20052020

Research output per year

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Personal profile

Research interests

Astrocytes, the most abundant type of glia cell in the brain, are much more than brain’glue’: Apart from giving structural and metabolic support to neurones, they actively participate in information processing on multiple levels.

We are particularly interested in the special relationship between astrocytes and noradrenergic neurones which constitute a major modulatory system that regulates fundamental brain states and vital functions, such as wakefuleness, attention to important stimuli, motivation, cardiovascular and respiratory activity.

The major questions our lab is currently focussing on are:

  • How does astroglial activity link to release of noradrenaline, and vice versa?
  • Which intracellular second messenger pathways are responsible for modulating release of the relevant glio- and neurotransmitters?
  • What are the physiological consequences of release, for example, for central control of blood pressure, cortical EEG, and behaviour?

We are addressing these questions by using a combination of electrophysiological (patch clamp; amperometry; fast scan cyclic voltammetry), optical (confocal imaging of living brain slice cultures; cell-specific optogenetic stimulation), molecular (viral gene transfer) and pharmacological tools.

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Research Output

  • 39 Article (Academic Journal)
  • 2 Review article (Academic Journal)

Using light for therapy of glioblastoma multiforme (GBM)

Vasilev, A., Sofi, R., Rahman, R., Smith, S. J., Teschemacher, A. G. & Kasparov, S., 31 Jan 2020, In : Brain Sciences. 10, 2, 14 p., 75.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
  • 42 Downloads (Pure)

    Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity

    Sheikhbahaei, S., Turovsky, E. A., Hosford, P. S., Hadjihambi, A., Theparambil, S. M., Liu, B., Marina, N., Teschemacher, A. G., Kasparov, S., Smith, J. C. & Gourine, A. V., 25 Jan 2018, In : Nature Communications. 9, 10 p., 370.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 32 Citations (Scopus)
    271 Downloads (Pure)

    CNS distribution, signalling properties and central effects of G-protein coupled receptor 4

    Hosford, P. S., Mosienko, V., Kishi, K., Jurisic, G., Seuwen, K., Kinzel, B., Ludwig, M. G., Wells, J. A., Christie, I. N., Koolen, L., Abdala, A. P., Liu, B. H., Gourine, A. V., Teschemacher, A. G. & Kasparov, S., Aug 2018, In : Neuropharmacology. 138, p. 381-392 12 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 10 Citations (Scopus)
    255 Downloads (Pure)

    Supervised Work

    Novel molecular tools to selectively inhibit astrocyte-to-neurone L-lactate signalling

    Author: Vaccari Cardoso, B., 28 Nov 2019

    Supervisor: Kasparov, S. (Supervisor) & Teschemacher, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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