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Personal profile

Research interests

April is a Wellcome Trust-funded PhD student interested in the role of bone mineral density in osteoarthritis pathogenesis and progression. April is co-ordinating follow-up data collection in a unique population of individuals with high bone mass, including X-rays and questionnaire data. April is using this data to determine radiographic OA progression and it's association with high bone mass. April also works on large population-based datatsets (UK Biobank and, through a collaboration with Prof. Joyce van Meurs at Erasmus MC in the Netherlands, the Rotterdam study) to perform genetic and molecular epidemiology analyses (GWAS, Mendelian Randomisation, polygenic risk scores, metabolomics) to identify risk factors for OA and it's progression. 

Prior to her PhD studentship, April completed a BSc in Biology at Imperial College London and then moved to Bristol University to work on the multi-centre VIBE study, investigating the relationship between higher impact physical activity and bone health in older adults. April has been awarded two New Investigator awards from the Bone Research Society and an American Society of Bone and Mineral Research travel grant to attend national and international conferences to present her work. 

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Research Output

  • 14 Article (Academic Journal)

Individuals with High Bone Mass have increased progression of radiographic and clinical features of knee osteoarthritis.

Hartley, A., Hardcastle, S. A., Paternoster, L., McCloskey, E., Poole, K. E. S., Javaid, M. K., Aye, M., Moss, K., Granell, R., Gregory, J., Williams, M., Tobias, J. H. & Gregson, C. L., 27 Mar 2020, (Accepted/In press) In : Osteoarthritis and Cartilage.

Research output: Contribution to journalArticle (Academic Journal)

A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis

Brown, M. A., Hammond, C., Kemp, J. P., Duncan, E. L. & AOGC Consortium, 16 Sep 2019, In : Journal of Bone and Mineral Research. 40 p.

Research output: Contribution to journalArticle (Academic Journal)

  • Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women

    Elhakeem, A., Hartley, A., Luo, Y., Goertzen, A., Hannam, K., Clark, E., Leslie, W. & Tobias, J., 14 Jan 2019, In : Osteoporosis International. 30, 1, p. 211-220 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

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  • 7 Citations (Scopus)
    239 Downloads (Pure)