Projects per year
Neo-adjuvant therapy response in locally advanced rectal cancer
BCL-3 and NF-κB signalling
Young-onset colorectal cancer
Colorectal cancer is the third most common cause of cancer related mortality in the UK. More advanced disease often requires additional therapy to control it and acheive optimal rates of cure. What is particularly concerning is that rates of younger onset cancer (diagnosis under 50 years old) are increasing quickly, with no clear cause. These patients more commonly present with advanced disease. In rectal cancers, pre-operative therapy with DNA damaging agents such as platinum-based chemotherapy and radiotherapy are commonly used in patients with more advanced disease.
We have an academic interest in three principal aspects of locally advanced rectal cancer.
BCL-3 and NF-κB signalling in DNA damaging therapy response
Firstly, we want to understand how the pro-inflammatory signalling pathway NF-κB regulates therapy response using in-vitro 2D and 3D models of colorectal cancer. We are particularly focused on a protein called BCL-3, which is known to act as a co-regulatory protein in the NF-κB signalling pathway, and how it regulates the DNA damage response in colorectal cancer cells.
The rising incidence of young-onset colorectal cancer
Secondly, with collaboration with consultant clinical colleagues (Mr David Messenger and Mr Michael Thomas Consultant Colorectal Surgeons) at University Hospitals Bristol and Weston we aim to determine the demographic changes in colorectal cancer incidence over time and use this to generate hypotheses and inform our in-vitro research. This work has shown significant increases in the age-specific incidence of colorectal cancer from around 2006 onwards. The increase is particularly observed in distal tumours (tumours arising in the sigmoid, recto-sigmoid or rectum) with no apparent differences seen between genders, socioeconomic status or ethnicity. Tumours in this age group are far more likely to present with advanced disease (advanced T-stage, nodal disease or metastasis). Future work aims to define differences in management of these patients between older and younger onset patients, in collaboration with Leeds, Oxford and Liverpool.
Sequencing of circulating tumour DNA in Rectal cancer - SectR
Finally, we aim to better measure the response of locally advanced rectal cancers to neo-adjuvant therapy. Despite improvements in imaging and clinical assessment, determining whether patients have undergone a complete or incomplete response to therapy is challenging. We aim to utilise circulating tumour DNA to better define therapy response and enable more personalised treatment decisions to be made for each patient.
Award Date: 1 Jul 2019
Award Date: 10 Jul 2014
Royal College of Surgeons of Edinburgh
Award Date: 12 Jul 2012
Peninsula College of Medicine and Dentistry
Award Date: 9 Jul 2009
- Colorectal cancer
- Therapy response
- Early-onset colorectal cancer
- 1 Finished
Does Aspirin increase the clinical response to pre-operative chemo-radiotherapy (CRT) in rectal cancer?
2/08/15 → 1/08/18
Parker, C., Chambers, A. C., Flanagan, D. J., Ho, J. W. Y., Collard, T. J., Ngo, G., Baird, D. M., Timms, P., Morgan, R. G., Sansom, O. J. & Williams, A. C., 1 Jul 2022, In: DNA repair. 115, 11 p., 103331.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Downloads (Pure)
Demographic trends in the incidence of malignant appendiceal tumours in England between 1995 and 2016: Population-based analysisOrchard, P., Preece, R., Thomas, M. G., Dixon, S. W., Wong, N. A. C. S., Chambers, A. C. & Messenger, D. E., 27 Aug 2022, In: BJS Open. 6, 4, zrac103.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile1 Downloads (Pure)
5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: implications for chemoprophylaxis in colorectal tumorigenesisDixon, S. W., Collard, T. J., Mortensson, E. M. H., Legge, D. N., Chambers, A. C., Greenhough, A., Creed, T. J. & Williams, A. C., 8 Jun 2021, In: British Journal of Cancer. 124, 12, p. 1959-1969 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Citations (Scopus)57 Downloads (Pure)
- 2 Fellowship awarded competitively
Chambers, A. C., 19 Mar 2019
Supervisor: Williams, A. C. (Supervisor) & Brown, K. W. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)File