School of Physiology, Pharmacology & Neuroscience

Projects

Projects per year 1900 2012 2014 2015 2016 2017 2018 2019 2022 2023 2024 2029

• 1 Not started
• 40 Active
• 227 Finished

Projects per year

Search results

• Finished

  Role of cardiac t-tubules in Ca regulation and arrhythmogenesis

  Bedford, A. M. (Principal Investigator)

  1/01/15 → 31/12/17

  Project: Research

  • Muscle Cell 100%
  • Caveolin 3 60%
  • Whole Cell 24%
  • Congestive Heart Failure 23%
  • Coronary Artery Ligation 21%

• Newton001: Temporal profiling of cardiac autonomic changes following organophosphorus poisoning

  Abdala Sheikh, A. P. (Co-Investigator) & Paton, J. F. R. (Principal Investigator)

  1/01/15 → 31/01/18

  Project: Research

  • Toxic Injury 100%
  • Organophosphate Insecticide 66%
  • Chlorpyrifos 66%
  • Chemoreceptor Reflex 45%
  • Methamidophos 33%

• Central Pattern Generator Implant to Improve Cardiac Function in Heart Failure

  Paton, J. F. R. (Principal Investigator)

  1/01/15 → 31/12/17

  Project: Research

  • Central Pattern Generator 100%
  • Respiratory Sinus Arrhythmia 100%
  • Cardiac Dysrhythmia 100%
  • Breathing 71%
  • Vagus Nerve 64%

• The role of microglia in synaptic plasticity in health and disease

  Collingridge, G. L. (Principal Investigator)

  1/11/14 → 31/10/16

  Project: Research

• IP3 receptor modulation of the atrioventricular node

  Hancox, J. C. (Principal Investigator)

  1/10/14 → 1/10/16

  Project: Research

  • Leporidae 100%
  • Muscle Cell 44%
  • Sodium Ion 42%
  • Sodium Current 28%
  • Action Potential 26%

• Probing a novel glutamatergic mechanism within baroreceptor terminals for controlling hypertension

  Paton, J. F. R. (Principal Investigator)

  1/10/14 → 30/09/17

  Project: Research

• PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse bladders - YR 1

  Drake, M. J. (Principal Investigator)

  1/10/14 → 30/09/15

  Project: Research, Parent

  • Spinal Cord Transsection 100%
  • Interstitial Cell 100%
  • Phosphodiesterase V 100%
  • Bladder 100%
  • Acrolein 75%

• Understanding vagal control of the fourth ventricle

  Kasparov, S.

  1/09/14 → 30/11/19

  Project: Research

• IRSF Advanced Neuro-therapeutic Grant of Excellence Award: Novel highly selective and potent serotonergic 1a receptor agonist for the treatment of Rett Syndrome in murine models: a pre-clinical study

  Abdala Sheikh, A. P. (Co-Principal Investigator) & Paton, J. F. R. (Co-Principal Investigator)

  1/08/14 → 31/07/16

  Project: Research

  • Rett Syndrome 100%
  • Methyl CpG Binding Protein 2 66%
  • Synaptic Inhibition 50%
  • Astrocyte 50%
  • Gamma-Aminobutyric Acid 28%

• Exploring astrocytic orphan G-protein coupled receptors as potential targets for neuroprotective therapies

  Kasparov, S. (Principal Investigator)

  15/07/14 → 14/07/17

  Project: Research

  • Astrocyte 100%
  • Receptor 64%
  • Functional Magnetic Resonance Imaging 35%
  • Neuroprotection 35%
  • Neuroprotective Agent 33%

• Midbrain dopamine systems and control of bladder function

  Lovick, T. A. (Principal Investigator)

  9/06/14 → 8/12/17

  Project: Research

• The neurobiology of cognitive affective biases in depression and their role in antidepressant therapy

  Robinson, E. S. J. (Principal Investigator)

  2/06/14 → 1/09/17

  Project: Research

  • Antidepressant 100%
  • Corticosterone 72%
  • Major Depressive Disorder 71%
  • Emotion 67%
  • Decision-Making 58%

• Prof Will Wood: 'Modelling of wound repair and inflammation in the Drosophila embryo'

  Martin, P. B. (Principal Investigator) & Cross, R. H. (Principal Investigator)

  1/04/14 → 30/06/18

  Project: Research

  • Adipocyte 100%
  • Cell Migration 100%
  • Cell Body 100%
  • Cell Lineage 66%
  • Liquid 33%

• Understanding the hippocampal-perirhinal-prefontal tripartite circuit in associative memory

  Bashir, Z. I. (Principal Investigator)

  31/03/14 → 29/06/17

  Project: Research

  • Prefrontal Cortex 100%
  • Synaptic Transmission 72%
  • Hippocampus 63%
  • NMDA Receptor 54%
  • Episodic Memory 36%

• Identifying the role of NMDA receptors in STP through investigation of synaptic plasticity and discovery of novel subtype-specific antagonists

  Jane, D. E. (Principal Investigator)

  28/02/14 → 30/07/17

  Project: Research

  • Receptor 100%
  • Long-Term Potentiation 68%
  • Dextro Aspartic Acid 60%
  • NMDA Receptor 51%
  • Synaptic Plasticity 37%

• Investigating the role of neuropsychological processes in stress induced negative affective states and associated behaviour

  Robinson, E. S. J. (Principal Investigator)

  1/02/14 → 1/02/16

  Project: Research

  • Major Depressive Disorder 100%
  • Antidepressant 89%
  • Mood Disorder 71%
  • Immunomodulating Drugs 71%
  • Carbamazepine 71%

• Biomechanical characterisation of joints in osteoarthritis mutant zebrafish; studying interactions between genotype and biomechanics in osteoarthritis

  Hammond, C. L. (Principal Investigator)

  3/01/14 → 2/07/17

  Project: Research

  • Bone Development 100%
  • Cell Function 100%
  • Zebra Fish 100%
  • Rigidity 50%
  • Heterozygote 50%

• Biomechanical characterisation of joints in osteoarthritis mutant zebrafish; studying interactions between genotype and biomechanics in osteoarthritis

  Hammond, C. L. (Principal Investigator)

  3/01/14 → 2/07/17

  Project: Research

  • Cell Function 100%
  • Morphogenesis 83%
  • Muscle Contraction 57%
  • Finite Element Analysis 57%
  • Muscle Strain 50%

• Statistical modelling of in vivo immune response dynamics in zebrafish to multiple stimuli

  Martin, P. B. (Principal Investigator)

  11/11/13 → 11/11/16

  Project: Research

  • Immunocompetent Cell 100%
  • Inflammation Response 60%
  • Wound Healing 54%
  • Innate Immune System 45%
  • Innate Immunity 45%

• Role of the JAK-STAT pathway in LTD

  Collingridge, G. L. (Principal Investigator)

  1/09/13 → 1/01/17

  Project: Research

  • AMPA Receptor 100%
  • Synapse 64%
  • Hippocampus 62%
  • Metabotropic Glutamate Receptor 60%
  • Metabotropic Receptor 60%

• Molecular mechanisms of long-term Depression int the hippocampus

  Collingridge, G. L. (Principal Investigator)

  1/05/13 → 30/04/18

  Project: Research

  • Long-Term Potentiation 100%
  • Synaptic Plasticity 86%
  • Hippocampus 86%
  • NMDA Receptor 79%
  • Long-Term Depression 70%

• Regulation of VEGF Splicing Ref: BB/J007293/2 (University of Nottingham lead - Prof David Bates)

  Oltean, S.

  8/04/13 → 8/08/15

  Project: Research

• Role for glia-neuron interaction in the brain ageing and longevity (via University of Warwick)

  Kasparov, S. (Principal Investigator)

  1/04/13 → 1/04/16

  Project: Research

• Developing new mature, functional vascular networks in ischemic disease

  Bates, D. O. (Principal Investigator)

  1/04/13 → 1/04/16

  Project: Research

• Development of biotin-tagged affinity ligands and fluorophore-conjugated probes for the study of native kainate receptors

  Molnar, E. (Principal Investigator)

  1/03/13 → 1/03/16

  Project: Research

  • Glutamate Receptor 100%
  • Synapse 70%
  • Glutamic Acid 57%
  • Single-Nucleotide Polymorphism 55%
  • Promoter Region 46%

• Template neuronal networks in developing neocortex

  Ashby, M. C. (Principal Investigator)

  3/01/13 → 3/05/16

  Project: Research

  • Synapse 100%
  • Synaptic Plasticity 66%
  • Glutamate Receptor 66%
  • NMDA Receptor 66%
  • Tauopathy 66%

• A Mathematical Modelling approach to defining factors which influence keel fractures in free range laying hens

  Toscano, M. J. (Co-Principal Investigator), Tsaneva-Atanasova, K. T. (Researcher) & Tarlton, J. F. (Principal Investigator)

  1/01/13 → 31/12/16

  Project: Research

  • Laying Hens 100%
  • Keel Bone 87%
  • Ex Vivo 50%
  • Hen 41%
  • Egg Production 37%

• How does light control the activity and electrical properties of neurons integrating arousal behaviour, circadian rhythms, and sleep?

  Hodge, J. J. L. (Principal Investigator)

  1/01/13 → 1/04/16

  Project: Research

  • Circadian Rhythm 100%
  • CASK 87%
  • Mushroom Body 67%
  • Memory Disorder 65%
  • Autophosphorylation 60%

• Regulation of spine Ca2+ dynamics and spike timing-dependent synaptic plasticity by muscarinic acetylcholine receptors

  Mellor, J. R. (Principal Investigator)

  1/10/12 → 1/10/15

  Project: Research

  • Synaptic Plasticity 100%
  • Hippocampus 71%
  • Long-Term Potentiation 51%
  • NMDA Receptor 40%
  • Place Cell 39%

• A dual role for the Golgi matrix protein giantin in extracellular matrix secretion and cilia function

  Bergen, D. J. M. (Student), Stephens, D. J. (Principal Investigator) & Hammond, C. L. (Co-Investigator)

  1/10/12 → 14/11/17

  Project: Research

  • Cilium 100%
  • Zebra Fish 72%
  • Matrix Protein 71%
  • GALNT3 42%
  • Extracellular Matrix 40%

• MRC Centenary Award (Supplement to Centre Grant G0601841)

  Collingridge, G. L. (Principal Investigator)

  1/08/12 → 1/10/13

  Project: Research

  • Knockout Mouse 100%
  • Dextro Aspartic Acid 100%
  • N Methyl Dextro Aspartic Acid Receptor 100%
  • Receptor 100%
  • Long Term Potentiation 100%

• Hypothalmic glucose-sensitive transcriptomes

  Balthasar, N. (Principal Investigator)

  16/07/12 → 16/07/15

  Project: Research

  • Dorsal Root 100%
  • Ganglion 100%
  • Somatic Cell 100%
  • Renilla 100%
  • Cell Membrane 100%

• Dissection of the cellular mechanisms of functional MRI using targeted optogenetics

  Kasparov, S. (Principal Investigator)

  1/07/12 → 1/10/15

  Project: Research

  • Astrocyte 100%
  • Functional Magnetic Resonance Imaging 97%
  • Optogenetics 71%
  • Locus Coeruleus 48%
  • Norepinephrine 48%

• How does ethanol reverse opioid tolerance?

  Henderson, G. (Principal Investigator)

  1/06/12 → 1/06/15

  Project: Research

  • Opiate 100%
  • Morphine 74%
  • Receptor 50%
  • Opiate Receptor 45%
  • Internalization 34%

• Altered intrinsic excitability in transgenic mouse models of progressive beta-amyloidopathy

  Randall, A. D. (Principal Investigator)

  12/04/12 → 12/04/15

  Project: Research

• Regulation of Membrane Trafficking and Signalling by Clathrin Light Chain Phosphorylation

  Mundell, S. J.

  1/04/12 → 1/01/16

  Project: Research

• In vivo regulation of angiogenesis by VEGF splicing (resubmit)

  Bates, D. O. (Principal Investigator)

  1/04/12 → 1/04/15

  Project: Research

• Do biased agonists at the mu-opioid receptor induce different patterns of receptor phosphorylation?

  Kelly, E. P. (Principal Investigator)

  1/03/12 → 1/03/15

  Project: Research

  • Opiate Receptor 100%
  • Opiate 94%
  • Receptor 88%
  • Morphine 72%
  • Opioid Receptor 60%

• Cerebellar complex spikes: activity patterns, behaviour and adaptation

  Apps, R. (Principal Investigator)

  1/02/12 → 31/07/17

  Project: Research

  • Purkinje Cell 100%
  • Cerebellum 71%
  • Climbing Fiber 69%
  • Cerebellar Cortex 67%
  • Behavior (Neuroscience) 30%

• Development of a novel clinical platelet analyser

  Day, J. C. C. (Co-Principal Investigator), Poole, A. W. (Co-Principal Investigator) & Ascione, R. (Co-Principal Investigator)

  1/01/12 → 1/01/13

  Project: Research

  • Platelet 100%
  • Bleeding 100%
  • Antiplatelet 100%
  • Thrombocyte Aggregation 66%
  • Thrombocyte Function 66%

• Carotid body ablation to treat sympathetic-overactivity: pre-clinical and clinical studies

  Abdala Sheikh, A. P. (Co-Investigator) & Paton, J. F. R. (Principal Investigator)

  1/01/12 → 31/01/14

  Project: Research

  • Carotid Body 100%
  • Denervation 66%
  • Carotid Sinus 58%
  • Purinergic P2X3 Receptor 33%
  • Purinergic Receptor 33%

• Manipulation of Vascular Endothelial Growth Factor isoform-repertoire as a therapeutic strategy in chronic kidney disease

  Bates, D. O. (Principal Investigator)

  10/10/11 → 10/10/14

  Project: Research

• Schizophrenia gene

  Jones, M. W. (Principal Investigator)

  1/07/11 → 1/01/15

  Project: Research

• Delineating the neural basis of sequence memory in the rat

  Warburton, E. (Principal Investigator)

  4/04/11 → 4/04/14

  Project: Research

  • Recognition Memory 100%
  • Prefrontal Cortex 53%
  • Perirhinal Cortex 52%
  • Hippocampus 34%
  • Episodic Memory 24%

• SNCF: Control of cognitve networks

  Jones, M. W. (Principal Investigator)

  1/04/11 → 1/10/16

  Project: Research

  • Hippocampus 100%
  • Prefrontal Cortex 83%
  • Neurophysiology 74%
  • Sleep Spindle 72%
  • Behavior (Neuroscience) 69%

• BBSRC - link account to BIOC RA0514 (BB/H014284/1): 'Regulation of Arp2/3-mediated actin polymerisation by PICK1 in neuronal function'.

  Mellor, J. R. (Principal Investigator)

  10/01/11 → 10/01/14

  Project: Research

  • N Methyl Dextro Aspartic Acid Receptor 100%
  • AMPA Receptor 89%
  • Synaptic Plasticity 79%
  • Nerve Cell Plasticity 79%
  • Actin 79%

• Regulation of platelet purinergic receptor function by NHERF proteins

  Mundell, S. J. (Principal Investigator)

  1/06/10 → 1/06/13

  Project: Research

• The signalling pathways involved in NMDAR-dependent LTD

  Collingridge, G. L. (Principal Investigator)

  3/05/10 → 3/09/13

  Project: Research

• Human hypertension and cerebral artery stenosis

  Paton, J. F. R. (Principal Investigator)

  1/05/10 → 1/07/12

  Project: Research

• The neurophysiological basis of response inhibition and its use in diagnosis of complex frontal cortical dysfunction

  Jones, M. W. (Principal Investigator)

  1/02/10 → 1/02/11

  Project: Research