20042020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 50 Article (Academic Journal)
  • 2 Comment/debate (Academic Journal)
  • 1 Conference Abstract
  • 1 Conference Paper
Article (Academic Journal)

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

Kim, S. J., Zhang, H., Khaliulin, I., Choisy, S. C. M., Bond, R. C., Lin, H., El Haou, S., Milnes, J. T., Hancox, J. C., Suleiman, M. S. & James, A. F., 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 6, p. 1184-1192

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

A hERG mutation E1039X produced a synergistic lesion on I Ks together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

Wu, J., Mizusawa, Y., Ohno, S., Ding, W. G., Higaki, T., Wang, Q., Kohjitani, H., Makiyama, T., Itoh, H., Toyoda, F., James, A. F., Hancox, J. C., Matsuura, H. & Horie, M., 15 Feb 2018, In : Scientific Reports. 8, 1, 12 p., 3129.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
249 Downloads (Pure)

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

Bryant, S. M., Kong, C. H. T., Watson, J., Cannell, M. B., James, A. F. & Orchard, C. H., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 23–31 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
29 Citations (Scopus)
341 Downloads (Pure)

Altered Na/Ca exchange distribution and activity in ventricular myocytes from failing hearts

Gadeberg, H. C., Bryant, S. M., James, A. F. & Orchard, C. H., 15 Jan 2016, In : AJP - Heart and Circulatory Physiology. 310, 2, p. H262-H268 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
159 Downloads (Pure)

A multicentre study of patients with Timothy syndrome

Walsh, M. A., Turner, C., Timothy, K. W., Seller, N., Hares, D. L., James, A. F., Hancox, J. C., Uzun, O., Boyce, D., Stuart, A. G., Brennan, P., Sarton, C., McGuire, K., Newbury-Ecob, R. A. & Mcleod, K., 1 Feb 2018, In : EP-Europace. 20, 2, p. 377-385 9 p., euw433.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
275 Downloads (Pure)

Atrial Remodeling and the Substrate for Atrial Fibrillation in Rat Hearts with Elevated Afterload

Kim, SJ., Choisy, SCM., Barman, P., Zhang, H., Hancox, JC., Jones, SA. & James, AF., Oct 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, 5, p. 761 - 769 9 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: basis for atrial-selective block by ranolazine

Caves, R., Cheng, H., Choisy, S., Gadeberg, H., Bryant, S., Hancox, J. & James, A., 1 Nov 2017, In : Heart Rhythm. 14, 11, p. 1657-1664 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
250 Downloads (Pure)

A TRPC-like non-selective cation current activated by α1-adrenoceptors in rat mesenteric artery smooth muscle cells

Hill, AJ., Hinton, JM., Cheng, H., Gao, Z., Bates, DO., Hancox, JC., Langton, PD. & James, AF., Jul 2006, In : Cell Calcium. 40 (1), p. 29 - 40 12 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101

Barman, P., Choisy, SCM., Gadeberg, HC., Hancox, JC. & James, AF., 2011, In : Biochemical and Biophysical Research Communications. 408, p. 12 - 17

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Cardiac-specific overexpression of caveolin-3 preserves t-tubular I Ca during heart failure in mice

Kong, C. H. T., Bryant, S. M., Watson, J. J., Roth, D. M., Patel, H. H., Cannell, M. B., James, A. F. & Orchard, C. H., 1 May 2019, In : Experimental Physiology. 104, 5, p. 654-666 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
195 Downloads (Pure)

Caveolin-3 dependent loss of t-tubular ICa during hypertrophy and heart failure in mice

Bryant, S. M., Kong, C. H. T., Watson, J. J., Gadeberg, H. C., James, A. F., Cannell, M. B. & Orchard, C. H., 1 May 2018, In : Experimental Physiology. 103, 5, p. 652-665 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
267 Downloads (Pure)

Caveolin-3 KO Disrupts T-Tububle Structure and Decreases T-Tubular ICa Density in Mouse Ventricular Myocytes

Bryant, S., Kong, C., Watson, J., Gadeberg, H., Roth, D. M., Patel, H., Cannell, M., James, A. & Orchard, C., Nov 2018, In : AJP - Heart and Circulatory Physiology. 315, 5, p. H1101-H1111 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
173 Downloads (Pure)

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload

Zhang, H., Cannell, M. B., Kim, S. J., Watson, J. J., Norman, R., C. Calaghan, S., Orchard, C. & James, A. F., 29 Dec 2015, In : PLoS ONE. 10, 12, 17 p., e0144309.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
277 Downloads (Pure)

Characterization and influence of cardiac background sodium current in the atrioventricular node

Cheng, H., Li, J., James, A. F., Inada, S., Choisy, S. C. M., Orchard, C. H., Zhang, H., Boyett, M. R. & Hancox, J. C., Aug 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 114-124 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
280 Downloads (Pure)

Cholesterol depletion does not alter the capacitance or Ca handling of the surface or t-tubule membranes in mouse ventricular myocytes

Gadeberg, H., Kong, C., Bryant, S., James, A. & Orchard, C., 30 Nov 2017, In : Physiological Reports. 5, 22, 7 p., e13500.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
215 Downloads (Pure)

Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Khaliulin, I., Halestrap, A. P., Bryant, S. M., Dudley, D. J., James, A. F. & Suleiman, M. S., 2014, In : Journal of Translational Medicine. 12, p. 139

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Clustering of protein kinase A-dependent CFTR chloride channels in the sarcolemma of guinea-pig ventricular myocytes

James, AF., Sabirov, RZ. & Okada, Y., 1 Jan 2010, In : Biochemical and Biophysical Research Communications. 391, 1, p. 841 - 845 5 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

Walsh, M. A., Stuart, A. G., Schlecht, H., James, A. F., Hancox, J. C. & Newbury-Ecob, R. A., May 2016, In : Pacing and Clinical Electrophysiology. 39, 5, p. 497-501 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?

Orchard, C. H., Bryant, S. M. & James, A. F., 7 May 2013, In : Journal of Physiology. 591, 17, p. 4141-4147 7 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S-J., Hancox, J. C., Jones, S. A. & James, A. F., 1 Jan 2015, In : Physiological Reports. 3, 1

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Choisy, S. C., Cheng, H., Orchard, C. H., James, A. F. & Hancox, J. C., Nov 2015, In : Physiological Reports. 3, 11, 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
256 Downloads (Pure)

Evidence for a novel K+ channel modulated by α1A-adrenoceptors in cardiac myocytes

Choisy, SCM., Hancox, JC., Arberry, LA., Reynolds, AM., Shattock, MJ. & James, AF., Sep 2004, In : Molecular Pharmacology. 66 (3), p. 735 - 748 14 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac

Khaliulin, I., Bond, M., James, A. F., Dyar, Z., Amini, R., Johnson, J. L. & Suleiman, M-S., 24 Feb 2017, In : British Journal of Pharmacology. 174, 6, p. 438-453 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
285 Downloads (Pure)

Gender-related differences in ventricular myocyte repolarization in the guinea pig

James, AF., Arberry, LA. & Hancox, JC., May 2004, In : Basic Research in Cardiology. 99 (3), p. 183 - 192 10 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Heterogeneity of T-Tubules in Pig Hearts

Gadeberg, H. C., Bond, R. C., Kong, C., Chanoit, G., Ascione, R., Cannell, M. & James, A., 9 Jun 2016, In : PLoS ONE. 11, 6, 16 p., e0156862.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
350 Downloads (Pure)

Increased Susceptibility to Atrial Tachyarrhythmia in Spontaneously Hypertensive Rat Hearts

Choisy, SCM., Arberry, LA., Hancox, JC. & James, AF., Mar 2007, In : Hypertension. 49 (3), p. 498 - 505 8 p., HYP.0000257123.95372.ab.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)
72 Citations (Scopus)

Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes

Bond, R. C., Choisy, S. C. M., Bryant, S. M., Hancox, J. C. & James, A. F., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 206-15 10 p.

Research output: Contribution to journalArticle (Academic Journal)

File
8 Citations (Scopus)
331 Downloads (Pure)

Inhibition of the cardiac L-type calcium channel current by the trpm8 agonist, (-)-menthol

Baylie, RL., Cheng, H., Langton, PD. & James, AF., Oct 2010, In : Journal of Physiology and Pharmacology. 61, p. 543 - 550 8 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes

Caves, R. E., Carpenter, A., Choisy, S. C. M., Clennell, B., Cheng, H., McNiff, C., Mann, B., Milnes, J. T., Hancox, J. C. & James, A. F., 19 May 2020, (Accepted/In press) In : Heart Rhythm O2.

Research output: Contribution to journalArticle (Academic Journal)

Ion currents, action potentials and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes

Bond, R. C., Choisy, S. C., Bryant, S. M., Hancox, J. C. & James, A. F., 13 May 2020, In : Physiological Reports. 8, 9, 16 p., e14432.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
22 Downloads (Pure)

Loss of caveolin-3-dependent regulation of ICa in rat ventricular myocytes in heart failure

Bryant, S. M., Kong, C. H. T., Cannell, M. B., Orchard, C. H. & James, A. F., 1 Apr 2018, In : AJP - Heart and Circulatory Physiology. 314, 3, p. H521-H529

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
163 Downloads (Pure)

Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart

Choisy, S. C. M., Cheng, H., Smith, G., James, A. F. & Hancox, J. C., 29 Mar 2012, In : PLoS ONE. 7, 3, p. e33448

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Modulation by testosterone of an endogenous hERG potassium channel current

Ridley, JM., Shuba, YM., James, AF. & Hancox, JC., 2008, In : Journal of Physiology and Pharmacology. 59, p. 395 - 407

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

Barman, P. P., Cheng, H., Hancox, J. C. & James, A. F., 1 Mar 2013, In : Biochemical and Biophysical Research Communications. 432, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In : Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Cheng, H., Du, C., Zhang, Y., James, A., Dempsey, C., Abdala, A. P. & Hancox, J., 1 Oct 2019, In : Journal of Molecular and Cellular Cardiology. 135, p. 22-30 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
168 Downloads (Pure)

Recent advances in understanding sex differences in cardiac repolarization

James, AF., Choisy, SCM. & Hancox, JC., Jul 2007, In : Progress in Biophysics and Molecular Biology. 94 (3), p. 265 - 319 55 p.

Research output: Contribution to journalArticle (Academic Journal)

123 Citations (Scopus)

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In : AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
191 Downloads (Pure)

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel

Hancox, JC. & James, AF., 2008, In : Molecular Pharmacology. 73, p. 1592 - 1595

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)

Sarcolemmal distribution of ICa and INCX and Ca autoregulation in mouse ventricular myocytes

Gadeberg, H., Kong, C., Bryant, S., James, A. & Orchard, C., 1 Jul 2017, In : AJP - Heart and Circulatory Physiology. 313, 1, p. H190-H199 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
274 Downloads (Pure)

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes

Hancock, J. M., Weatherall, K. L., Choisy, S. C., James, A. F., Hancox, J. C. & Marrion, N. V., May 2015, In : Heart Rhythm. 12, 5, p. 1003-15 13 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Short QT interval linked to androgen misuse: wider significance and possible basis

Hancox, JC., Choisy, SCM. & James, AF., 2009, In : Annals of Noninvasive Electrocardiology. 14, p. 311 - 312

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes

Bryant, S., Kimura, T. E., Kong, C. H. T., Watson, J. J., Chase, A., Suleiman, M. S., James, A. F. & Orchard, C. H., 9 Jan 2014, In : Journal of Molecular and Cellular Cardiology.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

The Effects of Aging on the Regulation of T-Tubular i Ca by Caveolin in Mouse Ventricular Myocytes

Kong, C. H. T., Bryant, S. M., Watson, J. J., Gadeberg, H. C., Roth, D. M., Patel, H. H., Cannell, M. B., Orchard, C. H. & James, A. F., 9 May 2018, In : Journals of Gerontology, Series A. 73, 6, p. 711-719 9 p., glx242.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
231 Downloads (Pure)
27 Citations (Scopus)

VEGF activates receptor-operated cation channels in human microvascular endothelial cells

Cheng, H., James, AF., Foster, RR., Hancox, JC. & Bates, DO., Aug 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (8), p. 1768 - 1776 9 p.

Research output: Contribution to journalArticle (Academic Journal)

91 Citations (Scopus)

β-Adrenoceptor/PKA-stimulation, Na(+)-Ca(2+) exchange and PKA-activated Cl(-) currents in rabbit cardiomyocytes: A conundrum

Barman, P., Choisy, SCM., Hancox, JC. & James, AF., 2011, In : Cell Calcium. 49, p. 233 - 239

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)