Research Output per year
Personal profile
Research interests
In eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of DNA around an octamer of histones proteins. In order for efficient DNA repair to occur, manipulation of chromatin structure is necessary. These changes to chromatin organisation include covalent modification of histone proteins, incorporation of histone variants and ATP-dependent chromatin remodelling and defects in these processes can result in genome instability, one of the hallmarks of cancer cells.
The focus of our research group is in understanding the function of chromatin and ATP-dependent chromatin remodelling complexes in maintenance of genome stability. We are complementing investigation of the role of chromatin remodellers in mammalian cells with studies in budding yeast and in vitro, biochemical work, in order to elucidate mechanistic detail of how these complexes protect genome integrity. By gaining a more complete understanding of the function of chromatin remodelling in preventing genome instability, we aim to inform treatment strategies and reveal novel drug targets.
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Research Output
BAF180 promotes cohesion and prevents genome instability and aneuploidy
Brownlee, P. M., Chambers, A. L., Cloney, R., Bianchi, A. & Downs, J. A., 27 Mar 2014, In : Cell Reports. 6, 6, p. 973-981 9 p.Research output: Contribution to journal › Article (Academic Journal)
The BAH domain of Rsc2 is a histone H3 binding domain
Chambers, A. L., Pearl, L. H., Oliver, A. W. & Downs, J. A., Oct 2013, In : Nucleic Acids Research. 41, 19, p. 9168-82 15 p.Research output: Contribution to journal › Article (Academic Journal)
The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres
Chambers, A. L., Ormerod, G., Durley, S. C., Sing, T. L., Brown, G. W., Kent, N. A. & Downs, J. A., 1 Dec 2012, In : Genes & development. 26, 23, p. 2590-603 14 p.Research output: Contribution to journal › Article (Academic Journal)
Activities
- 1 Fellowship awarded competitively
Career Development Fellowship - The function of the Irc5 subfamily of chromatin remodelling enzymes in DNA repair.
Anna L Chambers (Recipient)
1 Oct 2014 → 1 Oct 2017
Activity: Other activity types › Fellowship awarded competitively
Supervised Work
Transcription termination by a transcription-repair coupling factor
Author: Chambers, A. L., 2005Supervisor: Savery, N. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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