Professor Astrid C E Linthorst

Search results

• 2019

  Continuous Free Cortisol Profiles - Circadian Rhythms in Healthy Men

  Bhake, R. C., Kluckner, V., Stassen, H., Russell, G. M., Leendertz, J., Stevens, K., Linthorst, A. C. E. & Lightman, S. L., Dec 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 5935-5947 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hydrocortisone 85%
  • Lunch 17%
  • Experiments 10%
  • Serum 6%
  37 Citations (Scopus)

  161 Downloads (Pure)

• Continuous Free Cortisol Profiles in Healthy Men - Validation of Microdialysis Method

  Bhake, R., Russell, G. M., Kershaw, Y., Stevens, K., Zaccardi, F., Warburton, V. E. C., Linthorst, A. C. E. & Lightman, S. L., 16 Sept 2019, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism. 105, 4, p. e1749-e1761 dgz002.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Microdialysis 100%
  • Hydrocortisone 100%
  • Cortisol 100%
  • Dexamethasone 30%
  • Tetracosactide 25%
  26 Citations (Scopus)

  190 Downloads (Pure)
• 2016

  Potential pleiotropic beneficial effects of adjuvant melatonergic treatment in posttraumatic stress disorder

  Agorastos, A. & Linthorst, A. C. E., Aug 2016, In: Journal of Pineal Research. 61, 1, p. 3-26 24 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Posttraumatic Stress Disorder 100%
  • Stress-Related Disorders 30%
  • Melatonin 10%
  • Neuroendocrine System 10%
  • Epigenetics 10%
  36 Citations (Scopus)

  596 Downloads (Pure)
• 2015

  Association of Body Mass Index with Depression, Anxiety and Suicide-An Instrumental Variable Analysis of the HUNT Study

  Bjørngaard, J. H., Carslake, D., Lund Nilsen, T. I., Linthorst, A. C. E., Davey Smith, G., Gunnell, D. & Romundstad, P. R., 2015, In: PLoS ONE. 10, 7, p. e0131708

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Body Mass 100%
  • Instrumental Variable Analysis 100%
  • Body Mass Index 100%
  • Child 50%
  • Offspring 50%
  35 Citations (Scopus)

  5 Downloads (Pure)

• Glucocorticoids, epigenetic control and stress resilience

  Reul, J. M. H. M., Collins, A., Saliba, R., Mifsud, K. R., Carter, S., Gutierrez Mecinas, M., Qian, X. & Linthorst, A. C. E., 2015, In: Neurobiology of Stress. 1, 1, p. 44-59 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Epigenetics 100%
  • Glucocorticoid 100%
  • Signal Transduction 11%
  • Single-Nucleotide Polymorphism 11%
  • Secretion (Process) 11%
  101 Citations (Scopus)
• 2013

  A functional role for both GABA transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus

  Kersanté, F., Rowley, S. C. S., Pavlov, I., Gutierrez Mecinas, M., Semyanov, A., Reul, J. M. H. M., Walker, M. C. & Linthorst, A. C. E., 15 May 2013, In: Journal of Physiology. 591, 10, p. 2429-2441 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hippocampus 100%
  • GABA Transporter 3 100%
  • Gamma-Aminobutyric Acid 100%
  • GABA Transporter 1 100%
  • In Vivo 27%
  115 Citations (Scopus)

  446 Downloads (Pure)

• Automated 24-hours sampling of subcutaneous tissue free cortisol in humans

  Bhake, R. C., Leendertz, J. A., Linthorst, A. C. E. & Lightman, S. L., Apr 2013, In: Journal of Medical Engineering and Technology. 37, 3, p. 180-4 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Circadian Rhythm 100%
  • Microdialysis 100%
  • Ultradian Rhythm 100%
  • Cortisol 100%
  • Superficial Fascia 100%
  47 Citations (Scopus)

• GABA-independent GABAA receptor openings maintain tonic currents

  Wlodarczyk, A. I., Sylantyev, S., Herd, M. B., Kersanté, F., Lambert, J. J., Rusakov, D. A., Linthorst, A. C. E., Semyanov, A., Belelli, D., Pavlov, I. & Walker, M. C., 27 Feb 2013, In: Journal of Neuroscience. 33, 9, p. 3905-3914 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • GABA Receptor 100%
  • GABAA Receptor 100%
  • Gamma-Aminobutyric Acid 100%
  • Granule Cell 50%
  • In Vivo 12%
  82 Citations (Scopus)

  522 Downloads (Pure)
• 2012

  Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain

  Qian, X., Droste, S. K., Lightman, S. L., Reul, J. M. H. M. & Linthorst, A. C. E., Sept 2012, In: Endocrinology. 153, 9, p. 4346-4353 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Circadian Rhythm 100%
  • Ultradian Rhythm 100%
  • Glucocorticoid 100%
  • Superficial Fascia 100%
  • Corticosterone 100%
  99 Citations (Scopus)

  578 Downloads (Pure)
• 2011

  A Rapid Release of Corticosteroid-Binding Globulin from the Liver Restrains the Glucocorticoid Hormone Response to Acute Stress

  Qian, X., Droste, S., Gutièrrez-Mecinas, M., Collins, A., Kersanté, F., Reul, J. & Linthorst, A., Oct 2011, In: Endocrinology. 152, 10, p. 3738 - 3748 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hormone Response 100%
  • Transcortin 100%
  • Acute Stress 100%
  • Glucocorticoid 100%
  • Corticosterone 66%
  85 Citations (Scopus)

  697 Downloads (Pure)
• 2010

  Voluntary exercise alters GABAA receptor subunit and glutamic acid decarboxylase-67 gene expression in the rat forebrain

  Hill, L., Droste, S.-K., Nutt, D., Linthorst, A. & Reul, J., 2010, In: Journal of Psychopharmacology. 24, p. 745 - 756

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  46 Citations (Scopus)
• 2009

  Distinct, time-dependent effects of voluntary exercise on circadian and ultradian rhythms and stress responses of free corticosterone in the rat hippocampus

  Droste, S.-K., Collins, A., Lightman, S., Linthorst, A. & Reul, J., 1 Sept 2009, In: Endocrinology. 150, 9, p. 4170 - 4179 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Corticosterone 100%
  • Hippocampus 100%
  • Ultradian Rhythms 100%
  • Ultradian 33%
  • Glucocorticoid 33%
  57 Citations (Scopus)

• The ultradian and circadian rhythms of free corticosterone in the brain are not affected by gender: an in vivo microdialysis study in Wistar rats

  Droste, S.-K., de Groote, L., Lightman, S., Reul, J. & Linthorst, A., 2009, In: Journal of Neuroendocrinology. 21, p. 132 - 140

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  57 Citations (Scopus)
• 2008

  Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress

  Droste, S.-K., de Groote, L., Atkinson, H., Lightman, S., Reul, J. & Linthorst, A., 1 Jul 2008, In: Endocrinology. 149, 7, p. 3244 - 3253 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Corticosterone 100%
  • Ultradian Rhythms 100%
  • Blood Plasma 41%
  • Glucocorticoid 25%
  • In Vivo 8%
  245 Citations (Scopus)

• Stress and the brain: Solving the puzzle using microdialysis

  Linthorst, A. & Reul, J., 2008, In: Pharmacology, Biochemistry and Behavior. 90, p. 163 - 173

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Serotonin 100%
  • Gamma-Aminobutyric Acid 100%
  • Microdialysis 100%
  • Hippocampus 40%
  • Behavior (Neuroscience) 20%
  88 Citations (Scopus)

• Water temperature determines neurochemical and behavioural responses to forced swim stress: an in vivo microdialysis and biotelemetry study in rats

  Linthorst, A., Flachskamm, C. & Reul, J., Apr 2008, In: Stress. 11, p. 88 - 100 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Microdialysis 100%
  • Neurochemical 100%
  • Water Temperature 100%
  • In Vivo 100%
  • 5-Hydroxyindoleacetic Acid 100%
  50 Citations (Scopus)
• 2007

  Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampus

  de Groote, L. & Linthorst, A., Sept 2007, In: Neuroscience. 148 (3), p. 794 - 805 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Hippocampus 100%
  • Gamma-Aminobutyric Acid 100%
  • Reuptake 20%
  • In Vivo 10%
  • Neurotransmitter 10%
  91 Citations (Scopus)

• Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level

  Droste, S.-K., Chandramohan, Y., Hill, L., Linthorst, A. & Reul, J., Aug 2007, In: Neuroendocrinology. 86 (1), p. 26 - 37 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Messenger RNA 100%
  • Corticosterone 80%
  • Adrenocorticotropic Hormone 60%
  • Glucocorticoid 60%
  • Glucocorticoid Receptor 40%
  141 Citations (Scopus)
• 2005

  Differential monoaminergic, neuroendocrine and behavioural responses after central administration of corticotropin-releasing factor receptor type 1 and type 2 agonists

  de Groote, L., Peñalva, R., Flachskamm, C., Reul, J. & Linthorst, A., Jul 2005, In: Journal of Neurochemistry. 94 (1), p. 45 - 56 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  80 Citations (Scopus)

• Effects of exposure to a predator on behaviour and serotonergic neurotransmission in different brain regions of C57BL/6N mice

  Beekman, M., Flachskamm, C. & Linthorst, A., May 2005, In: European Journal of Neuroscience. 21 (10), p. 2825 - 2836 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  43 Citations (Scopus)

• The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects cAMP-responsive element-binding protein phosphorylation in rat brain

  Bachmann, C. G., Bilang-Bleuel, A., De Carli, S., Linthorst, A. C. E. & Reul, J. M. H. M., 20 Jun 2005, In: Neuroendocrinology. 81, 2, p. 129-36 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Binding Protein 100%
  • Protein Phosphorylation 100%
  • Forced Swim Test 100%
  • Cyclic Adenosine Monophosphate 100%
  • Glucocorticoid Receptor 100%
  23 Citations (Scopus)

• The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects CREB phosphorylation in rat brain

  Bachmann, C., Bilang-Bleuel, A., De Carli, S., Linthorst, A. & Reul, J., 2005, In: Neuroendocrinology. 81, p. 129 - 136 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
• 2003

  Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775

  Oshima, A., Flachskamm, C., Reul, J., Holsboer, F. & Linthorst, A., Dec 2003, In: Neuropsychopharmacology. 28 (12), p. 2148 - 2159 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  62 Citations (Scopus)

• Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis

  Bachmann, C., Linthorst, A., Holsboer, F. & Reul, J., 2003, In: Neuropsychopharmacology. 28, p. 1056 - 1067 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  66 Citations (Scopus)

• Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats

  Peñalva, R., Lancel, M., Flachskamm, C., Reul, J., Holsboer, F. & Linthorst, A., May 2003, In: European Journal of Neuroscience. 17 (9), p. 1896 - 1906 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  75 Citations (Scopus)

• Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis

  Droste, S.-K., Gesing, A., Ulbricht, S., Müller, M., Linthorst, A. & Reul, J., Jul 2003, In: Endocrinology. 144 (7), p. 3012 - 3023 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  290 Citations (Scopus)

• The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

  Cota, D., Marsicano, G., Tschop, M., Grubler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thone-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A., Pasquali, R., Lutz, B., Stalla, G. & Pagotto, U., 2003, In: Journal of Clinical Investigation. 112, p. 423 - 431 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
• 2002

  Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice

  Peñalva, R., Flachskamm, C., Zimmermann, S., Wurst, W., Holsboer, F., Reul, J. & Linthorst, A., Jan 2002, In: Neuroscience. 109 (2), p. 253 - 266 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  65 Citations (Scopus)

• Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism

  Linthorst, A., Peñalva, R., Flachskamm, C., Holsboer, F. & Reul, J., Dec 2002, In: European Journal of Neuroscience. 16 (12), p. 2441 - 2452 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  119 Citations (Scopus)
• 2001

  Bidirectional effects of corticosterone on splenic T-cell activation: critical role of cell density and culture time

  Wiegers, G., Stec, I., Klinkert, W., Linthorst, A. & Reul, J., 2001, In: Neuroendocrinology. 73, p. 139 - 148

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  15 Citations (Scopus)

• Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone

  Gesing, A., Bilang-Bleuel, A., Droste, S., Linthorst, A., Holsboer, F. & Reul, J., 1 Jul 2001, In: Journal of Neuroscience. 21 (13), p. 4822 - 4829 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  193 Citations (Scopus)
• 2000

  Diurnal variations in lipopolysaccharide-induced sleep, sickness behavior and changes in corticosterone levels in the rat

  Mathias, S., Schiffelholz, T., Linthorst, A. C., Pollmächer, T. & Lancel, M., Jun 2000, In: Neuroendocrinology. 71, 6, p. 375-85 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Lipopolysaccharide 100%
  • Corticosterone 100%
  • Sickness Behavior 100%
  • Behavior (Neuroscience) 14%
  • Vigilance 14%
  33 Citations (Scopus)

• Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice

  Linthorst, A. C., Flachskamm, C., Barden, N., Holsboer, F. & Reul, J. M., Jan 2000, In: European Journal of Neuroscience. 12, 1, p. 283-91 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • In Vivo 100%
  • Glucocorticoid Receptor 100%
  • Microdialysis 100%
  • Behavior (Neuroscience) 50%
  • Corticosterone 50%
  96 Citations (Scopus)

• New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders

  Reul, J. M., Bilang-Bleuel, A., Droste, S., Linthorst, A. C., Holsboer, F. & Gesing, A., 2000, In: Zeitschrift für Rheumatologie. 59 Suppl 2, p. II/22-5

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Stress-Related Disorders 100%
  • Mineralocorticoid Receptor 100%
  • Glucocorticoid 100%
  • Hippocampus 50%
  • Receptor Density 50%
  16 Citations (Scopus)

• The brain mineralocorticoid receptor: greedy for ligand, mysterious in function

  Reul, J. M., Gesing, A., Droste, S., Stec, I. S., Weber, A., Bachmann, C., Bilang-Bleuel, A., Holsboer, F. & Linthorst, A. C., 29 Sept 2000, In: European Journal of Pharmacology: Molecular Pharmacology. 405, 1-3, p. 235-49 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mineralocorticoid Receptor 100%
  • Glucocorticoid Receptor 41%
  • In Vivo 25%
  • In Vitro 25%
  • Glucocorticoid 25%
  201 Citations (Scopus)

• Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats

  Hölter, S. M., Linthorst, A. C., Reul, J. M. & Spanagel, R., May 2000, In: Pharmacology, Biochemistry and Behavior. 66, 1, p. 143-51 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Drinking Behavior 100%
  • Withdrawal Syndrome 100%
  • Alcohol Abuse 100%
  • Withdrawal Symptom 100%
  • Wistar Rat 100%
  43 Citations (Scopus)
• 1999

  Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin

  Linthorst, A. C., Karanth, S., Barden, N., Holsboer, F. & Reul, J. M. H. M., Jan 1999, In: European Journal of Neuroscience. 11, 1, p. 178-86 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endotoxin 100%
  • Physiological Response 100%
  • Glucocorticoid Receptor 100%
  • Glucocorticoid 100%
  • Mouse 100%
  19 Citations (Scopus)

• Inflammation and brain function under basal conditions and during long-term elevation of brain corticotropin-releasing hormone levels

  Linthorst, A. C. & Reul, J. M., 1999, In: Advances in Experimental Medicine and Biology. 461, p. 129-52 24 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  27 Citations (Scopus)
• 1998

  Altered neuroimmunoendocrine communication during a condition of chronically increased brain corticotropin-releasing hormone drive

  Reul, J. M., Labeur, M. S., Wiegers, G. J. & Linthorst, A. C., 1 May 1998, In: Annals of the New York Academy of Sciences. 840, p. 444-55 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Immune System 100%
  • Interleukin 1beta 100%
  • Drive 100%
  • Corticotropin-Releasing Hormone 100%
  • Corticotropin Releasing Factor 100%
  28 Citations (Scopus)

• Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior

  Liebsch, G., Linthorst, A. C., Neumann, I. D., Reul, J. M., Holsboer, F. & Landgraf, R., Nov 1998, In: Neuropsychopharmacology. 19, 5, p. 381-96 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Behavior (Neuroscience) 100%
  • Diazepam 100%
  • Adrenocorticotropic Hormone 16%
  • Locomotor Activity 16%
  • Elevated Plus Maze 8%
  143 Citations (Scopus)

• Brain neurotransmission during peripheral inflammation

  Linthorst, A. C. & Reul, J. M., 1 May 1998, In: Annals of the New York Academy of Sciences. 840, p. 139-52 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Inflammation 100%
  • Noradrenalin 100%
  • Norepinephrine 100%
  • Synaptic Transmission 100%
  • Serotonin 66%
  76 Citations (Scopus)

• Tumour necrosis factor-alpha and interleukin-2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic-pituitary-adrenocortical axis activity in the rat

  Pauli, S., Linthorst, A. C. & Reul, J. M., Mar 1998, In: European Journal of Neuroscience. 10, 3, p. 868-78 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Interleukin 2 100%
  • Tumor Necrosis Factor Alpha 100%
  • Serotonergic 100%
  • Synaptic Transmission 100%
  • Tumor Necrosis Factor 100%
  64 Citations (Scopus)
• 1997

  Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function

  Karanth, S., Linthorst, A. C., Stalla, G. K., Barden, N., Holsboer, F. & Reul, J. M., Aug 1997, In: Endocrinology. 138, 8, p. 3476-85 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Transgenic Mouse 100%
  • Glucocorticoid Receptor 100%
  • Adrenocorticotropic Hormone 100%
  • Corticotropin Release 66%
  • Corticosterone 66%
  80 Citations (Scopus)

• Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge

  Linthorst, A. C., Flachskamm, C., Hopkins, S. J., Hoadley, M. E., Labeur, M. S., Holsboer, F. & Reul, J. M., 1 Jun 1997, In: Journal of Neuroscience. 17, 11, p. 4448-60 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cytokine 100%
  • Corticotropin Releasing Factor 100%
  • Corticotropin-Releasing Hormone 100%
  • Lipopolysaccharide 26%
  • Microdialysis 20%
  156 Citations (Scopus)
• 1996

  Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway

  Linthorst, A. C., Flachskamm, C., Holsboer, F. & Reul, J. M., Jun 1996, In: Neuroscience. 72, 4, p. 989-97 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Norepinephrine 100%
  • Serotonin 100%
  • Serotonergic 100%
  • Hippocampus 100%
  • Cyclooxygenase 100%
  84 Citations (Scopus)

• When cytokines get on your nerves: cytokine networks and CNS pathologies

  Toulmond, S., Parnet, P. & Linthorst, A. C., Oct 1996, In: Trends in Neurosciences. 19, 10, p. 409-10 2 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  48 Citations (Scopus)
• 1995

  Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

  Linthorst, A. C., Flachskamm, C., Müller-Preuss, P., Holsboer, F. & Reul, J. M., Apr 1995, In: Journal of Neuroscience. 15, 4, p. 2920-34 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • In Vivo 100%
  • Corticosterone 100%
  • Serotonergic 100%
  • Interleukin 1beta 100%
  • Synaptic Transmission 100%
  221 Citations (Scopus)

• Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotransmission in the rat preoptic area: relationship with body temperature and hypothalamic--pituitary--adrenocortical axis activity

  Linthorst, A. C., Flachskamm, C., Holsboer, F. & Reul, J. M., 1 Dec 1995, In: European Journal of Neuroscience. 7, 12, p. 2418-30 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Norepinephrine 100%
  • Corticosterone 100%
  • Synaptic Transmission 100%
  • Preoptic Area 100%
  • Noradrenalin 100%
  79 Citations (Scopus)

• The nigrostriatal dopamine system and the development of hypertension in the spontaneously hypertensive rat

  de Jong, W., Linthorst, A. C. & Versteeg, H. G., Aug 1995, In: Archives des Maladies du Coeur et des Vaisseaux. 88, 8, p. 1193-6 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Caudate Nucleus 100%
  • Substantia nigra 57%
  • In Vitro 28%
  • Oxidopamine 14%
  • In Vivo 14%
  34 Citations (Scopus)
• 1994

  Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature

  Linthorst, A. C., Flachskamm, C., Holsboer, F. & Reul, J. M., Aug 1994, In: Endocrinology. 135, 2, p. 520-32 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Interleukin-1 100%
  • Hippocampus 100%
  • Body Temperature 100%
  • Synaptic Transmission 100%
  • Interleukin 1beta 100%
  144 Citations (Scopus)