Research output per year
Research output per year
BS2 8DZ
United Kingdom
Head of Research for this group: Professor Stafford Lightman
Regulation of the hypothalamo-pituitary-adrenal (HPA) axis in health and disease
Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.
We are studying the mechanisms through which the brain recognises environmental stress and disease, and the pathways it uses to initiate appropriate responses in physiological regulation and gene transcription. We have been particularly interested in the way the body utilises rhythmic activation of neuroendocrine response systems such as the hypothalamo-pituitary-adrenal axis to provide digital as well as analogue signals to glucocorticoid responsive tissues throughout the body.
In my clinical studies, we are developing novel ways of administrating glucocorticoid replacement to patients with adrenal insufficiency and have been developing systems to assess stress responses in disease and in patients undergoing surgery.
Person: Academic , Member, Group lead
Person: Academic , Member
Person: Member, Honorary and Visiting Academic
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Lightman, S. L. (Principal Investigator), Russell, G. M. (Co-Investigator), Bradley, K. J. (Co-Investigator), Kalafatakis, K. (Co-Investigator), Durant, C. F. (Co-Investigator), Simunkova, K. (Co-Investigator), Johnson, A. (Co-Investigator), Munafo, M. R. (Co-Investigator), Harmer, C. J. (Co-Investigator), Davey Smith, G. (Co-Investigator), Timpson, N. J. (Co-Investigator) & Sutton, E. J. (Co-Investigator)
1/01/15 → …
Project: Research
Russell, G. M. (Principal Investigator)
2/05/16 → 30/09/20
Project: Research
Lightman, S. L. (Principal Investigator)
30/06/13 → 29/06/18
Project: Research
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
Pooley, J. (Recipient), 4 Nov 2015
Prize: Prizes, Medals, Awards and Grants
Lightman, S. L. (Recipient), 2013
Prize: Prizes, Medals, Awards and Grants
Upton, T. (Creator), Zavala, E. (Creator), Methlie, P. (Creator), Kämpe, O. (Creator), Tsagarakis, S. (Creator), Øksnes, M. (Creator), Bensing, S. (Creator), Vassiliadi, D. (Creator), Grytaas, M. (Creator), Botusan, I. (Creator), Ueland, G. (Creator), Berinder, K. (Creator), Simunkova, K. (Creator), Balomenaki, M. (Creator), Margaritopoulos, D. (Creator), Henne, N. (Creator), Crossley, R. (Creator), Russell, G. M. (Creator), Husebye, E. (Creator), Lightman, S. L. (Creator) & Upton, T. J. (Contributor), DataverseNO, 21 Jun 2023
DOI: 10.18710/5tw8yf/oihxu2, https://dataverse.no/file.xhtml?persistentId=doi:10.18710/5TW8YF/OIHXU2
Dataset
Upton, T. (Creator), Zavala, E. (Creator), Methlie, P. (Creator), Kämpe, O. (Creator), Tsagarakis, S. (Creator), Øksnes, M. (Creator), Bensing, S. (Creator), Vassiliadi, D. (Creator), Grytaas, M. (Creator), Botusan, I. (Creator), Ueland, G. (Creator), Berinder, K. (Creator), Simunkova, K. (Creator), Balomenaki, M. (Creator), Margaritopoulos, D. (Creator), Henne, N. (Creator), Crossley, R. (Creator), Russell, G. M. (Creator), Husebye, E. (Creator), Lightman, S. L. (Creator) & Upton, T. J. (Contributor), DataverseNO, 21 Jun 2023
DOI: 10.18710/5tw8yf/x9axnp, https://dataverse.no/file.xhtml?persistentId=doi:10.18710/5TW8YF/X9AXNP
Dataset
Upton, T. (Creator), Zavala, E. (Creator), Methlie, P. (Creator), Kämpe, O. (Creator), Tsagarakis, S. (Creator), Øksnes, M. (Creator), Bensing, S. (Creator), Vassiliadi, D. (Creator), Grytaas, M. (Creator), Botusan, I. (Creator), Ueland, G. (Creator), Berinder, K. (Creator), Simunkova, K. (Creator), Balomenaki, M. (Creator), Margaritopoulos, D. (Creator), Henne, N. (Creator), Crossley, R. (Creator), Russell, G. M. (Creator), Husebye, E. (Creator), Lightman, S. L. (Creator) & Upton, T. J. (Contributor), DataverseNO, 21 Jun 2023
DOI: 10.18710/5tw8yf/sg4n75, https://dataverse.no/file.xhtml?persistentId=doi:10.18710/5TW8YF/SG4N75
Dataset
Lightman, S. L. (Invited speaker)
Activity: Participating in or organising an event types › Participation in conference
Lightman, S. L. (Invited speaker)
Activity: Participating in or organising an event types › Participation in conference
Lightman, S. L. (Invited speaker)
Activity: Participating in or organising an event types › Participation in workshop, seminar, course