Projects per year
Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.
Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.
8051- PPN - Poole - EBI MRC CiC - Development of a novel scalable system to generate platelets for transfusion
1/03/21 → 28/02/22
1/03/16 → 30/04/21
The Role of the Water Channel Aquaporin-1 in the Regulation of Platelet Function, Procoagulant activity and Thrombosis
10/11/17 → 9/11/20
Poole, A. W., Jayaraman, P. S. & Gaston, K., 4 Feb 2020, In: Oncogenesis. 9, 12 p., 10 (2020).
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile6 Citations (Scopus)66 Downloads (Pure)
Zhao, X., Williams, C. M., Aungraheeta, R., Hers, I., Swenson, E. R. & Poole, A. W., 1 Jan 2020, In: Platelets. 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile21 Downloads (Pure)
Poole, A. W., 1 Jul 2019, In: Cellular Signalling. 59, p. 34-40 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Citations (Scopus)231 Downloads (Pure)