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Professor Alastair W Poole

Vet.M.B., M.A., Ph.D.(Cantab.), M.R.C.V.S.

 https://orcid.org/0000-0002-0868-297X

  • BS8 1TD

20022020

Research output per year

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Personal profile

Research interests

Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.

Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.

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Projects

The Role of the Water Channel Aquaporin-1 in the Regulation of Platelet Function, Procoagulant activity and Thrombosis

Poole, A. W.

10/11/17 → 9/11/20

Project: Research

Platelet secretion: Control mechanisms and role in thrombosis, cardiac damage and repair

Poole, A. W.

1/03/16 → 28/02/21

Project: Research

Flexible Talent Mobility Account

Poole, A. W.

1/11/17 → 25/04/19

Project: Research

Research Output

  • 77 Article (Academic Journal)
  • 1 Conference Contribution (Conference Proceeding)
  • 1 Letter (Academic Journal)
  • 1 Review article (Academic Journal)

Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX

Marcolino, E., Siddiqui, Y. H., van den Bosch, M., Poole, A. W., Jayaraman, P. S. & Gaston, K., 4 Feb 2020, In : Oncogenesis. 9, 12 p., 10 (2020).

Research output: Contribution to journal › Article (Academic Journal)

Open Access
File
    • 28 Downloads (Pure)

    Carbonic Anhydrase Inhibitors Suppress Platelet Procoagulant Responses and In Vivo Thrombosis

    Agbani, E. O., Zhao, X., Williams, C. M., Aungraheeta, R., Hers, I., Swenson, E. R. & Poole, A. W., 1 Jan 2020, In : Platelets. 7 p.

    Research output: Contribution to journal › Article (Academic Journal)

    • Blood platelets stimulate cancer extravasation through 3 TGFβ-mediated down-regulation of PRH/HHEX

    Marcolino De Assis Junior, E., Siddiqui, Y. H., Van Den Bosch, M. T. J., Poole, A. W., Jayaraman, P-S. & Gaston, K., 23 Dec 2019, (Accepted/In press) In : Oncogenesis.

    Research output: Contribution to journal › Article (Academic Journal)

    • Supervised Work

    Identification and Elucidation of Novel Platelet Primers

    Author: Liu, H., 23 Jan 2019

    Supervisor: Hers, I. (Supervisor) & Poole, A. (Supervisor)

    Student thesis: Master's Thesis › Master of Science (MSc)

    File

    The Effect of Hyperglycaemia and Thrombopoietin on Platelet Function

    Author: Halliwell, S., 7 May 2019

    Supervisor: Hers, I. (Supervisor) & Poole, A. (Supervisor)

    Student thesis: Master's Thesis › Master of Science (MSc)

    File