Personal profile

Research interests

There is considerable overlap between the neural circuits that control breathing and those that control the cardiovascular system. Often dysfunctions in these systems are connected and should be addressed as a whole. Respiratory dysrhythmias are positively associated with increased cardiovascular risk and sudden death. Some types of respiratory arrhythmia are highly prevalent, like obstructive sleep apnoea (OSA). It affects between 9 to 38% of the adult population worldwide. In some elderly groups, OSA affects 90% of men and 78% of women. Most people remain undiagnosed and it is estimated that 1.5 million UK adults have OSA. There is no effective drug treatment, and the currently available treatment options are sub-optimal. My research group aims to address such unmet clinical needs.

We use preclinical models to identify and validate novel therapeutic targets to treat respiratory dysrhythmias and sympatho-vagal dysfunction. We are interested in the circuit dynamics of respiratory and cardiovascular centres, from rhythm and pattern formation to systems level. During preclinical stages, we also collaborate with mathematicians to develop realistic multiscale computational models of the respiratory and cardiovascular systems, which support the validation of newly identified targets. Through collaborations with a solid network of clinical researchers, we are able to take new discoveries into proof-of-principle studies in humans.


  • obstructive sleep apnoea
  • central apnoea
  • Rett syndrome
  • Pitt-Hopkins syndrome
  • hypertension
  • heart failure
  • carotid body
  • breathing


Dive into the research topics where Ana Paula Abdala Sheikh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or