Professor Astrid C E Linthorst

Search results

• 2019

  Continuous Free Cortisol Profiles - Circadian Rhythms in Healthy Men

  Bhake, R. C., Kluckner, V., Stassen, H., Russell, G. M., Leendertz, J., Stevens, K., Linthorst, A. C. E. & Lightman, S. L., Dec 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 5935-5947 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hydrocortisone 85%
  • Lunch 17%
  • Experiments 10%
  • Serum 6%
  19 Citations (Scopus)

  64 Downloads (Pure)

• Continuous Free Cortisol Profiles in Healthy Men - Validation of Microdialysis Method

  Bhake, R., Russell, G. M., Kershaw, Y., Stevens, K., Zaccardi, F., Warburton, V. E. C., Linthorst, A. C. E. & Lightman, S. L., 16 Sep 2019, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism. 105, 4, p. e1749-e1761 dgz002.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hydrocortisone 100%
  • Cortisol 100%
  • Man 60%
  • Microdialysis 40%
  • Blood 30%
  12 Citations (Scopus)

  135 Downloads (Pure)
• 2016

  Epigenetics of Glucocorticoid Action

  Mifsud, K. R., Carter, S. D., Linthorst, A. C. E. & Reul, J. M. H. M., 10 Jun 2016, (Accepted/In press) Hormones, Brain, and Behavior, Third Edition. Pfaff, D. & Joëls, M. (eds.). 3 ed. Amsterdam:Elsevier

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  • Glucocorticoid 100%
  • Epigenetic Mechanism 74%
  • Protocerebrum 37%
  • Glucocorticoid Receptor 25%
  • Mineralocorticoid Receptor 25%

• Potential pleiotropic beneficial effects of adjuvant melatonergic treatment in posttraumatic stress disorder

  Agorastos, A. & Linthorst, A. C. E., Aug 2016, In: Journal of Pineal Research. 61, 1, p. 3-26 24 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Posttraumatic Stress Disorder 100%
  • Stress-Related Disorders 69%
  • Therapeutic Procedure 40%
  • Treatment 40%
  • Pathophysiology 30%
  31 Citations (Scopus)

  492 Downloads (Pure)
• 2015

  Association of Body Mass Index with Depression, Anxiety and Suicide-An Instrumental Variable Analysis of the HUNT Study

  Bjørngaard, J. H., Carslake, D., Lund Nilsen, T. I., Linthorst, A. C. E., Davey Smith, G., Gunnell, D. & Romundstad, P. R., 2015, In: PLoS ONE. 10, 7, p. e0131708

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Anxiety 100%
  • Child 51%
  • Body Mass Index 51%
  • Depression 33%
  • Suicide 29%
  29 Citations (Scopus)

  5 Downloads (Pure)

• Glucocorticoids, epigenetic control and stress resilience

  Reul, J. M. H. M., Collins, A., Saliba, R., Mifsud, K. R., Carter, S., Gutierrez Mecinas, M., Qian, X. & Linthorst, A. C. E., 2015, In: Neurobiology of Stress. 1, 1, p. 44-59 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glucocorticoid 100%
  • Stress 83%
  • Resilience 66%
  • Exercise 33%
  • Epigenetics 33%
  81 Citations (Scopus)
• 2013

  A functional role for both GABA transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus

  Kersanté, F., Rowley, S. C. S., Pavlov, I., Gutierrez Mecinas, M., Semyanov, A., Reul, J. M. H. M., Walker, M. C. & Linthorst, A. C. E., 15 May 2013, In: Journal of Physiology. 591, 10, p. 2429-2441 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Gamma-Aminobutyric Acid 100%
  • GABA Transporter 3 72%
  • GABA Transporter 1 63%
  • Hippocampus 27%
  • Conductance 27%
  102 Citations (Scopus)

  383 Downloads (Pure)

• Automated 24-hours sampling of subcutaneous tissue free cortisol in humans

  Bhake, R. C., Leendertz, J. A., Linthorst, A. C. E. & Lightman, S. L., Apr 2013, In: Journal of Medical Engineering and Technology. 37, 3, p. 180-4 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Sampling 100%
  • Hormone 100%
  • Sample 66%
  • Microdialysis 66%
  • Ultradian Rhythm 66%
  39 Citations (Scopus)

• GABA-independent GABAA receptor openings maintain tonic currents

  Wlodarczyk, A. I., Sylantyev, S., Herd, M. B., Kersanté, F., Lambert, J. J., Rusakov, D. A., Linthorst, A. C. E., Semyanov, A., Belelli, D., Pavlov, I. & Walker, M. C., 27 Feb 2013, In: Journal of Neuroscience. 33, 9, p. 3905-3914 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Gamma-Aminobutyric Acid 100%
  • 4 Aminobutyric Acid Receptor 100%
  • GABA Receptor 100%
  • Granule Cell 57%
  • Hippocampus 42%
  74 Citations (Scopus)

  456 Downloads (Pure)
• 2012

  Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain

  Qian, X., Droste, S. K., Lightman, S. L., Reul, J. M. H. M. & Linthorst, A. C. E., Sep 2012, In: Endocrinology. 153, 9, p. 4346-4353 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Rhythms 100%
  • Blood Product 72%
  • Corticosterone 54%
  • Ultradian Rhythm 45%
  • Rhythm 45%
  91 Citations (Scopus)

  529 Downloads (Pure)
• 2011

  A Rapid Release of Corticosteroid-Binding Globulin from the Liver Restrains the Glucocorticoid Hormone Response to Acute Stress

  Qian, X., Droste, SK., Gutièrrez-Mecinas, M., Collins, A., Kersanté, F., Reul, JMHM. & Linthorst, ACE., Oct 2011, In: Endocrinology. 152, 10, p. 3738 - 3748 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Transcortin 100%
  • Glucocorticoid 75%
  • Stress 75%
  • Corticosterone 50%
  • Clotiazepam 37%
  80 Citations (Scopus)

  527 Downloads (Pure)
• 2010

  The impact of stress on serotonergic neurotransmission

  Linthorst, ACE. & Reul, JMHM., 2010, Handbook of Behavioral Neurobiology of Serotonin. Müller, CP. & Jacobs, BL. (eds.). Academic Press, p. 475 - 491

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  6 Citations (Scopus)

• Voluntary exercise alters GABAA receptor subunit and glutamic acid decarboxylase-67 gene expression in the rat forebrain

  Hill, LE., Droste, S-K., Nutt, DJ., Linthorst, ACE. & Reul, JMHM., 2010, In: Journal of Psychopharmacology. 24, p. 745 - 756

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  44 Citations (Scopus)
• 2009

  Distinct, time-dependent effects of voluntary exercise on circadian and ultradian rhythms and stress responses of free corticosterone in the rat hippocampus

  Droste, S-K., Collins, A., Lightman, SL., Linthorst, ACE. & Reul, JMHM., 1 Sep 2009, In: Endocrinology. 150, 9, p. 4170 - 4179 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Rat 100%
  • Rats 100%
  • Exercise 85%
  • Corticosterone 85%
  • Glucocorticoid 57%
  56 Citations (Scopus)

• The ultradian and circadian rhythms of free corticosterone in the brain are not affected by gender: an in vivo microdialysis study in Wistar rats

  Droste, S-K., de Groote, L., Lightman, SL., Reul, JMHM. & Linthorst, ACE., 2009, In: Journal of Neuroendocrinology. 21, p. 132 - 140

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  54 Citations (Scopus)
• 2008

  Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress

  Droste, S-K., de Groote, L., Atkinson, HC., Lightman, SL., Reul, JMHM. & Linthorst, ACE., 1 Jul 2008, In: Endocrinology. 149, 7, p. 3244 - 3253 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Ultradian Rhythm 100%
  • Rhythms 100%
  • Blood Brain Barrier 25%
  • Tissue Reaction 25%
  • Adrenal Cortex 25%
  225 Citations (Scopus)

• Stress and the brain: Solving the puzzle using microdialysis

  Linthorst, ACE. & Reul, JMHM., 2008, In: Pharmacology, Biochemistry and Behavior. 90, p. 163 - 173

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Serotonin 100%
  • Gamma-Aminobutyric Acid 83%
  • Microdialysis 83%
  • 4 Aminobutyric Acid 83%
  • Benzodiazepine 66%
  84 Citations (Scopus)

• Water temperature determines neurochemical and behavioural responses to forced swim stress: an in vivo microdialysis and biotelemetry study in rats

  Linthorst, ACE., Flachskamm, C. & Reul, JMHM., Apr 2008, In: Stress. 11, p. 88 - 100 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Temperature 100%
  • 5-Hydroxyindoleacetic Acid 83%
  • Behavior (Neuroscience) 66%
  • Behavior 66%
  • Core Temperature 66%
  46 Citations (Scopus)
• 2007

  Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampus

  de Groote, L. & Linthorst, ACE., Sep 2007, In: Neuroscience. 148 (3), p. 794 - 805 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Gamma-Aminobutyric Acid 100%
  • Inhibition 45%
  • Stressors 36%
  • Rats 27%
  • Neuronal Activity 27%
  88 Citations (Scopus)

• Microdialysis to study the effects of stress on serotonin, corticosterone and behaviour

  Linthorst, ACE., 2007, Handbook of microdialysis: methods, applications and clinical aspects. Westerink, BHC. & Cremers, TIFH. (eds.). Amsterdam:Elsevier, p. 301 - 315 15 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

• Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level

  Droste, S-K., Chandramohan, Y., Hill, LE., Linthorst, ACE. & Reul, JMHM., Aug 2007, In: Neuroendocrinology. 86 (1), p. 26 - 37 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Hormone Response 100%
  • Glucocorticoid Receptor 100%
  • Body Weight Gain 50%
  • Corticotropin Blood Level 50%
  • Sprague Dawley Rat 50%
  134 Citations (Scopus)
• 2005

  Differential monoaminergic, neuroendocrine and behavioural responses after central administration of corticotropin-releasing factor receptor type 1 and type 2 agonists

  de Groote, L., Peñalva, RG., Flachskamm, C., Reul, JMHM. & Linthorst, ACE., Jul 2005, In: Journal of Neurochemistry. 94 (1), p. 45 - 56 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  77 Citations (Scopus)

• Effects of exposure to a predator on behaviour and serotonergic neurotransmission in different brain regions of C57BL/6N mice

  Beekman, M., Flachskamm, C. & Linthorst, ACE., May 2005, In: European Journal of Neuroscience. 21 (10), p. 2825 - 2836 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  43 Citations (Scopus)

• Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders

  Linthorst, ACE., 2005, The handbook of experimental pharmacology: Anxiety and anxiolytic drugs. Holsboer, F. & Strohle, A. (eds.). Springer Berlin Heidelberg, Vol. 169. p. 181 - 204 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  35 Citations (Scopus)

• Stress, corticotropin-releasing factor and serotonergic neurotransmission

  Linthorst, ACE., 2005, Handbook of stress and the brain, Part 1: The neurobiology of Stress. Steckler, T., Kalin, NH. & Reul, JMHM. (eds.). Amsterdam:Elsevier, Vol. 15. p. 503 - 524 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  13 Citations (Scopus)

• The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects cAMP-responsive element-binding protein phosphorylation in rat brain

  Bachmann, C. G., Bilang-Bleuel, A., De Carli, S., Linthorst, A. C. E. & Reul, J. M. H. M., 20 Jun 2005, In: Neuroendocrinology. 81, 2, p. 129-36 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cyclic Adenosine Monophosphate 100%
  • Binding Protein 50%
  • Forced Swim Test 50%
  • Element 50%
  • Protein Binding 50%

• The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects CREB phosphorylation in rat brain

  Bachmann, CG., Bilang-Bleuel, A., De Carli, S., Linthorst, ACE. & Reul, JMHM., 2005, In: Neuroendocrinology. 81, p. 129 - 136 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
• 2003

  Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775

  Oshima, A., Flachskamm, C., Reul, JMHM., Holsboer, F. & Linthorst, ACE., Dec 2003, In: Neuropsychopharmacology. 28 (12), p. 2148 - 2159 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  62 Citations (Scopus)

• Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis

  Bachmann, C., Linthorst, ACE., Holsboer, F. & Reul, JMHM., 2003, In: Neuropsychopharmacology. 28, p. 1056 - 1067 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  63 Citations (Scopus)

• Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats

  Peñalva, RG., Lancel, M., Flachskamm, C., Reul, JMHM., Holsboer, F. & Linthorst, ACE., May 2003, In: European Journal of Neuroscience. 17 (9), p. 1896 - 1906 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  72 Citations (Scopus)

• Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis

  Droste, S-K., Gesing, A., Ulbricht, S., Müller, MB., Linthorst, ACE. & Reul, JMHM., Jul 2003, In: Endocrinology. 144 (7), p. 3012 - 3023 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  273 Citations (Scopus)

• The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

  Cota, D., Marsicano, G., Tschop, M., Grubler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thone-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, ACE., Pasquali, R., Lutz, B., Stalla, GK. & Pagotto, U., 2003, In: Journal of Clinical Investigation. 112, p. 423 - 431 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
• 2002

  Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice

  Peñalva, RG., Flachskamm, C., Zimmermann, S., Wurst, W., Holsboer, F., Reul, JMHM. & Linthorst, ACE., Jan 2002, In: Neuroscience. 109 (2), p. 253 - 266 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  64 Citations (Scopus)

• Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism

  Linthorst, ACE., Peñalva, RG., Flachskamm, C., Holsboer, F. & Reul, JMHM., Dec 2002, In: European Journal of Neuroscience. 16 (12), p. 2441 - 2452 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  115 Citations (Scopus)
• 2001

  Bidirectional effects of corticosterone on splenic T-cell activation: critical role of cell density and culture time

  Wiegers, GJ., Stec, IE., Klinkert, WE., Linthorst, ACE. & Reul, JMHM., 2001, In: Neuroendocrinology. 73, p. 139 - 148

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  14 Citations (Scopus)

• Liquoruntersuchungen

  Bronisch, T., Brunner, J. & Linthorst, A. C. E., 2001, Neurobiologie suizidalen Verhaltens (Bronisch T, Felber W, Wolfersdorf M, eds). pp 145-160. Regensburg: Roderer. . Bronisch, T., Felber, W. & Wolfersdorf, M. (eds.). Regensburg: Roderer, p. 145-160

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

• Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone

  Gesing, A., Bilang-Bleuel, A., Droste, SK., Linthorst, ACE., Holsboer, F. & Reul, JMHM., 1 Jul 2001, In: Journal of Neuroscience. 21 (13), p. 4822 - 4829 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  189 Citations (Scopus)
• 2000

  Diurnal variations in lipopolysaccharide-induced sleep, sickness behavior and changes in corticosterone levels in the rat

  Mathias, S., Schiffelholz, T., Linthorst, A. C., Pollmächer, T. & Lancel, M., Jun 2000, In: Neuroendocrinology. 71, 6, p. 375-85 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Lipopolysaccharide 100%
  • Sleep 71%
  • Behavior 42%
  • Rats 42%
  • Temperature 42%

• Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice

  Linthorst, A. C., Flachskamm, C., Barden, N., Holsboer, F. & Reul, J. M., Jan 2000, In: European Journal of Neuroscience. 12, 1, p. 283-91 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mice 100%
  • Glucocorticoid Receptor 83%
  • Mouse 75%
  • Probe 75%
  • Rat 41%
  96 Citations (Scopus)

• New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders

  Reul, J. M., Bilang-Bleuel, A., Droste, S., Linthorst, A. C., Holsboer, F. & Gesing, A., 2000, In: Zeitschrift für Rheumatologie. 59 Suppl 2, p. II/22-5

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mineralocorticoid Receptor 100%
  • Stress-Related Disorders 80%
  • Regulatory Mechanism 60%
  • Receptor Binding 40%
  • Comprehension 20%
  15 Citations (Scopus)

• Responses in the raphe-hippocampal serotonergic system during peripheral inflammation: putative role in sickness behaviour

  Reul, J. M. H. M. & Linthorst, A. C. E., 2000, Research and perspectives in neurosciences: Neuro-immune interactions in neurologic and psychiatric disorders. Patterson, P., Kordon, C. & Christen, Y. (eds.). Springer Berlin Heidelberg, p. 89-109

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

• The brain mineralocorticoid receptor: greedy for ligand, mysterious in function

  Reul, J. M., Gesing, A., Droste, S., Stec, I. S., Weber, A., Bachmann, C., Bilang-Bleuel, A., Holsboer, F. & Linthorst, A. C., 29 Sep 2000, In: European Journal of Pharmacology: Molecular Pharmacology. 405, 1-3, p. 235-49 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mineralocorticoid Receptor 100%
  • Hippocampus 50%
  • Glucocorticoid Receptor 41%
  • Brain 33%
  • Protocerebrum 33%
  191 Citations (Scopus)

• Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats

  Hölter, S. M., Linthorst, A. C., Reul, J. M. & Spanagel, R., May 2000, In: Pharmacology, Biochemistry and Behavior. 66, 1, p. 143-51 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Alcohol 100%
  • Deprivation 64%
  • Groups 47%
  • Alcohol Abuse 47%
  • Intake 17%
  42 Citations (Scopus)
• 1999

  Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin

  Linthorst, A. C., Karanth, S., Barden, N., Holsboer, F. & Reul, J. M. H. M., Jan 1999, In: European Journal of Neuroscience. 11, 1, p. 178-86 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mouse 100%
  • Glucocorticoid Receptor 83%
  • Endotoxin 66%
  • Body Temperature 50%
  • Locomotion 16%
  19 Citations (Scopus)

• Inflammation and brain function under basal conditions and during long-term elevation of brain corticotropin-releasing hormone levels

  Linthorst, A. C. & Reul, J. M., 1999, In: Advances in Experimental Medicine and Biology. 461, p. 129-52 24 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  27 Citations (Scopus)
• 1998

  Altered neuroimmunoendocrine communication during a condition of chronically increased brain corticotropin-releasing hormone drive

  Reul, J. M., Labeur, M. S., Wiegers, G. J. & Linthorst, A. C., 1 May 1998, In: Annals of the New York Academy of Sciences. 840, p. 444-55 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Corticotropin Releasing Factor 100%
  • Corticotropin-Releasing Hormone 100%
  • Immune System 57%
  • Stress-Related Disorders 57%
  • Brain 42%
  26 Citations (Scopus)

• Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior

  Liebsch, G., Linthorst, A. C., Neumann, I. D., Reul, J. M., Holsboer, F. & Landgraf, R., Nov 1998, In: Neuropsychopharmacology. 19, 5, p. 381-96 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Anxiety 100%
  • Behavior 80%
  • Behavior (Neuroscience) 66%
  • Rats 46%
  • Rat 33%
  138 Citations (Scopus)

• Brain neurotransmission during peripheral inflammation

  Linthorst, A. C. & Reul, J. M., 1 May 1998, In: Annals of the New York Academy of Sciences. 840, p. 139-52 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Noradrenalin 100%
  • Neurotransmitter 100%
  • Neurotransmission 100%
  • Noradrenaline 100%
  • Serotonin 66%
  72 Citations (Scopus)

• Tumour necrosis factor-alpha and interleukin-2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic-pituitary-adrenocortical axis activity in the rat

  Pauli, S., Linthorst, A. C. & Reul, J. M., Mar 1998, In: European Journal of Neuroscience. 10, 3, p. 868-78 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Interleukin 2 100%
  • Neurotransmission 100%
  • Serotonergic 83%
  • Serotonin 83%
  • Body Temperature 83%
  64 Citations (Scopus)
• 1997

  Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function

  Karanth, S., Linthorst, A. C., Stalla, G. K., Barden, N., Holsboer, F. & Reul, J. M., Aug 1997, In: Endocrinology. 138, 8, p. 3476-85 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Transgenic Mouse 100%
  • Corticosterone 66%
  • Corticotropin 66%
  • Corticotropin Release 66%
  • Tissues 55%
  80 Citations (Scopus)