Research Output per year
Personal profile
Research interests
Group: Inflammatory Eye Disease Group
My group's work and that of others in ophthalmology focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include:
- The control of immune responses in the retina which includes for example the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression
- Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity
- Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration
- Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells
- Role of macrophages in retinal and choroidal angiogenesis
- Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis
Clinically we are undertaking significant advances in human ocular immunology through both our lead of Inflammation and immunotherapeutics of Biomedical Research Centre at Moorfields Eye Hospital and UCL-Institute of Ophthalmology. This includes:
(i) proof of concept early phase trials of immunotherapeutics.
(ii) Understanding of immune responses via live in vivo imaging of leukocytes through the retinal and choroidal vasculature in man.
(iii) progressing with development of gene therapy for treatment of uveitis
Present collaborators
- Dr Lindsay Nicholson, Schoool of Cellular and Molecular Medicine
- Dr Richard Lee, School of Clinical Sciences
- Dr Denize Atan, School of Clinical Sciences
- Dr Bob Nussenblatt, National Eye Institute, USA
- Professor R Ali, Institute of Ophthalmology and Institute of Child Health, UCL
- Professor John Forrester, University of Aberdeen
- Professor Jim Bainbridge, Institute of Ophthalmology, UCL
- Professor Mike Boulton, Indiana University School of Medicine
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Research Output
Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK
POIG Uveitis Delphi Group, 1 Jan 2020, In : British Journal of Ophthalmology. 104, 1, p. 11-16 6 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
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Features of ectopic lymphoid-like structures in human uveitis
Epps, S. J., Coplin, N., Luthert, P. J., Dick, A. D., Coupland, S. E. & Nicholson, L. B., 1 Feb 2020, In : Experimental Eye Research. 191, 9 p., 107901.Research output: Contribution to journal › Article (Academic Journal)
Open Access
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Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 disruption using CRISPR-Cas9
Wu, J., Bell, O. H., Copland, D. A., Young, A., Pooley, J. R., Maswood, R., Evans, R. S., Khaw, P., Ali, R. R., Dick, A. D. & Chu, C. J., 9 Jan 2020, In : Molecular Therapy. 10 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Supervised Work
The interplay between innate immunity and metabolism in the retinal pigment epithelium
Author: Scott, L. M., 28 Nov 2019Supervisor: Dick, A. (Supervisor) & Theodoropoulou, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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