Projects per year
Professor Ashley Blom is the Head of the Medical School, an NIHR Senior Investigator and a Fellow of the Academy of Medical Sciences.
He leads the analysis team of the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR), which is the largest registry of joint replacements in the world. In addition to NJR research into the outcomes of arthroplasty, he leads major NIHR funded programmes into treating infection after arthroplasty; improving the patient experience of joint replacement; first-in-human studies of meniscal repair (including stem cell therapy) and biofunctionalisation of titanium. He leads the Orthopaedic workstreams into Surgical Innovation in the University of Bristol Biomedical Research Centre.
Ashley is past President of the European Orthopaedic Research Society and is member of both the Education and Specialist Societies Committees of the European Federation of National Associations of Orthopaedics and Traumatology.
Activities / Findings
Ashley and the team in the Musculoskeletal Research Unit have published seminal work on the safety and efficacy of Orthopaedic implants. This work includes papers published in the Lancet showing the high failure rates of metal-on-metal and resurfacing hip replacements and showing which factors are associated with decreasing mortality after hip and knee replacement. The team are currently undertaking a large body of research into infection and have published work showing which factors are associated with an increased risk of infection after joint replacement. Ongoing work includes a multinational trial of one versus two stage revision for infected hip replacements and analysis of the NJR to determine the relative efficacy of different treatment strategies for infection after hip and knee replacement.
The team have recently completed a first-in-human study using stem cells to heal meniscal tears in the knee.
Ashley is an orthopaedic surgeon specialising in hip replacements. He leads large programmes of research into various aspects of arthroplasty including outcomes, adverse occurrence, development of novel treatments and provision of care. These programmes utilise a range of methodologies including evidence synthesis, bone biology, biomaterials, first-in-human trials, multicentre RCTs, analysis of routine datasets, qualitative research and health economics.
Failure rates of metal-on-metal hip resurfacings: analysis of data from the National Joint Registry for England and WalesSmith, A. J., Dieppe, P., Howard, P. W., Blom, A. W. & on behalf of the National Joint Registry for England and Wales, Nov 2012, In: Lancet. 380, 9855, p. 1759-1766
Research output: Contribution to journal › Article (Academic Journal) › peer-review195 Citations (Scopus)
Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the National Joint Registry of England and WalesSmith, A., Dieppe, P., Vernon, KC., Porter, M. & Blom, AW., Mar 2012, In: Lancet. 379, 9822, p. 1199-1204 5 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review393 Citations (Scopus)
Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statisticsSmith, A., Dieppe, P., Porter, M. & Blom, AW., 2012, In: BMJ. 344, e2383.
Research output: Contribution to journal › Article (Academic Journal) › peer-review131 Citations (Scopus)