Dr Abdelkader Essafi

BSc(Lond.), PhD(Lond.)

  • BS8 1TD

20042019

Research output per year

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Research Output

  • 15 Article (Academic Journal)
2017

Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

Peluso, S., Douglas, A., Hill, A., De Angelis, C., Moore, B. L., Grimes, G., Petrovich, G., Essafi, A. & Hill, R. E., 27 Oct 2017, In : eLife. 6, 22 p., e28590.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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238 Downloads (Pure)
2013

Mutations in HNF1A result in marked alterations of plasma glycan profile

Thanabalasingham, G., Huffman, J. E., Kattla, J. J., Novokmet, M., Rudan, I., Gloyn, A. L., Hayward, C., Adamczyk, B., Reynolds, R. M., Muzinic, A., Hassanali, N., Pucic, M., Bennett, A. J., Essafi, A., Polasek, O., Mughal, S. A., Redzic, I., Primorac, D., Zgaga, L., Kolcic, I. & 20 others, Hansen, T., Gasperikova, D., Tjora, E., Strachan, M. W. J., Nielsen, T., Stanik, J., Klimes, I., Pedersen, O. B., Njølstad, P. R., Wild, S. H., Gyllensten, U., Gornik, O., Wilson, J. F., Hastie, N. D., Campbell, H., McCarthy, M. I., Rudd, P. M., Owen, K. R., Lauc, G. & Wright, A. F., Apr 2013, In : Diabetes. 62, 4, p. 1329-37 9 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)
2012

Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly

Lettice, L. A., Williamson, I., Wiltshire, J. H., Peluso, S., Devenney, P. S., Hill, A. E., Essafi, A., Hagman, J., Mort, R., Grimes, G., DeAngelis, C. L. & Hill, R. E., 14 Feb 2012, In : Developmental Cell. 22, 2, p. 459-467 9 p.

Research output: Contribution to journalArticle (Academic Journal)

88 Citations (Scopus)
2011

A Wt1-controlled chromatin switching mechanism underpins tissue-specific Wnt4 activation and repression

Essafi, A., Webb, A., Berry, RL., Slight, J., Burn, SF., Spraggon, L., Velecela, V., Martinez-Estrada, OM., Wiltshire, JH., Roberts, SGE., Brownstein, D., Davies, JA., Hastie, ND. & Hohenstein, P., 25 Aug 2011, In : Developmental Cell. 21, 3, p. 559 - 574

Research output: Contribution to journalArticle (Academic Journal)

101 Citations (Scopus)
2010

Genomics meets glycomics—The first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation

Lauc, G., Essafi, A., Huffman, J. E., Hayward, C., Knežević, A., Kattla, J. J., Polašek, O., Gornik, O., Vitart, V., Abrahams, J. L., Pučić, M., Novokmet, M., Redžić, I., Campbell, S., Wild, S. H., Borovečki, F., Wang, W., Kolčić, I., Zgaga, L., Gyllensten, U. & 6 others, Wilson, J. F., Wright, A. F., Hastie, N. D., Campbell, H., Rudd, P. M. & Rudan, I., 23 Dec 2010, In : PLoS Genetics. 6, 12, e1001256.

Research output: Contribution to journalArticle (Academic Journal)

138 Citations (Scopus)

Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin

Martínez-Estrada, O. M., Lettice, L. A., Essafi, A., Guadix, J. A., Slight, J., Velecela, V., Hall, E., Reichmann, J., Devenney, P. S., Hohenstein, P., Hosen, N., Hill, R. E., Muñoz-Chapuli, R. & Hastie, N. D., Jan 2010, In : Nature Genetics. 42, 1, p. 89-93 5 p.

Research output: Contribution to journalArticle (Academic Journal)

236 Citations (Scopus)

WT1 the oncogene: a tale of death and HtrA

Essafi, A. & Hastie, N. D., 29 Jan 2010, In : Molecular Cell. 37, 2, p. 153-5 3 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)
2009

Highly conserved non-coding elements on either side of the SOX9 associated with Pierre Robin sequence

Benko, S., Fantes, J., Amiel, J., Dirk Keinjan, D-J., Thomas, S., Ramsey, J., Jamshidi, N., Essafi, A., Heaney, S., Gordon, CT., McBride, D., Golzio, C., Fisher, M., Perry, P., Abadie, V., Ayuso, C., Holder-Espinasse, M., Kilpatrick, NM., Lees, MM., Picard, A. & 12 others, Temple, IK., Thomas, P., Vazquez, M-P., Vekemans, M., Roest Crollius, H., Hastie, ND., Munnich, A., Etchevers, H., Pelet, A., Farlie, P., Fitzpatrick, D. & Lyonnet, S., Mar 2009, In : Nature Genetics. 41, 3, p. 359 - 364 6 p.

Research output: Contribution to journalArticle (Academic Journal)

249 Citations (Scopus)

Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt

Essafi, A., Gomes, A. R., Pomeranz, K. M., Zwolinska, A. K., Varshochi, R., McGovern, U. B. & Lam, E. W-F., 2009, In : Methods in Molecular Biology. 462, p. 201-11 11 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)
2007

FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1

Birkenkamp, K. U., Essafi, A., van der Vos, K. E., da Costa, M., Hui, R. C-Y., Holstege, F., Koenderman, L., Lam, E. W-F. & Coffer, P. J., 26 Jan 2007, In : Journal of Biological Chemistry. 282, 4, p. 2211-20 10 p.

Research output: Contribution to journalArticle (Academic Journal)

68 Citations (Scopus)

Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression

Delpuech, O., Griffiths, B., East, P., Essafi, A., Lam, E. W-F., Burgering, B., Downward, J. & Schulze, A., Jul 2007, In : Molecular and Cellular Biology. 27, 13, p. 4917-30 14 p.

Research output: Contribution to journalArticle (Academic Journal)

130 Citations (Scopus)
2006

Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A

Shore, A. M., White, P. C., Hui, R. C-Y., Essafi, A., Lam, E. W-F., Rowe, M. & Brennan, P., Nov 2006, In : Journal of Virology. 80, 22, p. 11191-9 9 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium

Labied, S., Kajihara, T., Madureira, P. A., Fusi, L., Jones, M. C., Higham, J. M., Varshochi, R., Francis, J. M., Zoumpoulidou, G., Essafi, A., Fernandez de Mattos, S., Lam, E. W-F. & Brosens, J. J., Jan 2006, In : Molecular Endocrinology. 20, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle (Academic Journal)

106 Citations (Scopus)
2005

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells

Essafi, A., Fernández de Mattos, S., Hassen, Y. A. M., Soeiro, I., Mufti, G. J., Thomas, N. S. B., Medema, R. H. & Lam, E. W-F., 31 Mar 2005, In : Oncogene. 24, 14, p. 2317-29 13 p.

Research output: Contribution to journalArticle (Academic Journal)

236 Citations (Scopus)
2004

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism

Fernández de Mattos, S., Essafi, A., Soeiro, I., Pietersen, A. M., Birkenkamp, K. U., Edwards, C. S., Martino, A., Nelson, B. H., Francis, J. M., Jones, M. C., Brosens, J. J., Coffer, P. J. & Lam, E. W-F., Nov 2004, In : Molecular and Cellular Biology. 24, 22, p. 10058-71 14 p.

Research output: Contribution to journalArticle (Academic Journal)

136 Citations (Scopus)