Organization profile

Organisation profile

Our research is driven by a commitment to fundamental studies of the molecular processes that form the basis of life. We place a particular emphasis on the quantitative analysis of biomolecular mechanisms such that these systems can be harnessed and modified in a predictive manner. Our work exploits both in vitro and in vivo systems to fully understand human health and disease, and to initiate development of diagnostics and effective therapeutics.

Core strengths include: temporal and mechanistic studies of enzyme systems; DNA-protein interactions; membrane function including membrane protein folding, transporters and receptors; and the cellular dynamics by which membrane contents are delivered, assembled and recycled. Although fully coherent in itself, much of our research also informs, and is further developed by, surrounding research and clinical activity within Bristol, including University-wide thematic areas of neuroscience, cardiovascular research, cancer, regenerative medicine, infection and immunity, and synthetic biology.

Fingerprint Dive into the research topics where Fundamental Bioscience is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    5′ modifications to CRISPR Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

    Mullally, G. E. L., Van Aelst, K., Mubarak Naqvi, M., Diffin, F. M., Karvelis, T., Gasiunas, G., Siksnys, V. & Szczelkun, M. D., 4 Jun 2020, In : Nucleic Acids Research. 13 p., gkaa477.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 8 Downloads (Pure)

    A Bayesian predictive approach for dealing with pseudoreplication

    Lazic, S. E., Mellor, J. R., Ashby, M. C. & Munafo, M. R., 11 Feb 2020, In : Scientific Reports. 10, 10 p., 2366 (2020).

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 2 Citations (Scopus)
    46 Downloads (Pure)

    A Bioinspired Strategy for the Enantioselective Synthesis of Bicyclic Oxygen Heterocycles

    Rodriguez Venegas, E. & Willis, C. L., 16 Mar 2020, In : Organic Letters. 5 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Projects

    Student theses

    An Alternative Approach to Combat Antimicrobial Resistant Infections of Medical Implants and Devices

    Author: Jenkins, J. J., 28 Nov 2019

    Supervisor: Nobbs, A. (Supervisor), Su, B. (Supervisor) & Verkade, P. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Biocrystals: Growth, Synthesis and Materials

    Author: Abu El Magd, N., 31 Mar 2020

    Supervisor: Patil, A. (Supervisor) & Anderson, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Blood pressure control during exercise in people with hypertension

    Author: Chant, B., 23 Jan 2019

    Supervisor: Paton, J. (Supervisor) & Hart, E. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Activities

    • 2 Participation in workshop, seminar, course
    • 1 Fellowship awarded competitively
    • 1 Visiting an external academic institution

    KEMRI

    Paul R Race (Visiting researcher)

    13 Jul 201820 Jul 2018

    Activity: Visiting an external institution typesVisiting an external academic institution

    Computationally Directed Protein Design Workshop

    Dek Woolfson (Participant), , Fabio Parmeggiani (Participant), , Ross Anderson (Participant), , Kathleen Sedgley (Participant), & Tom Bowker (Participant)

    2018

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    International Genetically Engineered Microorganism (iGEM) Jamboree 2017

    Kathleen R Sedgley (Participant), , Paul Curnow (Organiser), , Fabio Parmeggiani (Organiser), & Andy Boyce (Organiser)

    1 Jun 201730 Nov 2017

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course