Research output per year
Research output per year
Research output
- 1 - 50 out of 3,924 results
Search results
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2024
4-Thiaproline accelerates the slow folding phase of proteins containing cis prolines in the native state by two orders of magnitude
Loughlin, J. O., Zinovjev, K., Napolitano, S., van der Kamp, M. & Rubini, M., 23 Jan 2024, In: Protein science : a publication of the Protein Society. 33, 2, 12 p., e4877.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1
Cross, J. A. A., Dawson, W. M., Shukla, S. R., Weijman, J. F. M. S., Mantell, J. M., Dodding, M. P. & Woolfson, D. N., Jul 2024, In: Nature Chemical Biology. 20, 7, p. 916-923 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
A framework for decolonising and diversifying biomedical sciences curricula: rediscovery, representation and readiness
Lu, T., Bashir, Z. I., Dalceggio, A., McKinnon, C. M., Miles, L., Mosley, A. S., Burton, B. R. & Robson, A., 2 Aug 2024, (E-pub ahead of print) In: FEBS Open Bio. 17 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Analysis of the GFP-labelled β-dystroglycan interactome in HEK-293 transfected cells reveals novel intracellular networks
Sciandra, F., Desiderio, C., Vincenzoni, F., Viscuso, S., Bozzi, M., Hubner, W., Jimenez-Gutierrez, G. E., Cisneros, B. & Brancaccio, A., 9 Apr 2024, In: Biochemical and Biophysical Research Communications. 703, 13 p., 149656.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)70 Downloads (Pure) -
An engineered baculoviral protein and DNA co-delivery system for CRISPR-based mammalian genome editing
Capin, J., Harrison, A., Raele, R. A., Yadav, S. K. N., Baiwir, D., Mazzucchelli, G., Quinton, L., Satchwell, T. J., Toye, A. M., Schaffitzel, C., Berger, I. & Aulicino, F., 12 Apr 2024, In: Nucleic Acids Research. 52, 6, p. 3450-3468 19 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus) -
An essential role for the RNA helicase DDX6 in NMDA receptor-dependent gene silencing and dendritic spine shrinkage
Perooli, F. M. M., Wilkinson, K. A., Pring, K. & Hanley, J. G., 6 Feb 2024, In: Scientific Reports. 14, 1, 17 p., 3066.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
Antibiotic Origami: Selective Formation of Spirotetronates in Abyssomicin Biosynthesis
Mbatha, S. Z., Back, C., Devine, A. J., Mulliner, H. M., Johns, S. T., Lewin, H., Cheung, K. A., Zorn, K., Stach, J. E. M., Hayes, M. A., Van der Kamp, M. W., Race, P. R. & Willis, C. L., 12 Aug 2024, (E-pub ahead of print) In: Chemical Science. 15, 34, p. 14009-14015 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils
Chu, J. Y., McCormick, B., Sundaram, K., Hardisty, G., Karmakar, U., Pumpe, C., Krull, E., Lucas, C. D., Amado-Azevedo, J., Hordijk, P. L., Caporali, A., Mellor, H., Baillie, J. K., Rossi, A. G. & Vermeren, S., 1 Jul 2024, In: Journal of Pathology. 263, 3, p. 347-359 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Assembling membraneless organelles from de novo designed proteins
Hilditch, A. T., Romanyuk, A., Cross, S. J., Obexer, R., McManus, J. J. & Woolfson, D. N., 1 Jan 2024, In: Nature Chemistry. 16, 1, p. 89-97 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access13 Citations (Scopus)56 Downloads (Pure) -
Assembly of Baculovirus Vectors for Multiplexed Prime Editing
Aulicino, F., Raele, R. A., Harrison, A. & Berger, I., 2 Jul 2024, Baculovirus: Methods and Protocols. Springer, p. 301-327 27 p. (Methods in Molecular Biology; vol. 2829).Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
1 Citation (Scopus) -
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
Yarmolinsky, J., Robinson, J. W., Mariosa, D., Karhunen, V., Huang, J., Dimou, N. L., Murphy, N., Burrows, K., Bouras, E., Smith-Byrne, K., Lewis, S. J., Galesloot, T. E., Kiemeney, L. A., Vermeulen, S., Martin, P. B., Albanes, D., Hou, L., Newcomb, P. A., White, E. & Wolk, A. & 21 others, , 31 Jan 2024, (E-pub ahead of print) In: EBioMedicine. 100, 21 p., 104991.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
Association of ABO and Rhesus blood groups with severe outcomes from non-SARS-CoV-2 respiratory infection: A prospective observational cohort study in Bristol, UK 2020–2022
Hathaway, A. R., Qian, G. Y., King, J. N., McGuinness, S., Maskell, N. A., Oliver, J. L., Finn, A. H. R., Danon, L., Challen, R. J., Toye, A. M., Hyams, C. & Avon CAP Research Group, 1 Mar 2024, In: British Journal of Haematology. 204, 3, p. 826-838 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Augmented gut hormone response to feeding in older adults exhibiting low appetite
Dagbasi, A., Warner, J., Catterall, V., Smith, K., Carroll, B. M., Crabtree, D. R., Frost, G. & Holliday, A., 1 Oct 2024, In: Appetite. 201, 11 p., 107415.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1
King, N. R., Martins Freire, C., Touhami, J., Sitbon, M., Toye, A. M. & Satchwell, T. J., 5 Feb 2024, (E-pub ahead of print) In: PLoS Pathogens. 20, 2, e1011989.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Biological resilience in health and disease
Weavers, H., 25 Jul 2024, In: Disease Models and Mechanisms. 17, 7, 9 p., dmm050799.Research output: Contribution to journal › Article (Academic Journal)
Open Access -
Building a super-resolution fluorescence cryomicroscope
Last, M. G. F., Voortman, L. M. & Sharp, T. H., 13 Mar 2024, (E-pub ahead of print) In: Methods in Cell Biology. p. 205-222 18 p.Research output: Contribution to journal › Article (Academic Journal)
Open AccessFile14 Downloads (Pure) -
Building tailor-made bioenergetic proteins and circuits from de novo redox proteins
Hardy, B. J., Bungay, E. L., Mellor, C., Curnow, P. & Anderson, J. L. R., 24 Jun 2024, In: Current Opinion in Electrochemistry. 46, 101541.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release
Velychko, T., Mohammad, E., Ferrer Vicens, I., Murphy, S., Cramer, P. & Lidschreiber, M., 30 May 2024, (E-pub ahead of print) In: Molecular Cell. 84, 12, p. 2287-2303.e10Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus) -
Cellular and molecular mechanisms of skin wound healing
Peña, O. A. & Martin, P., 25 Mar 2024, (E-pub ahead of print) In: Nature Reviews Molecular Cell Biology. 25, 8, p. 599-616 18 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
42 Citations (Scopus) -
CHC22 clathrin membrane recruitment uses SNX5 in bipartite interaction with secretory tether p115
Greig, J., Bates, G. T., Yin, D., Simonetti, B., Cullen , P. J. & Brodsky, F. M., 17 Jul 2024, bioRxiv.org.Research output: Working paper › Preprint
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CHC22 clathrin recruitment to the early secretory pathway requires two-site interaction with SNX5 and p115
Greig, J., Bates, G. T., Yin, D. I., Briant, K., Simonetti, B., Cullen , P. J. & Brodsky, F. M., 19 Aug 2024, (E-pub ahead of print) In: EMBO Journal. 43, 19, p. 4298-4323 26 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Complete absence of GLUT1 does not impair human terminal erythroid differentiation
Freire, C. M., King, N. R., Dzieciatkowska, M., Stephenson, D., Moura, P. L., Streekstra, G. J., D'Alessandro, A., Toye, A. M. & Satchwell, T., 25 Jan 2024, bioRxiv.org.Research output: Working paper › Preprint
File3 Downloads (Pure) -
Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint
Godivier, J., Lawrence, L., Wang, M., Hammond, C. & Nowlan, N. C., 8 Feb 2024, In: PLoS Computational Biology. 20, 2, 26 p., e1010940.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Computational design of de novo bioenergetic membrane proteins
Hardy, B. J. & Curnow, P., 1 Aug 2024, In: Biochemical Society Transactions. 52, 4, p. 1737–1745 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Cooperative Conformational Transitions Underpin the Activation Heat Capacity in the Temperature Dependence of Enzyme Catalysis
Walker, E. J., Hamill, C. J., Crean, R., Connolly, M. S., Warrender, A. K., Kraakman, K. L., Prentice, E. J., Steyn-Ross, A., Steyn-Ross, M., Pudney, C. R., Van der Kamp, M. W., Schipper, L. A., Mulholland, A. J. & Arcus, V. L., 5 Apr 2024, In: ACS Catalysis. 14, 7, p. 4379-4394 16 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
CryoET reveals actin filaments within platelet microtubules
Tsuji, C., Bradshaw, M., Allen, M. F., Jackson, M. L., Mantell, J. M., Borucu, U., Poole, A. W., Verkade, P., Hers, I., Paul, D. M. & Dodding, M. P., 16 Jul 2024, In: Nature Communications. 15, 1, 8 p., 5967 .Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Cyclic Ion Mobility for Hydrogen/Deuterium Exchange-Mass Spectrometry Applications
Griffiths, D., Anderson, M., Richardson, K., Inaba-Inoue, S., Allen, W. J., Collinson, I., Beis, K., Morris, M., Giles, K. & Politis, A., 16 Apr 2024, In: Analytical Chemistry. 96, 15, p. 5869-5877 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Decrypting allostery in membrane-bound K-Ras4B using complementary in silico approaches based on unbiased molecular dynamics simulations
Castelli, M., Marchetti, F., Osuna, S., Oliveira, A., Mulholland, A. J., Serapian, S. & Colombo, G., 10 Jan 2024, In: Journal of the American Chemical Society. 146, 1, p. 901-919 19 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access8 Citations (Scopus) -
Dedicated anticoagulation management protocols in fragility femoral fracture care – a source of significant variance and limited effectiveness in improving time to surgery: The hip and femoral fracture anticoagulation surgical timing evaluation (HASTE) study
On behalf of HASTE collaborators, Farhan-Alanie, M. M., Dixon, J., Irvine, S., Walker, R. & Eardley, W. G. P., Aug 2024, In: Injury. 55, 8, 111686.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Deep learning reveals a damage signalling hierarchy that coordinates different cell behaviours driving wound re-epithelialisation
Turley, J., Robertson, F., Chenchiah, I. V., Liverpool, T. B., Weavers, H. & Martin, P., 1 Sept 2024, In: Development (Cambridge). 151, 18, 11 p., dev202943.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype
Tilley, L. A., Karamatic Crew, V., Mankelow, T. J., AlSubhi, S. A., Jones, B., Borowski, A., Yahalom, V., Finkel, L., Singleton, B. K., Walser, P. J., Toye, A. M., Satchwell, T. J. & Thornton, N. M., 16 Aug 2024, (E-pub ahead of print) In: Blood. 2024025099.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile18 Downloads (Pure) -
Delineating redox cooperativity in water-soluble and membrane multiheme cytochromes through protein design
Hardy, B. J., Dubiel, P., Bungay, E. L., Rudin, M., Williams, C., Arthur, C. J., Guberman-Pfeffer, M. J., Sofia Oliveira, A., Curnow, P. & Anderson, J. L. R., 9 Jul 2024, In: Protein Science. 33, 8, e5113.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Delineation of the Complete Reaction Cycle of a Natural Diels-Alderase
Maschio, L., Back, C., Al Nawah, J., Bowen, J. I., Johns, S. T., Mbatha, S. Z., Han, L.-C., Lees, N. R., Zorn, K., Stach, J. E. M., Hayes, M., Van der Kamp, M. W., Pudney, C. R., Burston, S. G., Willis, C. L. & Race, P. R., 24 Jun 2024, (E-pub ahead of print) In: Chemical Science. 15, 29, p. 11572-11583 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
Design and Synthesis of DNA Origami Nanostructures to Control TNF Receptor Activation
Aba, G., Scheeren, F. A. & Sharp, T. H., 7 May 2024, Imaging Cell Signalling. Humana Press, p. 35-53 19 p. (Methods in Molecular Biology; vol. 2800).Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
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Detection of SARS-CoV-2-specific mucosal antibodies in saliva following concomitant COVID-19 and influenza vaccination in the ComFluCOV trial
Baum, H. E., Thirard, R. C. J., Halliday, A., Baos, S. C., Thomas, A., Harris, R. A., Oliver, E. H., Culliford, L., Hitchings, B. E., Todd, R. L., Gupta, K., Goenka, A., Finn, A. H. R., Rogers, C. A., Lazarus, R. & ComfluCOV Trial Group, 30 Apr 2024, In: Vaccine. 42, 12, p. 2945-2950 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)19 Downloads (Pure) -
Diversity and structure of the deep-sea sponge microbiome in the equatorial Atlantic Ocean
Williams, S. E., Varliero, G., Lurgi, M., Stach, J. E. M., Race, P. R. & Curnow, P., 29 Jul 2024, In: Microbiology. 170, 7, 001478.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
DNA binding and bridging by human CtIP in the healthy and diseased states
Lokanathan Balaji, S., De Bragança, S., Balaguer-Pérez, F., Northall, S., Wilkinson, O. J., Aicart-Ramos, C., Seetaloo, N., Sobott, F., Moreno-Herrero, F. & Dillingham, M. S., 26 Jun 2024, (E-pub ahead of print) In: Nucleic Acids Research. 52, 14, p. 8303-8319 17 p., gkae538.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation
Abendstein, L., Noteborn, W. E. M., Veenman, L. S., Dijkstra, D. J., van de Bovenkamp, F. S., Trouw, L. A. & Sharp, T. H., 15 May 2024, In: Journal of the American Chemical Society. 146, 19, p. 13455-13466 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the Sec translocon
Crossley, J. A., Allen, W. J., Watkins, D. W., Sabir, T., Radford, S. E., Tuma, R., Collinson, I. & Fessl, T., 2 Jan 2024, In: EMBO Journal. 43, 1, p. 1-13 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
Electric Fields Are a Key Determinant of Carbapenemase Activity in Class A β-Lactamases
Jabeen, H., Beer, M., Spencer, J., Van der Kamp, M. W., Bunzel, A. A. & Mulholland, A. J., 3 May 2024, In: ACS Catalysis. 14, 9, p. 7166-7172 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
emle-engine: A Flexible Electrostatic Machine Learning Embedding Package for Multiscale Molecular Dynamics Simulations
Zinovjev, K., Hedges, L. O., Montagud Andreu, R., Woods, C., Tuñón, I. & van der Kamp, M. W., 11 Jun 2024, In: Journal of Chemical Theory and Computation. 20, 11, p. 4514-4522 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation
Hamers, S. M. W. R., Boyle, A. L. & Sharp, T. H., 15 Jul 2024, In: Journal of Immunology. 213, 2, p. 235-243 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders
Buzas, D., Sun, H., Toelzer, C., Yadav, S. K. N., Borucu, U., Gautam, G., Gupta, K., Bufton, J. C., Capin, J. M., Sessions, R. B., Garzoni, F., Berger, I. & Berger-Schaffitzel, C. H., 9 Jan 2024, In: Structure. 32, 3, p. 342-351.e6Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution of a β-lactamase
Frohlich, C., Bunzel, A. A., Buda, K., Mulholland, A. J., Van der Kamp, M. W., Johnsen, P. J., Leiros, H.-K. S. & Tokuriki, N., 1 May 2024, In: Nature Catalysis. 7, 5, p. 499-509 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access5 Citations (Scopus) -
Erratum to: Comparing the two leading erythroid lines BEL-A and HUDEP-2
Daniels, D. E., Downes, D. J., Ferrer-Vicens, I., Ferguson, D. C. J., Singleton, B. K., Wilson, M. C., Trakarnsanga, K., Kurita, R., Nakamura, Y., Anstee, D. J. & Frayne, J., 1 Jan 2024, In: Haematologica. 109, 1, p. 364-364 1 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Exonic deletions in the MAL gene, encoding Myelin and Lymphocyte protein, define the rare inherited AnWj-negative phenotype: Exonic deletions in the MAL gene, encoding Myelin and Lymphocyte protein, define the rare inherited AnWj-negative phenotype
Alsubhi, S. A. O., 23 Jun 2024, p. 14. 1 p.Research output: Contribution to conference › Conference Paper
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Fluctuation relations to calculate protein redox potentials from molecular dynamics simulations
Oliveira, A. S. F., Rubio, J., Noble, C. E. M., Anderson, J. L. R., Anders, J. & Mulholland, A. J., 9 Jan 2024, In: Journal of Chemical Theory and Computation. 20, 1, p. 385-395 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)36 Downloads (Pure) -
Genome editing and kidney health
Tavakolidakhrabadi, N., Aulicino, F., May, C., Saleem, M., Berger, I. & Welsh, G. I., 17 Apr 2024, (E-pub ahead of print) In: Clinical Kidney Journal. 17, 5, 24 p., sfae119.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
Germline variant affecting p53β isoforms predisposes to familial cancer
Schubert, S. A., Ruano, D., Joruiz, S. M., Stroosma, J., Glavak, N., Montali, A., Pinto, L. M., Rodríguez-Girondo, M., Barge-Schaapveld, D. Q. C. M., Nielsen, M., van Nesselrooij, B. P. M., Mensenkamp, A. R., van Leerdam, M. E., Sharp, T. H., Morreau, H., Bourdon, J.-C., de Miranda, N. F. C. C. & van Wezel, T., 18 Sept 2024, In: Nature Communications. 15, 1, p. 8208 8208.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Gut microorganism enzymes unlock universal blood
Satchwell, T. J., Di Bartolo, N. & Toye, A. M., 29 Apr 2024, (E-pub ahead of print) In: Nature Microbiology. 9, 5, p. 1161–1162 2 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile56 Downloads (Pure)