Snapshot

Our lab investigates the post-translational control of plasma membrane protein signalling and turnover in neurons. For more details, please check our lab website. Follow Adam on Twitter: @adam_grieve.

General Summary

The function of signalling receptors, transporters and channels in the plasma membrane is essential for all living cells. Their biological importance is highlighted by the observation that ~70% of clinical drugs target integral membrane proteins and that even subtle mutations or defects in their activity lead to human disease. 

The major goal of our group is to define the molecular mechanisms for integral membrane protein regulation within the plasma membrane. In particular, we focus on relatively unexplored regulators – such as intramembrane proteases – that have the ability to “read” and respond to the dynamics of transmembrane domains of receptors, channels and transporters.

We anticipate that our study of proteostasis and quality control of membrane proteins will shed light on the molecular basis of neurodegenerative disorders and cancer.