20052020

Research output per year

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Personal profile

Research interests

  • The role of hypoxia (reduced tissue oxygen levels) in the tumour microenvironment
  • Signal transduction pathways in cancer development (particularly Wnt/β-catenin and Hippo-YAP/TAZ)
  • The role of autophagy in tissue homeostasis and cancer
  • Apoptosis and tumour cell survival 
  • Cyclooxygenases (COX1 and COX2) and prostaglandins (particularly PGE2)
  • Three-dimensional models of normal and cancer tissue (spheroid & organoid culture)
  • Post-translational modifications and cancer epigenetics
  • Drug resistance & novel targets for cancer therapy 

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Research Output

  • 29 Article (Academic Journal)
  • 1 Editorial (Academic Journal)

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

Szemes, M., Bellamy, J., Melegh, Z., Greenhough, A., Kollareddy, M., Catchpoole, D. & Malik, K., 23 Mar 2020, In : Cells. 9, 3, 18 p., 783.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 38 Downloads (Pure)

    BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

    Legge, D., Shephard, A., Collard, T., Greenhough, A., Chambers, A., Clarkson, R., Paraskeva, C. & Williams, A., 4 Mar 2019, In : Disease Models and Mechanisms. 12, 3, 12 p., dmm037697.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 5 Citations (Scopus)
    171 Downloads (Pure)

    LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

    Morgan, R., Ridsdale, J., Payne, M., Heesom, K., Wilson, M. C., Davidson, A., Greenhough, A., Davies, S., Williams, A., Blair, A., Waterman, M. L., Tonks, A. & Darley, R., 1 Jul 2019, In : Haematologica. 104, 7, p. 1365-1377 13 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 8 Citations (Scopus)
    321 Downloads (Pure)

    Prizes

    Academy of Medical Sciences Poster & Presentation Prize (Finalist)

    Greenhough, Alex (Recipient), May 2017

    Prize: Prizes, Medals, Awards and Grants

    Art of Science Prize

    Greenhough, Alex (Recipient), Dec 2012

    Prize: Prizes, Medals, Awards and Grants

  • BACR Prize for Best Overall Presentation

    Greenhough, Alex (Recipient), Jul 2016

    Prize: Prizes, Medals, Awards and Grants

  • Activities

    • 1 Public talk, debate, discussion

    Invited interview broadcast on BBC Radio Bristol (5pm, 24th August 2018)

    Alexander Greenhough (Advisor)

    24 Aug 2018

    Activity: Talk or presentation typesPublic talk, debate, discussion