Organisation profile
Organisation profile
My research group investigates how the organism responds and adapts to stressful events.
Major research interests
- The signalling, epigenetic and genomic mechanisms in the brain underlying stress-related learning and memory processes.
- The regulation of the hypothalamic-pituitary-adrenal (HPA) axis under baseline and stress conditions.
- The physiological and neurobiological mechanisms underlying the beneficial effects of voluntary exercise on stress coping, HPA axis regulation, and anxiety-related and cognitive behaviour.
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Collaborations and top research areas from the last five years
Profiles
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Dr Karen R Mifsud
- Bristol Veterinary School - Lecturer in Behavioural Genetics / Epigenetics
- Neuro-Epigenetics of Stress and Cognition Research Group
- Bristol Neuroscience
Person: Academic , Member
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Emeritus Professor J M H M Reul
- Bristol Medical School (THS) - Emeritus Professor of Neuroscience
- Neuro-Epigenetics of Stress and Cognition Research Group
- Bristol Neuroscience
Person: Member, Group lead, Honorary and Visiting Academic
Research output
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Epigenetic Regulation of Hyaluronan-Associated Genes in the Brain: Identifying Key Regulatory Sites
Acevedo, R., Walton, E. & Mifsud, K. R., 1 May 2026, In: Epigenomes. 10, 2, 22 p., 28.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Non-steroidal Anti-inflammatory drugs (NSAIDs) as a hidden threat to scavenging raptors beyond Gyps: a call for wider research and surveillance
Colston, K., Mifsud, K. R., Rooney, N. J., Grande, J. M. & Bueno Padilla, I., 1 Oct 2025, In: Environmental Toxicology and Pharmacology. 119, 8 p., 104817.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain
Kennedy, C. L. M., Price, E. M., Mifsud, K. R., Salatino, S., Sharma, E., Engledow, S., Broxholme, J., Goss, H. M. & Reul, J. M. H. M., 7 Mar 2023, In: Neurobiology of Stress. 23, 100532.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access9 Citations (Scopus)
Projects
- 5 Finished
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Role of corticosteroid receptor DNA binding in stress-induced hippocampal gene transcription in relation to glucocorticoid and behavioural responses
Mifsud, K. R. (Co-Principal Investigator) & Reul, J. M. H. M. (Principal Investigator)
1/10/16 → 31/08/20
Project: Research
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Epigenetic control of gene transcriptional and behavioural responses to stress in the dentate gyrus
Reul, J. M. H. M. (Principal Investigator)
1/10/13 → 1/10/16
Project: Research
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A highly dynamic role of corticosteroid-binding globulin in the stress-induced glucocorticoid hormone response
Linthorst, A. C. E. (Principal Investigator) & Reul, J. M. H. M. (Co-Principal Investigator)
1/06/11 → 1/11/14
Project: Research
Student theses
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An investigation into the genomic actions of glucocorticoid binding receptors in the rat brain following acute stress and circadian influences
Kennedy, C. L. (Author), Reul, J. M. H. M. (Supervisor), 23 Jan 2020Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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Studies on epigenetic mechanisms and corticosteroid receptor action in the rat hippocampus
Price, E. (Author), Reul, J. M. H. M. (Supervisor) & Cordero Llana, O. (Supervisor), 25 Jan 2022Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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Unravelling a novel role for the mineralocorticoid receptor in dentate gyrus neurogenesis
Haque, S. N. (Author), Reul, J. M. H. M. (Supervisor), Cordero Llana, O. (Supervisor) & Mifsud, K. R. (Supervisor), 7 May 2024Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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