Projects per year
Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.
Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.
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- 9 Finished
8051- PPN - Poole - EBI MRC CiC - Development of a novel scalable system to generate platelets for transfusion
1/03/21 → 30/04/22
The Role of the Water Channel Aquaporin-1 in the Regulation of Platelet Function, Procoagulant activity and Thrombosis
10/11/17 → 9/11/20
Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3activation in patients with COVID-19Goudswaard, L. J., Williams, C. M., Khalil, J., Burley, K. L., Hamilton, F., Arnold, D., Milne, A., Lewis, P. A., Heesom, K. J., Mundell, S. J., Davidson, A. D., Poole, A. W. & Hers, I., 12 Oct 2022
Research output: Other contribution
Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19Goudswaard, L., Williams, C. M., Khalil, J. S., Burley, K. L., Hamilton, F. W., Arnold, D. T., Milne, A., Lewis, P., Heesom, K. J., Mundell, S. J., Davidson, A. D., Poole, A. W. & Hers, I., 12 Oct 2022, (Submitted) In: Journal of Thrombosis and Haemostasis.
Research output: Contribution to journal › Article (Academic Journal)
Trory, J. S., Munkacsi, A., Sledz, K., Goudswaard, L., Jackson, M. L., Heesom, K. J., Moore, S. F., Poole, A. W., Nabet, B., Aggarwal, V. K. & Hers, I., 7 Nov 2022, (E-pub ahead of print) In: Blood Advances.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
Corbin, L. J. (Creator), Williams, C. M. (Creator), White, S. J. (Creator), Taylor, A. E. (Creator), Taylor, K. R. (Creator), Poole, A. W. (Contributor), Timpson, N. J. (Contributor) & Mumford, A. D. (Contributor), University of Bristol, 23 Dec 2021