Professor Andrew David Dick

B.Sc., M.B.B.S.(Lond.), M.D.(Aberd.), M.R.C.P.(UK), F.R.C.S.(Lond.), F.R.C.S.(Edin.), F.R.C.P.(Edin.), F.R.C.Ophth, FMedSci

  • BS1 2LX

19962020

Research output per year

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Personal profile

Research interests

Group: Inflammatory Eye Disease Group

My group's work and that of others in ophthalmology focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include:

  1. The control of immune responses in the retina which includes for example the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression
  2. Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity
  3. Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration
  4. Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells
  5. Role of macrophages in retinal and choroidal angiogenesis
  6. Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis

Clinically we are undertaking significant advances in human ocular immunology through both our lead of Inflammation and immunotherapeutics of Biomedical Research Centre at Moorfields Eye Hospital and UCL-Institute of Ophthalmology. This includes:

(i) proof of concept early phase trials of immunotherapeutics.

(ii) Understanding of immune responses via live in vivo imaging of leukocytes through the retinal and choroidal vasculature in man.

(iii) progressing with development of gene therapy for treatment of uveitis

 Present collaborators

  • Dr Lindsay Nicholson, Schoool of Cellular and Molecular Medicine
  • Dr Richard Lee, School of Clinical Sciences
  • Dr Denize Atan, School of Clinical Sciences
  • Dr Bob Nussenblatt, National Eye Institute, USA
  • Professor R Ali, Institute of Ophthalmology and Institute of Child Health, UCL
  • Professor John Forrester, University of Aberdeen
  • Professor Jim Bainbridge, Institute of Ophthalmology, UCL
  • Professor Mike Boulton, Indiana University School of Medicine

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Research Output

Activation of C-Reactive Protein Proinflammatory Phenotype in the blood retinal barrier in vitro: Implications for Age-related Macular Degeneration

Romero-Vázquez, S., Adán, A., Figueras-Roca, M., Llorenç, V., Slevin, M., Vilahur, G., Badimon, L., Dick, A. D. & Molins, B., 16 Jul 2020, In : Aging. 12, 19 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 15 Downloads (Pure)

    Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK

    POIG Uveitis Delphi Group, 1 Jan 2020, In : British Journal of Ophthalmology. 104, 1, p. 11-16 6 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 2 Citations (Scopus)
    200 Downloads (Pure)

    Features of ectopic lymphoid-like structures in human uveitis

    Epps, S. J., Coplin, N., Luthert, P. J., Dick, A. D., Coupland, S. E. & Nicholson, L. B., 1 Feb 2020, In : Experimental Eye Research. 191, 9 p., 107901.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 1 Citation (Scopus)
    59 Downloads (Pure)

    Supervised Work

    The interplay between innate immunity and metabolism in the retinal pigment epithelium

    Author: Scott, L. M., 28 Nov 2019

    Supervisor: Dick, A. (Supervisor) & Theodoropoulou, S. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File