Research output per year
Research output per year
BS2 8HW
My current research aims to develop a method of arterialising human saphenous veins (hSV) for use in coronary artery bypass surgery. An ongoing issue, with detrimental health and economic costs, is the development of thrombosis and lack of graft patency in 50% of autologous or synthetic venous grafts within 10 years of implant. Arterial conduits have been shown to remain patent in >95% of cases at 15-20 years post-bypass, and have improved long-term mortality rates. However, only ~20% of bypass grafts are performed using autologous arteries due to difficulties obtaining tissue and the likelihood of ageing-related arterial disease e.g. atherosclerosis. Using our bioreactor in vitro system, which allows us to perfuse the conduits at venous to arterial pulsatile pressures, we hope to develop cell seeding strategies and modify haemodynamic properties to turn decellularised hSVs into arteries for implant, which remain patent.
Following an 18-month change in research direction, developing methods to optimise islet cell transplantation in patients with Type I diabetes, this project returns to my scientific roots in cardiovascular research. My PhD at Imperial College London, and subsequent postdoctoral research in Bristol Heart Institute, focussed on changes in blood flow patterns, wall shear stress (haemodynamics), vessel wall mechanics and their effects on atherosclerosis development and atherosclerotic plaque rupture.
In Bristol, we are in the unique position of having the recently opened Translational Biomedical Research Centre (TBRC) for large animal work, and also have access to patient samples through the Bristol Royal infirmary and Bristol Children’s Hospital.
Projects:
University of Bristol: June 2017-May 2020
University of Bristol: September 2016-May 2017
University of Edinburgh: April 2016-June 2016
University of Edinburgh: November 2014-April 2016
University of Bristol: April 2014-September 2014
Roche Postdoctoral Fellowship/University of Bristol: March 2011-April 2014
University of Bristol: February 2008-March 2011
PhD, Imperial College London: 2003-2007
Young Committee Member, BSCR
1 Jan 2014 → 31 Dec 2020
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Bond, A. R. (Principal Investigator)
1/06/17 → 31/05/20
Project: Research
Bond, A. R. (Organiser), Thomas, A. C. (Organiser), Avolio, E. (Organiser) & Carrabba, M. (Organiser)
Activity: Participating in or organising an event types › Participation in conference