Organization profile

Organisation profile

Head of Research for this group: Professor Stafford Lightman

Regulation of the hypothalamo-pituitary-adrenal (HPA) axis in health and disease

Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.

We are studying the mechanisms through which the brain recognises environmental stress and disease, and the pathways it uses to initiate appropriate responses in physiological regulation and gene transcription. We have been particularly interested in the way the body utilises rhythmic activation of neuroendocrine response systems such as the hypothalamo-pituitary-adrenal axis to provide digital as well as analogue signals to glucocorticoid responsive tissues throughout the body.

In my clinical studies, we are developing novel ways of administrating glucocorticoid replacement to patients with adrenal insufficiency and have been developing systems to assess stress responses in disease and in patients undergoing surgery.

Fingerprint Dive into the research topics where Systems Neuroendocrinology Research Group is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

    Pooley, J., Rivers, C. A., Kilcooley, M., Paul, S. N., Cavga, A. D., Kershaw, Y. M., Muratcioglu, S., Gursoy, A., Keskin, O. & Lightman, S. L., 10 Jan 2020, In : PLoS ONE. 15, 1, 35 p., e0227520.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 56 Downloads (Pure)

    Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery

    Gibbison, B., Keenan, D. M., Roelfsema, F., Evans, J., Phillips, K., Rogers, C. A., Angelini, G. D. & Lightman, S. L., 1 May 2020, In : The Journal of clinical endocrinology and metabolism. 105, 5, dgz206.

    Research output: Contribution to journalArticle (Academic Journal)

  • Dynamics of ACTH and cortisol secretion and implications for disease

    Lightman, S. L., Birnie, M. T. & Conway-Campbell, B. L., 1 Jun 2020, In : Endocrine Reviews. 41, 3, p. 470–490 21 p., bnaa002.

    Research output: Contribution to journalReview article (Academic Journal)

    Open Access
    File
  • 11 Downloads (Pure)

    Projects

    Student theses

    Characterization of dissociative anesthetics acting at the NMDA receptor site

    Author: Kang, H. H., 19 Mar 2019

    Supervisor: Lightman, S. (Supervisor) & Collingridge, G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Free cortisol in healthy individuals - combining microdialysis and a novel portable collection device for continuous ambulatory sampling

    Author: Bhake, R., 10 May 2016

    Supervisor: Lightman, S. L. (Supervisor) & Linthorst, A. C. E. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Prizes

    Best Basic Science Abstract (Society for Endocrinology BES Meeting 2015)

    Pooley, John R (Recipient), 4 Nov 2015

    Prize: Prizes, Medals, Awards and Grants

  • High Commended Oral Presentation (Society for Endocrinology BES Meeting 2015)

    Pooley, John R (Recipient), 4 Nov 2015

    Prize: Prizes, Medals, Awards and Grants

  • Neuroendocrine Research Award Medal

    Lightman, Stafford L (Recipient), 26 Apr 2014

    Prize: Prizes, Medals, Awards and Grants

    Activities

    • 15 Participation in conference
    • 7 Participation in workshop, seminar, course
    • 1 Fellowship awarded competitively

    International Congress of Neuroendocrinology

    Stafford L Lightman (Invited speaker)

    17 Aug 201420 Aug 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Annual Meeting of European Neuroendocrine Association

    Stafford L Lightman (Invited speaker)

    10 Sep 201413 Sep 2014

    Activity: Participating in or organising an event typesParticipation in conference

    International Society for Psychoneuroendocrinology Interactive Symposium Pre-Conference Day - Stress, Rhythm and Blues

    Stafford L Lightman (Invited speaker)

    20 Aug 2013

    Activity: Participating in or organising an event typesParticipation in conference