Dr Anna L Chambers

MBiochem(Oxon.), PhD(Bristol)

  • BS8 1TD

20032019

Research output per year

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Personal profile

Research interests

In eukaryotes, DNA is packaged into chromatin.  The basic unit of chromatin is the nucleosome, formed by the wrapping of DNA around an octamer of histones proteins.  In order for efficient DNA repair to occur, manipulation of chromatin structure is necessary.   These changes to chromatin organisation include covalent modification of histone proteins, incorporation of histone variants and ATP-dependent chromatin remodelling and defects in these processes can result in genome instability, one of the hallmarks of cancer cells. 

The focus of our research group is in understanding the function of chromatin and ATP-dependent chromatin remodelling complexes in maintenance of genome stability.  We are complementing investigation of the role of chromatin remodellers in mammalian cells with studies in budding yeast and in vitro, biochemical work, in order to elucidate mechanistic detail of how these complexes protect genome integrity. By gaining a more complete understanding of the function of chromatin remodelling in preventing genome instability, we aim to inform treatment strategies and reveal novel drug targets.

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Research Output

  • 16 Article (Academic Journal)
  • 1 Chapter in a book

BAF180 promotes cohesion and prevents genome instability and aneuploidy

Brownlee, P. M., Chambers, A. L., Cloney, R., Bianchi, A. & Downs, J. A., 27 Mar 2014, In : Cell Reports. 6, 6, p. 973-981 9 p.

Research output: Contribution to journalArticle (Academic Journal)

  • 48 Citations (Scopus)

    The BAH domain of Rsc2 is a histone H3 binding domain

    Chambers, A. L., Pearl, L. H., Oliver, A. W. & Downs, J. A., Oct 2013, In : Nucleic Acids Research. 41, 19, p. 9168-82 15 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 14 Citations (Scopus)

    The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres

    Chambers, A. L., Ormerod, G., Durley, S. C., Sing, T. L., Brown, G. W., Kent, N. A. & Downs, J. A., 1 Dec 2012, In : Genes & development. 26, 23, p. 2590-603 14 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 42 Citations (Scopus)

    Activities

    • 1 Fellowship awarded competitively

    Career Development Fellowship - The function of the Irc5 subfamily of chromatin remodelling enzymes in DNA repair.

    Anna L Chambers (Recipient)

    1 Oct 20141 Oct 2017

    Activity: Other activity typesFellowship awarded competitively

    Supervised Work

    Transcription termination by a transcription-repair coupling factor

    Author: Chambers, A. L., 2005

    Supervisor: Savery, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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