MRC Integrative Epidemiology Unit

  • BS8 2BN

    United Kingdom

Research Output

2020

A Bayesian predictive approach for dealing with pseudoreplication

Lazic, S. E., Mellor, J. R., Ashby, M. C. & Munafo, M. R., 11 Feb 2020, In : Scientific Reports. 10, 10 p., 2366 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
50 Downloads (Pure)

A comparison of the associations between adiposity and lipids in Malawi and the United Kingdom

Soares, A. L. G., Banda, L., Amberbir, A., Jaffar, S., Musicha, C., Price, A. J., Crampin, A. C., Nyirenda, M. J. & Lawlor, D. A., 16 Jul 2020, In : BMC Medicine. 18, 13 p., 181 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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30 Downloads (Pure)

ADHD and depression: investigating a causal explanation

Riglin, L., Leppert, B., Dardani, C., Thapar, A., Rice, F., O'Donovan, M. C., Davey Smith, G., Stergiakouli, E., Tilling, K. M. & Thapar, A., 6 Apr 2020, In : Psychological Medicine. p. 1 - 8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Adverse childhood experiences, DNA methylation age acceleration and cortisol in UK children: a prospective population-based cohort study

Tang, R., Howe, L. D., Suderman, M. J., Relton, C. L., Crawford, A. A. & Houtepen, L. C., 7 Apr 2020, In : Clinical Epigenetics. 12, 9 p., 55 (2020).

Research output: Contribution to journalArticle (Academic Journal)

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41 Downloads (Pure)

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

Marini, S., Davis, K. A., Soare, T. W., Zhu, Y., Suderman, M. J., Simpkin, A. J., Smith, A. D. A. C., Wolf, E. J., Relton, C. L. & Dunn, E. C., 1 Mar 2020, In : Psychoneuroendocrinology. 113, 104484.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Age at period cessation and trajectories of cardiovascular risk factors across mid and later life

O'Keefe, L. M., Kuh, D., Fraser, A., Howe, L. D., Lawlor, D. & Hardy, R., 25 Feb 2020, In : Heart. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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67 Downloads (Pure)

A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data

Huynh-Le, M-P., Fan, C. C., Karunamuni, R., Walsh, E. I., Turner, E. L., Lane, J. A., Martin, R. M., Neal, D., Donovan, J. L., Hamdy, F. C., Parsons, J. K., Eeles, R. A., Easton, D. F., Kote-Jarai, Z., Olama, A. A. A., Benlloch, S., Muir, K. R., Gronberg, H., Wiklund, F., Aly, M. & 42 others, Schleutker, J., Sipeky, C., Tammela, T. L. J., Nordestgaard, B. G., Key, T. J., Travis, R. C., Pharoah, P., Pashayan, N., Khaw, K-T., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Maier, C., Vogel, W., Luedeke, M., Herkommer, K., Kibel, A. S., Cybulski, C., Wokolorczyk, D., Kluzniak, W., Cannon-Albright, L., Brenner, H., Schöttker, B., Holleczek, B., Park, J. Y., Sellers, T. A., Lin, H. Y., Slavov, C., Kaneva, R., Mitev, V., Batra, J., Clements, J., Spurdle, A., Teixeira, M. R., Paulo, P., Maia, S., Pandha, H., Michael, A., Mills, I. G., Andreassen, O. A., Dale, A. M. & Seibert, T. M., 24 Jun 2020, In : Cancer Epidemiology, Biomarkers and Prevention.

Research output: Contribution to journalArticle (Academic Journal)

Age-of-onset information helps identify 76 genetic variants associated with allergic disease

Ferreira, M. A. R., Granell, R., Brumpton, B. M., Paternoster, L. & al., E., 20 Mar 2020, (Accepted/In press) In : PLoS Genetics.

Research output: Contribution to journalArticle (Academic Journal)

Alcohol use and cognitive functioning in young adults: improving causal inference

Mahedy, L., Suddell, S., Skirrow, C., Fernandes, G. S., Field, M., Heron, J., Hickman, M., Wootton, R. & Munafò, M. R., 13 Apr 2020, (Accepted/In press) In : Addiction.

Research output: Contribution to journalArticle (Academic Journal)

Allergy, asthma, and the risk of breast and prostate cancer: a Mendelian randomization study

Jiang, X., Dimou, N. L., Zhu, Z., Bonilla, C., Lewis, S. J., Lindström, S., Kraft, P., Tsilidis, K. K., Martin, R. M. & PRACTICAL, CRUK, BPC3, CAPS and PEGASUS consortia, 31 Jan 2020, In : Cancer Causes and Control. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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113 Downloads (Pure)

A maternal serum metabolite ratio predicts fetal growth restriction at term

Sovio, U., Goulding, N., McBride, N., Cook, E., Gaccioli, F., Charnock-Jones, D. S., Lawlor, D. A. & Smith, G. C. S., 11 Mar 2020, In : Nature Medicine. 26, p. 348-353 6 p.

Research output: Contribution to journalArticle (Academic Journal)

A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia

Jones, H. J., Martin, D., Lewis, S. J., Davey Smith, G., O'Donovan, M. C., Owen, M. J., Walters, J. T. R. & Zammit, S., 24 Jun 2020, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Downloads (Pure)
Open Access
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13 Downloads (Pure)

An independent locus upstream of ASIP controls variation in the shade of the bay coat colour in horses

Corbin, L. J., Pope, J., Sanson, J., Antczak, D., Miller, D., Sadeghi, R. & Brooks, S., 30 May 2020, In : Genes. (2020) 11, 606, 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Downloads (Pure)

A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder.

Sullivan, S. A., Kounali, D-Z., Cannon, M., David, A. S., Fletcher, P., Holmans, P. A., Jones, H., Jones, P. B., Linden, D. E. J., Lewis, G. H., Owen, M. J., O'Donovan, M. C., Rammos, A., Thompson, A., Wolke, D. & Zammit, S., 7 Jan 2020, In : American Journal of Psychiatry. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

A qualitative study of e-cigarette emergence and the potential for renormalisation of smoking in UK youth

Brown, R., Bauld, L., de Lacy, E., Hallingberg, B., Maynard, O., McKell, J., Moore, L. & Moore, G., 1 Jan 2020, In : International Journal of Drug Policy. 75, 9 p., 102598.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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104 Downloads (Pure)

Assessment of a causal relationship between body mass index and atopic dermatitis

Budu-Aggrey, A., Watkins, S. H., Brumpton, B. M., Løset, M., Tyrrell, J., Modalsli, E. H., Vie, G. Å., Palmer, T., Fritsche, L. G., Nielsen, J. B., Romundstad, P. R., Davey Smith, G., Åsvold, B. O., Paternoster, L. & Brown, S. J., 17 Apr 2020, In : Journal of Allergy and Clinical Immunology. 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Downloads (Pure)

Association of Assisted Reproductive Technologies with offspring cord blood DNA methylation across cohorts.

Caramaschi, D., 2020, In : medRxiv.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
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160 Downloads (Pure)

Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis

Degerud, E., Høiseth, G., Mørland, J., Ariansen, I., Graff-Iversen, S., Ystrom, E., Zuccolo, L. & Næss, Ø., 3 Feb 2020, In : PLoS Medicine. 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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48 Downloads (Pure)
Open Access
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31 Downloads (Pure)

Association of the functional ovarian reserve with serum metabolomic profiling by nuclear magnetic resonance spectroscopy: A cross sectional study of ~400 women

Al Rashid, K., Taylor, A. E., Lumsden, M. A., Goulding, N. J., Lawlor, D. A. & Nelson, S., 7 Jul 2020, (Accepted/In press) In : BMC Medicine.

Research output: Contribution to journalArticle (Academic Journal)

Associations Between High Blood Pressure and DNA Methylation

Kazmi, N., Elliott, H. R., Burrows, K., Tillin, T., Hughes, A. D., Chaturvedi, N., Gaunt, T. R. & Relton, C. L., 30 Jan 2020, In : PLoS ONE. 15, 1, 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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66 Downloads (Pure)

Associations between prenatal indicators of mechanical loading and proximal femur shape: findings from a population-based study in ALSPAC offspring

Frysz, M., Tobias, J. H., Lawlor, D. A., Aspden, R. M., Gregory, J. & Ireland, A., 30 Mar 2020, (Accepted/In press) In : Journal of Musculoskeletal and Neuronal Interactions.

Research output: Contribution to journalArticle (Academic Journal)

1 Downloads (Pure)

Associations of body mass index, physical activity and sedentary time with blood pressure in primary school children from south-west England: a prospective study

Solomon-Moore, E., Salway, R., Emm-Collison, L., Thompson, J. L., Sebire, S. J., Lawlor, D. A. & Jago, R., 29 Apr 2020, In : PLoS ONE. 15, 4, 14 p., e0232333.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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20 Downloads (Pure)
Open Access
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88 Downloads (Pure)
Open Access
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1 Citation (Scopus)
71 Downloads (Pure)

Avoidance of tobacco health warnings? An eye-tracking approach

Sillero-Rejon, C., Leonards, U., Munafò, M. R., Maynard, O. M. & al., E., 7 Jun 2020, In : Addiction. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Downloads (Pure)

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Brumpton, B., Sanderson, E., Heilbron, K., Hartwig, F. P., Harrison, S., Vie, G. Å., Cho, Y., Howe, L. D., Hughes, A., Boomsma, D. I., Havdahl, A., Hopper, J. L., Neale, M., Nivard, M. G., Pedersen, N. L., Reynolds, C., Tucker-Drob, E. M., Howe, L., Morris, T., Lin, S. & 14 others, The Within-family Consortium, the 23 and Me Research Team, Auton, A., Windmeijer, F., Chen, W-M., Bjørngaard, J. H., Hveem, K., Willer, C. J., Evans, D. M., Kaprio, J. A., Davey Smith, G., Åsvold, B. O., Hemani, G. & Davies, N. M., 14 Jul 2020, In : Nature Communications. 11, 13 p., 3519 (2020) .

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Downloads (Pure)
Open Access
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27 Downloads (Pure)

Bayesian reassessment of the epigenetic architecture of complex traits

Trejo Banos, D., McCartney, D. L., Patxot, M., Anchieri, L., Battram, T., Christiansen, C., Costeira, R., Walker, R. M., Morris, S. W., Campbell, A., Zhang, Q., Porteous, D. J., McRae, A. F., Wray, N. R., Visscher, P. M., Haley, C. S., Evans, K. L., Deary, I. J., McIntosh, A. M., Hemani, G. & 3 others, Bell, J. T., Marioni, R. E. & Robinson, M. R., 8 Jun 2020, In : Nature Communications. 11, 1, p. 2865

Research output: Contribution to journalArticle (Academic Journal)

Bi-directional effects between loneliness, smoking and alcohol use: Evidence from a Mendelian randomisation study

Wootton, R. E., Munafo, M. R., Treur, J. L. & al., E., 29 Jun 2020, In : Addiction. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Downloads (Pure)

Biotic analogies for self-organising cities

Narraway, C. L., Davis, O. S. P., Lowell, S., Lythgoe, K. A., Turner, J. S. & Marshall, S., 1 Feb 2020, In : Environment and Planning B: Urban Analytics and City Science. 47, 2, p. 268-286 19 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
1 Citation (Scopus)

Can education be personalised using pupils' genetic data?

Morris, T. T., Davies, N. M. & Davey Smith, G., 10 Mar 2020, In : eLife. 9, 18 p., e49962.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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33 Downloads (Pure)

Can genetics reveal the causes and consequences of educational attainment?

Munafò, M., Davies, N. M. & Davey Smith, G., 1 Feb 2020, In : Journal of the Royal Statistical Society: Series A. 183, 2, p. 681-688 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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69 Downloads (Pure)

Causal relationships between lipid and glycemic levels in an Indian population: A bidirectional Mendelian randomization approach

Agarwal, T., Lyngdoh, T., Dudbridge, F., Chandak, G. R., Kinra, S., Prabhakaran, D., Reddy, K. S., Relton, C. L., Davey Smith, G., Ebrahim, S., Gupta, V. & Walia, G. K., 29 Jan 2020, In : PLoS ONE. 15, 1, p. e0228269

Research output: Contribution to journalArticle (Academic Journal)

Changes of DNA methylation are associated with changes in lung function during adolescence

Sunny, S. K., Zhang, H., Rezwan, F. I., Relton, C. L., Henderson, A. J., Merid, S. K., Melén, E., Hallberg, J., Arshad, S. H., Ewart, S. & Holloway, J. W., 7 Apr 2020, In : Respiratory Research. 21, 1, p. 80

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Downloads (Pure)
Open Access
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44 Downloads (Pure)

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

Dardani, C., Howe, L. J. M. S., Mukhopadhyay, N., Stergiakouli, E., Wren, Y. E., Humphries, K. J., Davies, A. J. V., Ho, K. M., Weinberg, S., Marazita, M., Mangold, E., Ludwig, K., Relton, C. L., Davey Smith, G., Lewis, S. J., Sandy, J. R., Davies, N. M. & Sharp, G. C., 6 May 2020, In : International Journal of Epidemiology. 12 p., dyaa047.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Downloads (Pure)

Combined effect of PNPLA3, TM6SF2, and HSD17B13 variants on risk of cirrhosis and hepatocellular carcinoma in the general population

Gellert-Kristensen, H., Richardson, T. G., Davey Smith, G., Nordestgaard, B. G., Tybjaerg-Hansen, A. & Stender, S., 19 Mar 2020, In : Hepatology. hep.31238.

Research output: Contribution to journalArticle (Academic Journal)

16 Downloads (Pure)

Commentary: Improving our statistical inferences requires meta-research

Thibault, R. T. & Munafò, M. R., 9 May 2020, In : International Journal of Epidemiology. 2 p., dyaa051.

Research output: Contribution to journalComment/debate (Academic Journal)

Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women

Lee, M., McMahon, G., Karhunen, V., Wade, K. H., Corbin, L. J., Hughes, D. A., Davey Smith, G., Lawlor, D. A., Jarvelin, M-R. & Timpson, N. J., 15 Jun 2020, In : Human Molecular Genetics. 29, 12, p. 9 2098 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Downloads (Pure)

Comparison of antihypertensive drug classes for dementia prevention

Walker, V., Davies, N. M., Martin, R. M. & Kehoe, P. G., 6 Jun 2020, (Accepted/In press) In : Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)