Alastair W Poole

2024

Critical role for platelet Ral GTPases in regulating venous thrombosis in mice

Li, Y., Furniss, J. A., Vautrinot, J. J., Williams, C. M., Walsh, T. G., Brill, A., Amulic, B. & Poole, A. W., 24 Oct 2024, (E-pub ahead of print) In: Journal of Thrombosis and Haemostasis. 23, 1, p. 254-261 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

CryoET reveals actin filaments within platelet microtubules

Tsuji, C., Bradshaw, M., Allen, M. F., Jackson, M. L., Mantell, J. M., Borucu, U., Poole, A. W., Verkade, P., Hers, I., Paul, D. M. & Dodding, M. P., 16 Jul 2024, In: Nature Communications. 15, 1, 8 p., 5967 .

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Platelet generation in vivo and in vitro

Furniss, J. A., Tarassova, N. & Poole, A. W., 28 Nov 2024, In: Blood. 144, 22, p. 2283-2294 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

2023

Alterations in platelet proteome signature and impaired platelet integrin α_IIbβ₃ activation in patients with COVID-19

Goudswaard, L., Williams, C. M., Khalil, J. S., Burley, K. L., Hamilton, F. W., Arnold, D. T., Milne, A., Lewis, P., Heesom, K. J., Mundell, S. J., Davidson, A. D., Poole, A. W. & Hers, I., 1 May 2023, In: Journal of Thrombosis and Haemostasis. 21, 5, p. 1307-1321 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

11 Citations (Scopus)

Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Zhao, X., Alibhai, D. R., Walsh, T. G., Tarassova, N., Birol, S. Z., Li, Y., Hers, I. & Poole, A. W., 7 Jul 2023, In: Nature Communications. 14, 1, 4026 .

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

16 Citations (Scopus)

Pro-inflammatory role of Wnt/β-catenin signaling in endothelial dysfunction

Wadey, K. S., Somos, A., Leyden, G., Blythe, H., Chan, J., Hutchinson, L., Poole, A., Frankow, A., Johnson, J. L. & George, S. J., 17 Jan 2023, In: Frontiers in Cardiovascular Medicine. 9, 16 p., 1059124.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

11 Citations (Scopus)

2022

Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function

Trory, J. S., Munkacsi, A., Sledz, K., Goudswaard, L., Jackson, M. L., Heesom, K. J., Moore, S. F., Poole, A. W., Nabet, B., Aggarwal, V. K. & Hers, I., 7 Nov 2022, (E-pub ahead of print) In: Blood Advances.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function

Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T. J., Teasdale, J. E., Jones, M. L., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafo, M. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Bojesen, S. E., Relton, C. L. & Min, J. L. & 4 others, Davey Smith, G., Mumford, A. D., Poole, A. W. & Timpson, N. J., 4 Feb 2022, In: Circulation Research. 130, 3, p. 384-400 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

105 Downloads (Pure)

Exploring platelet proteins altered in severe COVID-19 using gene ontology (GO) pathways

Goudswaard, L., Burley, K. L., Williams, C. M., Heesom, K. J., Mundell, S. J., Poole, A. W. & Hers, I., 2022, (Accepted/In press).

Research output: Contribution to conference › Conference Abstract › peer-review

2021

Opposing roles of gsk3α and gsk3β phosphorylation in platelet function and thrombosis

Moore, S. F., Agbani, E. O., Wersall, J. A., Poole, A. W., Williams , C. M., Zhao, X., Li, Y., Hutchinson, J. L., Hunter, R. W. & Hers, I., 1 Oct 2021, In: International Journal of Molecular Sciences. 22, 19, p. 10656 20 p., 10656.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

117 Downloads (Pure)

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling

Zhao, X., Alibhai, D. R., Khalil, J. S., Williams , C. M., Li, Y., Sessions, R. B., Cross, S., Seager, R. A., Aungraheeta, M. S. R. H., Leard, A. D., McKinnon, C. M., Phillips, D. J., Poole, A. W., Banting, G. S. & Mundell, S. J., 13 Apr 2021, In: Blood Advances. 5, 7, p. 1884–1898 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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3 Citations (Scopus)

109 Downloads (Pure)

2020

Blood platelets stimulate cancer extravasation through 3 TGFβ-mediated down-regulation of PRH/HHEX

Marcolino, E., Siddiqui, Y. H., van den Bosch, M., Poole, A. W., Jayaraman, P. S. & Gaston, K., 4 Feb 2020, In: Oncogenesis. 9, 12 p., 10 (2020).

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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23 Citations (Scopus)

123 Downloads (Pure)

Carbonic Anhydrase Inhibitors Suppress Platelet Procoagulant Responses and In Vivo Thrombosis

Agbani, E. O., Zhao, X., Williams, C. M., Aungraheeta, R., Hers, I., Swenson, E. R. & Poole, A. W., 2 Oct 2020, In: Platelets. 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

13 Citations (Scopus)

318 Downloads (Pure)

2019

Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets

Walsh, T. G., Wersäll, A. & Poole, A. W., 1 Jul 2019, In: Cellular Signalling. 59, p. 34-40 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

283 Downloads (Pure)

Letter by Agbani et al Regarding Article, "clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface"

Agbani, E. O., Hers, I. & Poole, A. W., 26 Nov 2019, (Accepted/In press) In: Arteriosclerosis, Thrombosis, and Vascular Biology. 39, p. E287-E289 3 p.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

2 Citations (Scopus)

Small GTPases in platelet membrane trafficking

Poole, A., Li, Y., Wersall, A. & Poole, A. W., 2 Jan 2019, In: Platelets. 30, 1, p. 31-40 10 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

350 Downloads (Pure)

2018

Aquaporin-1 Regulates Platelet Procoagulant Membrane Dynamics and In Vivo Thrombosis

Agbani, E., Williams, C., Li, Y., van den Bosch, M., Moore, S., Mauroux, A., Hodgson, L., Verkman, A. S., Hers, I. & Poole, A., 17 May 2018, In: JCI Insight. 3, 10, 16 p., e99062.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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29 Citations (Scopus)

357 Downloads (Pure)

Do platelets promote cardiac recovery after myocardial infarction: Roles beyond occlusive ischemic damage

Walsh, T. G. & Poole, A. W., May 2018, In: AJP - Heart and Circulatory Physiology. 314, 5, p. H1043-H1048 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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27 Citations (Scopus)

279 Downloads (Pure)

Loss of the mitochondrial kinase PINK1 does not alter platelet function

Walsh, T. G., van den Bosch, M. T. J., Lewis, K. E., Williams, C. M. & Poole, A. W., 1 Dec 2018, In: Scientific Reports. 8, 1, 8 p., 14377.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

336 Downloads (Pure)

Mouse platelet Ral GTPases control P-selectin surface expression, regulating platelet-leukocyte interaction

Wersall, A., Williams, C., Brown, E., Iannitti, T., Williams, N. & Poole, A., 1 Apr 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 4, p. 787-800 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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23 Citations (Scopus)

259 Downloads (Pure)

Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels: Megakaryocytes migrate by membrane extrusion

Brown, E., Carlin, L. M., Nerlov, C., Lo Celso, C. & Poole, A., May 2018, In: Life Science Alliance. 1, 2, 12 p., e201800061.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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40 Citations (Scopus)

265 Downloads (Pure)

Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation

Blair, T. A., Moore, S. F., Walsh, T. G., Hutchinson, J. L., Durrant, T. N., Anderson, K. E., Poole, A. W. & Hers, I., Oct 2018, In: Cellular Signalling. 50, p. 111-120 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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13 Citations (Scopus)

427 Downloads (Pure)

Platelet-specific deletion of SNAP23 ablates granule secretion, substantially inhibiting arterial and venous thrombosis in mice

Williams, C., Li, Y., Brown, E. & Poole, A., 26 Dec 2018, In: Blood Advances. 2, 24, p. 3627-3636 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

315 Downloads (Pure)

2017

Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation: Synchronised ballooning and microvesiculation

Agbani, E., Williams, C., Hers, I. & Poole, A., 5 Jun 2017, In: Scientific Reports. 7, 1, 12 p., 2770.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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43 Citations (Scopus)

383 Downloads (Pure)

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis

Lauder, S. N., Allen-Redpath, K., Slatter, D. A., Aldrovandi, M., O'Connor, A., Farewell, D., Percy, C. L., Molhoek, J. E., Rannikko, S., Tyrrell, V. J., Ferla, S., Milne, G. L., Poole, A. W., Thomas, C. P., Obaji, S., Taylor, P. R., Jones, S. A., de Groot, P. G., Urbanus, R. T. & Hörkkö, S. & 7 others, Uderhardt, S., Ackermann, J., Vince Jenkins, P., Brancale, A., Krönke, G., Collins, P. W. & O'Donnell, V. B., 28 Nov 2017, In: Science Signaling. 10, 507, 19 p., eaan2787.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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43 Citations (Scopus)

357 Downloads (Pure)

Platelets protect cardiomyocytes from ischaemic damage

Walsh, T. & Poole, A., Jun 2017, In: TH Open. 1, 1, p. e24-e32 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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466 Downloads (Pure)

Procoagulant platelets: - generation, function and therapeutic targeting in thrombosis

Agbani, E. & Poole, A., 16 Nov 2017, In: Blood. 130, 20, p. 2171-2179 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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143 Citations (Scopus)

413 Downloads (Pure)

Temporal contribution of the platelet body and balloon to thrombin generation

Agbani, E., Hers, I. & Poole, A., 13 Jul 2017, (E-pub ahead of print) In: Haematologica.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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27 Citations (Scopus)

318 Downloads (Pure)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin αIIbβ3 Outside-in Signaling

Battram, A., Durrant, T., Agbani, E., Heesom, K., Paul, D. S., Piatt, R., Poole, A., Cullen, P., Bergmeier, W., Moore, S. & Hers, I., 3 Feb 2017, In: Journal of Biological Chemistry. 292, 5, p. 1691-1704 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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38 Citations (Scopus)

360 Downloads (Pure)

2016

Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets

Williams, C., Savage, J., Harper, M., Moore, S., Hers, I. & Poole, A., Jun 2016, In: Platelets. p. 286-94

Research output: Contribution to journal › Article (Academic Journal) › peer-review

9 Citations (Scopus)

Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases

Poole, A., Crescente, M., Pluthero, F. G., Walsh, T., Gibbins, J. M. & Kahr, W. H., Jun 2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 6, p. 1164-1173 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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53 Citations (Scopus)

376 Downloads (Pure)

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage

Mattheij, N. J. A., Braun, A., van Kruchten, R., Castoldi, E., Pircher, J., Baaten, C. C. F. M. J., Wülling, M., Kuijpers, M. J. E., Köhler, R., Poole, A. W., Schreiber, R., Vortkamp, A., Collins, P. W., Nieswandt, B., Kunzelmann, K., Cosemans, J. M. E. M. & Heemskerk, J. W. M., Feb 2016, In: FASEB Journal. 30, 2, p. 727-737 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

51 Citations (Scopus)

2015

Coordinated membrane ballooning and procoagulant-spreading in human platelets

Agbani, E., Van den Bosch, M., Brown, E., Williams, C., Mattheij, N., Cosemans, J. M. E. M., Collins, P., Heemskerk, J. W. M., Hers, I. & Poole, A., 13 Oct 2015, In: Circulation. 132, 15, p. 1414-1424 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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131 Citations (Scopus)

549 Downloads (Pure)

Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice

Williams, C. M., Harper, M. T., Goggs, R. A. N., Walsh, T. G., Offermanns, S. & Poole, A. W., 6 Nov 2015, In: Journal of Thrombosis and Haemostasis. 13, 11, p. 2102-2107 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

9 Citations (Scopus)

555 Downloads (Pure)

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling

Moore, S. F., Williams, C. M., Brown, E., Blair, T. A., Harper, M. T., Coward, R. J., Poole, A. W. & Hers, I., 22 Apr 2015, In: Cardiovascular Research.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

40 Citations (Scopus)

Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets

Harper, M. T., van den Bosch, M. T., Hers, I. & Poole, A. W., 7 May 2015, In: Blood. 125, 19, p. 3034-6 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

27 Citations (Scopus)

Platelet Rho GTPases-a focus on novel players, roles and relationships

Goggs, R., Williams, C. M., Mellor, H. & Poole, A. W., 15 Mar 2015, In: Biochemical Journal. 466, 3, p. 431-42 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

45 Citations (Scopus)

SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4

Poole, A., Walsh, T. & Harper, M., 2015, In: Cellular Signalling. 27, p. 37-46 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation and Thrombus Stability

Golebiewska, E., Harper, M., Williams, C., Goggs, R., Savage, J., Fischer von Mollard, G. & Poole, A., 2015, In: Journal of Biological Chemistry. 290, p. 1536-1545 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

31 Citations (Scopus)

The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62

Bell, K. S., Al-Riyami, L., Lumb, F. E., Britton, G. J., Poole, A. W., Williams, C. M., Braun, U., Leitges, M., Harnett, M. M. & Harnett, W., Nov 2015, In: Immunology Letters. 168, 1, p. 31-40 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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16 Citations (Scopus)

365 Downloads (Pure)

2014

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6

van den Bosch, M. T. J., Poole, A. W. & Hers, I., May 2014, In: Journal of Thrombosis and Haemostasis. 12, 5, p. 726-35 10 p.

Research output: Contribution to journal › Article (Academic Journal)

17 Citations (Scopus)

Is JAK2V617F finally off the hook?

Hers, I. & Poole, A. W., 14 Aug 2014, In: Blood. 124, 7, p. 992-3 2 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming

Blair, T. A., Moore, S. F., Williams, C. M., Poole, A. W., Vanhaesebroeck, B. & Hers, I., Aug 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 8, p. 1681-8 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

36 Citations (Scopus)

Protein kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity*

Galea, G. L., Meakin, L. B., Williams, C. M., Hulin-Curtis, S. L., Lanyon, L. E., Poole, A. W. & Price, J. S., 12 Sept 2014, In: Journal of Biological Chemistry. 289, 37, p. 25509-25522 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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28 Citations (Scopus)

511 Downloads (Pure)

2013

Absence of platelet phenotype in mice lacking the motor protein myosin Va

Harper, M. T., van den Bosch, M. T. J., Hers, I. & Poole, A. W., 2013, In: PLoS ONE. 8, 1, p. e53239

Research output: Contribution to journal › Article (Academic Journal) › peer-review

6 Citations (Scopus)

Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity

Harper, M. T. & Poole, A. W., 2013, In: Cell Death and Disease. 19, p. e969

Research output: Contribution to journal › Article (Academic Journal) › peer-review

45 Citations (Scopus)

Comment on "Platelet-derived nucleotides promote tumor cell transendothelial migration and metastasis via P2Y2 receptor" by Schumacher et al.

Harper, M. T. & Poole, A. W., 2013, In: Cancer Cell. 24, 3, p. 287 1 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt Promotes Thrombin-mediated Integrin alpha(IIb)beta(3) Activation and Granule Secretion in Platelets

Moore, S. F., van den Bosch, M. T. J., Hunter, R. W., Sakamoto, K., Poole, A. W. & Hers, I., 8 Feb 2013, In: Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

122 Citations (Scopus)

Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia

Moore, S. F., Hunter, R. W., Harper, M. T., Savage, J. S., Siddiq, S., Westbury, S. K., Poole, A. W., Mumford, A. D. & Hers, I., 2013, In: Blood. 121, 7, p. 1209-19 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

39 Citations (Scopus)

Munc13-4 is critical for thrombosis through regulating release of ADP from platelets

Savage, J. S., Williams, C. M., Konopatskaya, O., Hers, I., Harper, M. T. & Poole, A. W., Apr 2013, In: Journal of Thrombosis and Haemostasis. 11, 4, p. 771-5 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

30 Citations (Scopus)

Professor Alastair W Poole

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