19972020

Research output per year

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Research Output

  • 57 Article (Academic Journal)
  • 3 Letter (Academic Journal)
  • 1 Review article (Academic Journal)
2020

Expression and retention of thymidine phosphorylase in cultured reticulocytes as a novel treatment for MNGIE

Meinders, M., Shoemark, D. K., Dobbe, J. G. G., Streekstra, G. J., Frayne, J. & Toye, A. M., 12 Jun 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 822-830 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Downloads (Pure)

Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning

Moura, P. L., Dobbe, J. G. G., Streekstra, G. J., Rab, M. A. E., Veldthuis, M., Fermo, E., van Wijk, R., van Zwieten, R., Bianchi, P., Toye, A. M. & Satchwell, T., 19 May 2020, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle (Academic Journal)

2019

Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts

Hampton-O'Neil, L., Severn, C., Gurung, S., Cross, S., Nobes, C. & Toye, A., 13 Jun 2019, In : Haematologica. 104, 8, 36 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Downloads (Pure)

Ex vivo culture of adult CD34+ stem cells using functional highly porous polymer scaffolds to establish biomimicry of the bone marrow niche

Severn, C. E., Eissa, A. M., Langford, C. R., Parker, A., Walker, M., Dobbe, J. G. G., Streekstra, G. J., Cameron, N. R. & Toye, A. M., 1 Dec 2019, In : Biomaterials. 225, 13 p., 119533.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
191 Downloads (Pure)

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Satchwell, T. J., Wright, K. E., Haydn-Smith, K. L., Sánchez-Román Terán, F., Moura, P. L., Hawksworth, J., Frayne, J., Toye, A. M. & Baum, J., 23 Aug 2019, In : Nature Communications. 10, 9 p., 3806 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
104 Downloads (Pure)

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis

Moura, P. L., Hawley, B. R., Dobbe, J. G. G., Streekstra, G. J., Rab, M. A. E., Bianchi, P., van Wijk, R., Toye, A. M. & Satchwell, T., 17 Oct 2019, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
150 Downloads (Pure)

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Moura, P. L., Lizarralde Iragorri, M. A., Francais, O., Le Pioufle, B., Dobbe, J. G. G., Streekstra, G. J., El Nemer, W., Toye, A. M. & Satchwell, T., 10 Sep 2019, In : Blood Advances. 3, 17, p. 2653-2663 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
111 Downloads (Pure)

Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII

Pellegrin, S., Haydn-Smith, K., Hampton-O'Neil, L., Hawley, B., Heesom, K., Fermo, E., Bianchi, P. & Toye, A., 1 Mar 2019, In : British Journal of Haematology. 184, 5, p. 876-881 6 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
1 Citation (Scopus)
191 Downloads (Pure)

Vimentin expression is retained in erythroid cells differentiated from human iPSC and ESC and indicates dysregulation in these cells early in differentiation

Trakarnsanga, T., Ferguson, D., Daniels, D., Griffiths, R., Wilson, M., Mordue, K., Andrienko, T., Condie, A., McCahill, A., Mountford, J. C., Toye, A., Anstee, D. & Frayne, J., 29 Apr 2019, In : Stem Cell Research and Therapy. 10, 10 p., 130.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
151 Downloads (Pure)
2018

Band 3 function and dysfunction in a structural context

Abbas, Y. M., Toye, A. M., Rubinstein, J. L. & Reithmeier, R. A. F., 1 May 2018, In : Current Opinion in Hematology. 25, 3, p. 163-170 8 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
3 Citations (Scopus)
236 Downloads (Pure)

Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Hawksworth, J., Satchwell, T., Meinders, M., Daniels, D., Regan, F., Thornton, N., Wilson, M., Dobbe, J. G. G., Streekstra, G. J., Trakarnsanga, K., Heesom, K., Anstee, D., Frayne, J. & Toye, A., 26 Apr 2018, In : EMBO Molecular Medicine. 10, 5, 11 p., e8454.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
236 Downloads (Pure)

Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages

Heideveld, E., Hampton-O'Neil, L., Cross, S., van Alphen, F. P. J., van den Biggelaar, M., Toye, A. & Van den Akker, E., Mar 2018, In : Haematologica. 103, 3, p. 395-405 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
262 Downloads (Pure)

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

Gurevich, D., Severn, C., Twomey, C., Greenhough, A., Cash, J., Toye, A., Mellor, H. & Martin, P., 2 Jul 2018, In : EMBO Journal. 37, 13, 23 p., e97786.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
27 Citations (Scopus)
308 Downloads (Pure)

Non-muscle Myosin II Drives Vesicle Loss During Human Reticulocyte Maturation

Moura, P. L., Hawley, B., Anstee, D., Satchwell, T. & Toye, A., Dec 2018, In : Haematologica. 103, 12, p. 1997-2007 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
197 Downloads (Pure)

Quantitative measurement of red cell surface protein expression reveals new biomarkers for hereditary spherocytosis

Huisjes, R., Satchwell, T. J., Verhagen, L. P., Schiffelers, R. M., van Solinge, W. W., Toye, A. M. & van Wijk, R., 10 May 2018, In : International Journal of Laboratory Hematology. 4 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
2 Citations (Scopus)
152 Downloads (Pure)

Quantitative proteomics of plasma vesicles identify novel biomarkers for Hemoglobin E/ β-Thalassemic patients

Kittivorapart, J., Karamatic Crew, V., Wilson, M., Heesom, K., Toye, A. & Siritanaratkul, N., Feb 2018, In : Blood Advances. 2, 2, p. 95-104 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
279 Downloads (Pure)
2017

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

Trakarnsanga, K., Griffiths, R. E., Wilson, M. C., Blair, A., Satchwell, T. J., Meinders, M., Cogan, N., Kupzig, S., Kurita, R., Nakamura, Y., Toye, A. M., Anstee, D. J. & Frayne, J., 14 Mar 2017, In : Nature Communications. 8, 7 p., 14750.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
46 Citations (Scopus)
557 Downloads (Pure)

CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex

Mordue, K. E., Hawley, B. R., Satchwell, T. J. & Toye, A. M., 22 May 2017, In : Scientific Reports. 7, 14 p., 2246.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
235 Downloads (Pure)
2016

A new junctional hierarchy

Satchwell, T. & Toye, A., 7 Jul 2016, In : Blood. 128, 1, p. 11-12 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
227 Downloads (Pure)

Comparison of the proteome of adult and cord erythroid cells, and changes in the proteome following reticulocyte maturation

Wilson, M., Trakarnsanga, K., Heesom, K., Toye, A. & Frayne, J., 1 Jun 2016, In : Molecular and Cellular Proteomics. 15, 6, p. 1938-1946 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
46 Citations (Scopus)
327 Downloads (Pure)

Polyurethane scaffolds seeded with CD34+ cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors

Severn, C. E., Macedo, H., Eagle, M., Rooney, P., Mantalaris, A. & Toye, A. M., 30 Aug 2016, In : Scientific Reports. 6, 12 p., 32149.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
305 Downloads (Pure)

Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts

Satchwell, T., Bell, A., Hawley, B., Pellegrin, S., Mordue, K. & Toye, A., 31 Aug 2016, In : Haematologica. 101, 9, p. 1018-1027 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
238 Downloads (Pure)

The European Hematology Association Roadmap For European Hematology Research: A Consensus Document

Engert, A., Mumford, A. D. & Toye, A. M., 1 Feb 2016, In : Haematologica. 101, 2, p. 115-208 95 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
30 Citations (Scopus)
547 Downloads (Pure)
2015

The sorting of blood group active proteins during enucleation

Satchwell, T. J., Bell, A. J. & Toye, A. M., 1 Apr 2015, In : ISBT science series. 10, Suppl 1, p. 163-168 6 p.

Research output: Contribution to journalArticle (Academic Journal)

2014

CFTR potentiators partially restore channel function to A561E, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR

Wang, Y., Liu, J., Loizidou, A., Bugeja, L. A., Warner, R., Hawley, B. R., Cai, Z., Toye, A. M., Sheppard, D. N. & Li, H., 5 Jun 2014, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte

Dasgupta, S., Auth, T., Gov, N. S., Satchwell, T. J., Hanssen, E., Zuccala, E. S., Riglar, D. T., Toye, A. M., Betz, T., Baum, J. & Gompper, G., 1 Jul 2014, In : Biophysical Journal. 107, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS

Trakarnsanga, K., Wilson, M. C., Griffiths, R. E., Toye, A. M., Carpenter, L., Heesom, K. J., Parsons, S. F., Anstee, D. J. & Frayne, J., 2014, In : PLoS ONE. 9, 7, p. e100874

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

The cytoskeletal binding domain of band 3 is required for multiprotein complex formation and retention during erythropoiesis

Satchwell, T. J., Hawley, B. R., Bell, A. J., Ribeiro, M. L. & Toye, A. M., 24 Oct 2014, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2013

Characteristic phenotypes associated with Congenital Dyserythropoietic Anemia (Type II) manifest at different stages of erythropoiesis

Satchwell, T. J., Pellegrin, S., Bianchi, P., Hawley, B. R., Gampel, A., Mordue, K. E., Budnik, A., Fermo, E., Barcellini, W., Stephens, D. J., Van den Akker, E. & Toye, A. M., 9 Aug 2013, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Protein Distribution during Human Erythroblast Enucleation In Vitro

Bell, A. J., Satchwell, T. J., Heesom, K. J., Hawley, B. R., Kupzig, S., Hazell, M., Mushens, R., Herman, A. & Toye, A. M., 2013, In : PLoS ONE. 8, 4, p. e60300

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Relative CO2/NH 3 Permeabilities of Human RhAG, RhBG and RhCG

Geyer, R. R., Parker, M. D., Toye, A. M., Boron, W. F. & Musa-Aziz, R., 29 Sep 2013, In : Journal of Membrane Biology.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)
2012

Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal

Pellegrin, S., Heesom, K. J., Satchwell, T. J., Hawley, B. R., Daniels, G. L., van den Akker, E. & Toye, A. M., Jun 2012, In : PLoS ONE. 7, 6, p. 1-23 23 p., e38356.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Ex-vivo generation of human red cells for transfusion

Anstee, D. J., Gampel, A. & Toye, A. M., 2012, In : Current Opinion in Hematology. 19, 3, p. 163-9 7 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

HCO(3)(-)-independent conductance with a mutant Na(+)/HCO(3)(-) cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalaemic paralysis

Parker, M. D., Qin, X., Williamson, R. C., Toye, A. M. & Boron, W. F., 15 Apr 2012, In : Journal of Physiology. 590, 8, p. 2009-34 26 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)
2011

Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod

Wu, F., Satchwell, T. J. & Toye, A. M., Apr 2011, In : Biochemistry and Cell Biology. 89, 2, p. 106-14 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Critical band 3 multiprotein complex interactions establish early during human erythropoiesis

Satchwell, T. J., Bell, A. J., Pellegrin, S., Kupzig, S., Ridgwell, K., Daniels, G., Anstee, D. J., van den Akker, E. & Toye, A. M., Jul 2011, In : Blood. 118 , 1, p. 182 - 191 10 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Glyceraldehyde 3-phosphate dehydrogenase is required for band 3 (anion exchanger 1) membrane residency in the mammalian kidney

Su, Y., Blake-Palmer, KG., Fry, AC., Best, A., Brown, ACN., Hiemstra, TF., Horita, S., Zhou, A., Toye, AM. & Karet, FE., Jan 2011, In : AJP - Renal Physiology. 300 (1), p. F157 - F166 10 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)
2010

Anion exchanger 1 interacts with nephrin in podocytes

Wu, F., Saleem, M. A., Kampik, N. B., Satchwell, T. J., Williamson, R. C., Blattner, S. M., Ni, L., Toth, T., White, G., Young, M. T., Parker, M. D., Alper, S. L., Wagner, C. A. & Toye, A. M., Sep 2010, In : Journal of the American Society of Nephrology. 21 , 9, p. 1456 - 1467 12 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Band 3 multiprotein complexes in the red cell membrane; of mice and men

van den Akker, E., Satchwell, TJ., Williamson, RC. & Toye, AM., Jun 2010, In : Blood Cells, Molecules and Diseases. 45 (1), p. 1 - 8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (-) cells (Mutations Chatres 1 and 2)

van den Akker, E., Satchwell, T. J., Pellegrin, S., Flatt, J. F., Maigre, M., Daniels, G., Delaunay, J., Bruce, L. J. & Toye, A. M., Aug 2010, In : Haematologica. 95 , 8, p. 1278 - 1286 9 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
76 Citations (Scopus)
2009

Protein 4.2 : A complex linker

Satchwell, TJ., Shoemark, DK., Sessions, RB. & Toye, AM., May 2009, In : Blood Cells, Molecules, and Diseases. 42 (3), p. 201 - 210 10 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels

Brown, ACN., Hallouane, D., Mawby, WJ., Karet, FE., Saleem, MA., Howie, AJ. & Toye, AM., Apr 2009, In : AJP - Renal Physiology. 296, p. 1279 - 1290 12 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
2008

Band 3 courcouronnes (Ser667Phe): a trafficking mutant differentially rescued by wild-type band 3 and glycophorin A

Toye, A. M., Williamson, R. C., Khanfar, M., Bader-Meunier, B., Cynober, T., Thibault, M., Tchernia, G., Déchaux, M., Delaunay, J. & Bruce, L. J., Jun 2008, In : Blood. 111 , 11, p. 5380 - 5389 10 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Glycophorin A: Band 3 aid

Williamson, RC. & Toye, AM., Jul 2008, In : Blood Cells, Molecules, and Diseases. 41 (1), p. 35 - 43 9 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Human kidney anion exchanger 1 localisation in MDCK cells is controlled by the phosphorylation status of two critical tyrosines

Williamson, RC., Brown, ACN., Mawby, WJ. & Toye, AM., Oct 2008, In : Journal of Cell Science. 121 (20), p. 3422 - 3432 11 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)
2007

Immunohistochemical comparison of a case of inherited distal renal tubular acidosis (with a unique AE1 mutation) with an acquired case secondary to autoimmune disease

Walsh, S., Turner, CM., Toye, A., Wagner, C., Jaeger, P., Laing, C. & Unwin, R., Mar 2007, In : Nephrology Dialysis Transplantation. 22 (3), p. 807 - 812 6 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Opsin stability and folding: The role of Cys185 and abnormal disulfide bond formation in the intradiscal domain

Mckibbin, C., Toye, AM., Reeves, PJ., Gobind Khorana, H., Edwards, PC., Villa, C. & Booth, PJ., Dec 2007, In : Journal of Molecular Biology. 374 (5), p. 1309 - 1318 10 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2006

The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia

Toye, A. M., Parker, M. D., Daly, C. M., Lu, J., Virkki, L. V., Pelletier, M. F. & Boron, W. F., May 2006, In : AJP - Cell Physiology. 291, 4, p. C788 - C801 14 p.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)
2005

Defective kidney anion-exchanger I (AEI, Band 3) trafficking in dominant distal renal tubular acidosis (dRTA)

Toye, AM., 2005, In : Biochemical Society Symposia. 72, p. 47 - 63 17 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)