Research output per year
Research output per year
BSc, M.Sc., Ph.D.
BS8 1TD
There is considerable overlap between the neural circuits that control breathing and those that control the cardiovascular system. Often dysfunctions in these systems are connected and should be addressed as a whole. Respiratory dysrhythmias are positively associated with increased cardiovascular risk and sudden death. Some types of respiratory arrhythmia are highly prevalent, like obstructive sleep apnoea (OSA). It affects between 9 to 38% of the adult population worldwide. In some elderly groups, OSA affects 90% of men and 78% of women. Most people remain undiagnosed and it is estimated that 1.5 million UK adults have OSA. There is no effective drug treatment, and the currently available treatment options are sub-optimal. My research group aims to address such unmet clinical needs.
We use preclinical models to identify and validate novel therapeutic targets to treat respiratory dysrhythmias and sympatho-vagal dysfunction. We are interested in the circuit dynamics of respiratory and cardiovascular centres, from rhythm and pattern formation to systems level. During preclinical stages, we also collaborate with mathematicians to develop realistic multiscale computational models of the respiratory and cardiovascular systems, which support the validation of newly identified targets. Through collaborations with a solid network of clinical researchers, we are able to take new discoveries into proof-of-principle studies in humans.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Abdala Sheikh, A. P. (Principal Investigator)
1/03/15 → 5/01/16
Project: Research
Abdala Sheikh, A. P. (Co-Investigator) & Paton, J. F. R. (Principal Investigator)
1/01/15 → 31/01/18
Project: Research
Abdala Sheikh, A. P. (Co-Principal Investigator) & Paton, J. F. R. (Co-Principal Investigator)
1/08/14 → 31/07/16
Project: Research
Abdala Sheikh, A. P. (Speaker)
Activity: Talk or presentation types › Schools engagement
Abdala Sheikh, A. P. (Speaker)
Activity: Talk or presentation types › Schools engagement
Abdala Sheikh, A. P. (Invited speaker)
Activity: Participating in or organising an event types › Participation in conference