genetics.

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Acculturation coping leads to heightened sensitivity to socially hurtful events

Lu, M., Hamamura, T., Chan, M., Li, C. & Park, J. H., 25 Mar 2020, In : Basic and Applied Social Psychology. 42, 4, p. 295-304 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Acquisition of aspect in L2: The computation of event completion by Japanese learners of English

Kaku-Macdonald, K., Liceras, J. M. & Kazanina, N., 22 Jan 2020, In : Applied Psycholinguistics. 41, 1, p. 185-214 30 p.

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Activation by sub-stoichiometric inhibition

Merdanovic, M., Burston, S. G., Schmitz, A. L., Köcher, S., Knapp, S., Clausen, T., Kaiser, M., Huber, R. & Ehrmann, M., 21 Jan 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1414-1418 5 p.

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Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept

Santopaolo, M., Sullivan, N., Thomas, A. C., Alvino, V. V., Nicholson, L. B., Gu, Y., Spinetti, G., Kallikourdis, M., Blom, A. W. & Madeddu, P. R., 3 Jul 2020, (Submitted) In : Diabetologia.

Research output: Contribution to journalArticle (Academic Journal)

Activation of C-Reactive Protein Proinflammatory Phenotype in the blood retinal barrier in vitro: Implications for Age-related Macular Degeneration

Romero-Vázquez, S., Adán, A., Figueras-Roca, M., Llorenç, V., Slevin, M., Vilahur, G., Badimon, L., Dick, A. D. & Molins, B., 16 Jul 2020, In : Aging. 12, 19 p.

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Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting

Evans, A. J., Daly, J., Anuar, A. N. K., Simonetti, B. & Cullen, P. J., 3 Aug 2020, In : Journal of Cell Science. 133, jcs246033.

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A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase

Stenner, R., Steventon, J. W., Seddon, A. & Anderson, J. L. R., 21 Jan 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1419-1428 10 p.

Research output: Contribution to journalArticle (Academic Journal)

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4 Citations (Scopus)
74 Downloads (Pure)

A draft genome sequence of the elusive giant squid, Architeuthis dux

da Fonseca, R. R., Couto, A., Machado, A. M., Brejova, B., Albertin, C. B., Silva, F., Gardner, P., Baril, T., Hayward, A., Campos, A., Ribeiro, Â. M., Barrio-Hernandez, I., Hoving, H-J., Tafur-Jimenez, R., Chu, C., Frazão, B., Petersen, B., Peñaloza, F., Musacchia, F., Alexander, G. C. & 24 others, Osório, H., Winkelmann, I., Simakov, O., Rasmussen, S., Rahman, M. Z., Pisani, D., Vinther, J., Jarvis, E., Zhang, G., Strugnell, J. M., Castro, L. F. C., Fedrigo, O., Patricio, M., Li, Q., Rocha, S., Antunes, A., Wu, Y., Ma, B., Sanges, R., Vinar, T., Blagoev, B., Sicheritz-Ponten, T., Nielsen, R. & Gilbert, M. T. P., 16 Jan 2020, In : GigaScience. 9, 1, 12 p., giz152.

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Agrin-mediated cardiac regeneration: some open questions

Bigotti, M. G., Skeffington, K. L., Jones, F. P., Caputo, M. & Brancaccio, A., 16 Jun 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 8 p., 594.

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A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

Anton, Z., Betin, V. M. S., Simonetti, B., Traer, C. J., Attar, N., Cullen, P. J. & Lane, J. D., 15 Jul 2020, In : Journal of Cell Science. 133, 14, 38 p., jcs246306.

Research output: Contribution to journalArticle (Academic Journal)

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Airway management for dental clearance in a preschool child: A UK survey

Shrimpton, A. J. & Gill, H., 16 Apr 2020, (Accepted/In press) In : Paediatric Anaesthesia.

Research output: Contribution to journalArticle (Academic Journal)

Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study

Fernandes, G. S., Hammerton, G. L., Abeysekera, K. W. M., Mahedy, L. L., A, E., Lewis, G., Hickman, M. & Heron, J. E., 6 Jul 2020, In : Journal of Epidemiology and Community Health. 5 p.

Research output: Contribution to journalArticle (Academic Journal)

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Alcohol use and cognitive functioning in young adults: improving causal inference

Mahedy, L., Suddell, S., Skirrow, C., Fernandes, G. S., Field, M., Heron, J., Hickman, M., Wootton, R. & Munafò, M. R., 13 Apr 2020, (Accepted/In press) In : Addiction.

Research output: Contribution to journalArticle (Academic Journal)

Alemtuzumab-related eosinophilic central nervous system vasculitis

Leach, O. A., Hilton, D. A., Adams, W., Love, S. & Straukiene, A., 21 Feb 2020, In : Multiple Sclerosis Journal. 4 p.

Research output: Contribution to journalArticle (Academic Journal)

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Algal photophysiology drives darkening and melt of the Greenland Ice Sheet

Williamson, C. J., Cook, J., Tedstone, A., Yallop, M., McCutcheon, J., Poniecka, E., Campbell, D., Irvine-Fynn, T., McQuaid, J., Tranter, M., Perkins, R. & Anesio, A., 17 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 11, p. 5694-5705 12 p.

Research output: Contribution to journalArticle (Academic Journal)

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A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 14 Apr 2020, In : Autophagy. 17 p.

Research output: Contribution to journalArticle (Academic Journal)

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A More Granular View of Neutrophils in Malaria

Amulic, B., Moxon, C. A. & Cunnington, A. J., 1 Jun 2020, In : Trends in Parasitology. 36, 6, p. 501-503 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Ancestral hybridisation facilitated species diversification in the Lake Malawi cichlid fish adaptive radiation

Svardel, H., Quah, F. X., Malinsky, M., Ngatunga, B. P., Miska, E. A., Salzburger, W., Genner, M. J., Turner, G. F. & Durbin, R., 1 Apr 2020, In : Molecular Biology and Evolution. 14 p., msz294.

Research output: Contribution to journalArticle (Academic Journal)

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114 Downloads (Pure)
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An information theoretic approach to insulin sensing by human kidney podocytes

Pope, R. JP., Garner, K. L., Voliotis, M., Lay, A. C., Betin, V. MS., Tsaneva-Atanasova, K., Welsh, G. I., Coward, R. JM. & McArdle, C. A., 1 Aug 2020, In : Molecular and Cellular Endocrinology. 110976.

Research output: Contribution to journalArticle (Academic Journal)

An Open Label Pilot Study of a Brief Psychosocial Intervention for Disaster and Trauma Survivors

O'Donnell, M. L., Lau, W., Fredrickson, J., Gibson, K., Bryant, R. A., Bisson, J., Burke, S., Busuttil, W., Coghlan, A., Creamer, M., Gray, D., Greenberg, N., McDermott, B., McFarlane, A. C., Monson, C. M., Phelps, A., Ruzek, J. I., Schnurr, P. P., Ugsang, J., Watson, P. & 4 others, Whitton, S., Williams, R., Cowlishaw, S. & Forbes, D., 27 Jun 2020, In : Frontiers in Psychiatry. 11, p. 483

Research output: Contribution to journalArticle (Academic Journal)

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Open Access
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A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 20 Jan 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 224-236 13 p.

Research output: Contribution to journalArticle (Academic Journal)

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76 Downloads (Pure)

A 'no' with a trace of 'yes': a mouse-tracking study of negative sentence processing

Darley, E. J., Kent, C. & Kazanina, N., 1 May 2020, In : Cognition. 198, 104084.

Research output: Contribution to journalArticle (Academic Journal)

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Anthoceros genomes illuminate the origin of land plants and the unique biology of hornworts

Li, F-W., Nishiyama, T., Waller, M., Frangedakis, E., Keller, J., Li, Z., Fernandez-Pozo, N., Barker, M. S., Bennett, T. A., Blazquez, M. A., Cheng, S., Cuming, A., de Vries, J., de Vries, S., Delaux, P-M., Diop, I. S., Harrison, C. J., Hauser, D., Hernandez-Garcia, J., Kirbis, A. & 14 others, Meeks, J., Monte, I., Mutte, S. K., Neubauer, A., Quandt, D., Robison, T., Shimamura, M., Rensing, S., Villareal, J. C., Weijers, D., Wicke, S., Wong, G. K-S., Sakakibara, K. & Szövényi, P., 13 Mar 2020, In : Nature Plants. 6, p. 259–272

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Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress

Jenkins, J. J., Mantell, J. M., Neal, C. R., Gholinia, A., Verkade, P., Nobbs, A. H. & Su, B., 2 Apr 2020, In : Nature Communications. 14 p., 1626 (2020) .

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An update on the structure of hERG

Butler, A., Helliwell, M. V., Zhang, Y., Hancox, J. C. & Dempsey, C. E., 24 Jan 2020, In : Frontiers in Pharmacology. 10, 13 p., 1572.

Research output: Contribution to journalArticle (Academic Journal)

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A phylogenomic analysis of Nepenthes (Nepenthaceae)

Murphy, B., Forest, F., Barraclough, T., Rosindell, J., Bellot, S., Cowan, R., Golos, M., Jebb, M. & Cheek, M., 1 Mar 2020, In : Molecular Phylogenetics and Evolution. 144, 23 p., 106668.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, In : ACS Chemical Biology. 2020, 10 p.

Research output: Contribution to journalArticle (Academic Journal)

A qualitative study of e-cigarette emergence and the potential for renormalisation of smoking in UK youth

Brown, R., Bauld, L., de Lacy, E., Hallingberg, B., Maynard, O., McKell, J., Moore, L. & Moore, G., 1 Jan 2020, In : International Journal of Drug Policy. 75, 9 p., 102598.

Research output: Contribution to journalArticle (Academic Journal)

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A qualitative study on conveyance decision-making during emergency call outs to people with dementia: The HOMEWARD project

Voss, S., Brandling, J., Pollard, K., Taylor, H., Black, S., Buswell, M., Cheston, R., Cullum, S., Foster, T., Kirby, K., Prothero, L., Purdy, S., Solway, C. & Benger, J., 29 Jan 2020, In : BMC Emergency Medicine. 20, 1, 9 p., 6 (2020).

Research output: Contribution to journalArticle (Academic Journal)

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A rapid, neural measure of implicit recognition memory using fast periodic visual stimulation

Stothart, G., Smith, L. J. & Milton, A., 1 May 2020, In : NeuroImage. 211, 10 p., 116628.

Research output: Contribution to journalArticle (Academic Journal)

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A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours

Adams, C. L., Ercolano, E., Ferluga, S., Sofela, A., Dave, F., Negroni, C., Kurian, K. M., Hilton, D. A. & Hanemann, C. O., 13 Feb 2020, In : International Journal of Molecular Sciences. 21, 4

Research output: Contribution to journalArticle (Academic Journal)

Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK

POIG Uveitis Delphi Group, 1 Jan 2020, In : British Journal of Ophthalmology. 104, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
200 Downloads (Pure)

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

Macleod, O. J. S., Bart, J-M., MacGregor, P., Peacock, L., Hester, S., Ravel, S., Sunter, J. D., Trevor, C., Rust, S., Vaughan, T. J., Minter, R., Mohammed, S., Gibson, W., Taylor, M. C., Higgins, M. K. & Carrington, M., 12 Mar 2020, In : Nature Communications. 11, 12 p., 1326 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
66 Downloads (Pure)

A research agenda for microclimate ecology in human-modified tropical forests

Jucker, T., Jackson, T., Florian, Z., Swinfield, T., Gregory, N., Williamson, J., Slade, E., Phillips, J., Bittencourt, P., Blonder, B., Boyle, M., Ellwood, M. D. F., Hemprich-Bennett, D., Lewis, O., Matula, R., Senior, R., Shenkin, A., Svátek, M. & Coomes, D., 17 Jan 2020, In : Frontiers in Forests and Global Change.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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Are there any ‘object detectors’ in the hidden layers of CNNs trained to identify objects or scenes?

Gale, E. M., Martin, N., Blything, R., Nguyen, A. & Bowers, J. S., 22 Jun 2020, (Accepted/In press) In : Vision Research.

Research output: Contribution to journalArticle (Academic Journal)

A role for NPY-NPY2R signaling in albuminuric kidney disease

Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C., McArdle, C. A. & 2 others, Welsh, G. I. & Coward, R. J. M., 19 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 12 p., 202004651.

Research output: Contribution to journalArticle (Academic Journal)

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A small membrane stabilising protein critical to the pathogenicity of Staphylococcus aureus

Duggan, S., Alnahari, A., Bacon, L., Massey, R. C. & al., E., 9 Jun 2020, (Accepted/In press) In : Infection and Immunity.

Research output: Contribution to journalArticle (Academic Journal)

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Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

Marina, N., Christie, I. N., Korsak, A., Doronin, M., Brazhe, A., Hosford, P. S., Wells, J. A., Sheikhbahaei, S., Humoud, I., Paton, J. F. R., Lythgoe, M. F., Semyanov, A., Kasparov, S. & Gourine, A. V., 9 Jan 2020, In : Nature Communications. 11, 1, 9 p., 131 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
65 Downloads (Pure)