Insulin-like Growth Factors and Metabolic Endocrinology Group

  • United Kingdom

Organization profile

Organisation profile

Our research at the Insulin-like Growth Factors and Metabolic Endocrinology Group (IMEG) is focused on how nutrition and metabolism contribute to the development of major chronic disorders, with a specific interest in the role of insulin-like growth factors.

Insulin-like growth factors (IGFs), together with insulin, are fundamental, nutritionally-dependent regulators of growth and metabolism. Many of the major chronic illnesses that increasingly burden our health services have been linked to a Western diet and lifestyle and are far less prevalent in large regions of the world .

We have been investigating the biology of IGFs and related factors and how they may mediate the effects of nutrition on chronic illness. Our research includes cell biology studies, translational clinical investigations and population epidemiology. We have focused on the major epithelial cancers and on obesity and more recently on interactions between these two conditions.

Fingerprint Dive into the research topics where Insulin-like Growth Factors and Metabolic Endocrinology Group is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

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    Research Output

    BCATC modulates crosstalk between the PIK/AKT and the RAS/ERK pathway regulating proliferation in triple negative breast cancer

    Shafei, M., Forshaw, T., Davis, J., Flemban, A., Qualtrough, J. D., Dean, S., Perks, C. M., Dong, M., Newman, R. & Conway, M., 14 Apr 2020, (Accepted/In press) In : Oncotarget.

    Research output: Contribution to journalArticle (Academic Journal)

  • IGF-1 and Hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells

    Mansor, R., Holly, J. M. P., Barker, R. M., Biernacka, K. M., Zielinska, H. A., Koupparis, A. J., Rowe, E., Oxley, J., Sewell, A., Martin, R. M., Lane, J. A., Hackshaw-McGeagh, L. & Perks, C. M., 30 May 2020, (Accepted/In press) In : Oncotarget.

    Research output: Contribution to journalArticle (Academic Journal)

  • Mini review: Opposing pathologies in cancer and Alzheimer's disease: Does the PI3K/Akt pathway provide clues?

    Barker, RM., Holly, J. M. P., Biernacka, K. M., Allen-Birt, S. J. A. & Perks, C. M., 23 Jun 2020, In : Frontiers in Endocrinology. p. 1-9 9 p., 403.

    Research output: Contribution to journalArticle (Academic Journal)

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    Student theses

    Does the IGF axis influence EMT to play a role in bladder cancer progression?

    Author: Tang, S., 23 Jan 2019

    Supervisor: Perks, C. (Supervisor) & Holly, J. M. P. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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    Examining the Role of Placental-derived MicroRNA Secretions in Response to Gestational Hypoxia on Foetal Neurodevelopment

    Author: Bignell, A. L., 23 Jan 2020

    Supervisor: Case, C. P. (Supervisor), Perks, C. M. (Supervisor), Uney, J. B. (Supervisor) & Fulga, T. A. (External person) (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

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    Repositioning aspirin and metformin to improve prostate cancer treatment and outcome

    Author: Carr, H., 19 Mar 2019

    Supervisor: Perks, C. (Supervisor), Williams, A. (Supervisor), Holly, J. M. P. (Supervisor) & Martin, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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