Projects per year
Personal profile
Research interests
Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.
Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.
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Network
Projects
- 9 Finished
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8051- PPN - Poole - EBI MRC CiC - Development of a novel scalable system to generate platelets for transfusion
1/03/21 → 30/04/22
Project: Research
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The Role of the Water Channel Aquaporin-1 in the Regulation of Platelet Function, Procoagulant activity and Thrombosis
10/11/17 → 9/11/20
Project: Research
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Research output
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Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19
Goudswaard, L., Williams, C. M., Khalil, J. S., Burley, K. L., Hamilton, F. W., Arnold, D. T., Milne, A., Lewis, P., Heesom, K. J., Mundell, S. J., Davidson, A. D., Poole, A. W. & Hers, I., 27 Jan 2023, (E-pub ahead of print) In: Journal of Thrombosis and Haemostasis.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function
Trory, J. S., Munkacsi, A., Sledz, K., Goudswaard, L., Jackson, M. L., Heesom, K. J., Moore, S. F., Poole, A. W., Nabet, B., Aggarwal, V. K. & Hers, I., 7 Nov 2022, (E-pub ahead of print) In: Blood Advances.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function
Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T. J., Teasdale, J. E., Jones, M. L., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafo, M. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Bojesen, S. E., Relton, C. L., Min, J. L., & 4 others , 4 Feb 2022, In: Circulation Research. 130, 3, p. 384-400 17 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile39 Downloads (Pure)
Datasets
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Epigenetic regulation of F2RL3 in vitro in response to exposure to cigarette smoke extract
Corbin, L. J. (Creator), Williams, C. M. (Creator), White, S. J. (Creator), Taylor, A. E. (Creator), Taylor, K. (Creator), Poole, A. W. (Contributor), Timpson, N. J. (Contributor) & Mumford, A. D. (Contributor), University of Bristol, 23 Dec 2021
DOI: 10.5523/bris.35olm77woaku72652wg0g0j6nf, http://data.bris.ac.uk/data/dataset/35olm77woaku72652wg0g0j6nf
Dataset