Personal profile
Research interests
My research in the area of paediatric rheumatology includes:
- Randomised controlled trials of novel biological drugs in children with JIA associated uveitis. I am the Co-Chief Investigator of Sycamore Trial (RCT of adalimumab in JIA associated uveitis) funded by HTA/ARUK. I am also the Co-Chief Investigator of a trial of Tocilizumab in anti TNF refractory JIA associated uveitis.
- Leading on new agents for management of refractory arthritis in collaboration with industry
- Design and conduct studies in rare disease using novel study designs (Bayesian and Simon design)
- Looking at diagnostic markers and new therapies for MAS or secondary HLH
- Collaboration with colleagues in India on secondary HLH in Dengue fever
- Basic science studies on understanding pathogenesis of lupus nephritis
- Biomarkers in JIA and JIA associated uveitis.
Activities/Findings:
- Associate Editor – Archives of Diseases in Childhood
- Editorial Board – Rheumatology
- Scientific Member, ARUK/MCRN Paediatric Rheumatology Clinical Studies Group
- Associate Director of ARUK funded only Paediatric Experimental Arthritis Treatment Centre leading on JIA-Uveitis and Industry workstreams
- Medical Advisor for National Rheumatoid Arthritis Society (NRAS) and National Ankylosing Spondylitis Society (NASS)
- Research Advisor for RCPCH Paediatric Rheumatology CSAC.
External positions
Co-Editor
2021 → …
Associate Director, ARUK Paediatric Rheumatology Experimental Arthritis Treatment Centre leading on Industry and Uveitis workstreams
2014 → …
Associate Editor, Archives of Diseases in Childhood
2010 → …
Scientific Member and Champion, MCRN/ARUK Paediatric Rheumatology Clinical Studies Group
2007 → 2023
Bristol Royal Hospital for Children, UK
2004 → …
Keywords
- Randomised controlled trials in paediatric rheumatology, Paediatric Uveitis Immunomodulatory therapy, Trials of novel biological agents including using adaptive designs, Musculoskeletal problems in children, Kawasaki disease
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Collaborations and top research areas from the last five years
Research output
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Validating treat-to-target endpoints in childhood lupus: data-driven sensitivity analyses from the UK JSLE cohort study
Sarker, C., Jorgensen, A. L., Tharmaratnam, K., Al-Abadi, E., Armon, K., Bailey, K., Bohm, M., Brennan, M., Ciurtin, C., Gardner-Medwin, J., Hawley, D. P., Kinder, A., Leahy, A., Malik, G., McLaren, Z., Moraitis, E., Mosley, E., Ramanan, A. V., Rangaraj, S. & Ratcliffe, A. & 6 others, , 1 Feb 2026, In: Rheumatology. 65, 2, 12 p., keag015.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
A Child With Thickened Skin: When the Skin Biopsy Tells a Different Story
Govardhan, C., Prithvi, A., Walker, L., Talakola, P., Udensi, L. & Ramanan, A. V., 20 Nov 2025, (E-pub ahead of print) In: Pediatric Dermatology. 4 p.Research output: Contribution to journal › Comment/debate (Academic Journal)
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Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels
Renaudineau, Y., Charras, A., Natoli, V., Congy-Jolivet, N., Haldenby, S., Liu, X., Fang, Y., Smith, E. M., Beresford, M. W., Hedrich, C. M. & UK jSLE Cohort Study Group, 1 Jun 2025, In: Journal of Translational Autoimmunity. 10, 9 p., 100268.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access4 Citations (Scopus)
Datasets
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Additional file 2 of Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study
Clarke, S. L. N. (Creator), Jones, H. J. (Creator), Sharp, G. C. (Creator), Easey, K. E. (Creator), Hughes, A. D. (Creator), Ramanan, A. V. (Creator) & Relton, C. L. (Creator), figshare, 21 Nov 2022
DOI: 10.6084/m9.figshare.21593823, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Juvenile_idiopathic_arthritis_polygenic_risk_scores_are_associated_with_cardiovascular_phenotypes_in_early_adulthood_a_phenome-wide_association_study/21593823 and one more link, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Juvenile_idiopathic_arthritis_polygenic_risk_scores_are_associated_with_cardiovascular_phenotypes_in_early_adulthood_a_phenome-wide_association_study/21593823/1 (show fewer)
Dataset
Prizes
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Awarded the Best Clinical Science Abstract Award (1 of 6) at the European League Against Rheumatism Annual Conference, London 2016
Ramanan, A. V. (Recipient), 2016
Prize: Prizes, Medals, Awards and Grants
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Best Clinical Science Abstract Award (1 of 6) at the European League Against Rheumatism Annual Conference, London 2016
Ramanan, A. V. (Recipient), 2016
Prize: Prizes, Medals, Awards and Grants
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Bristol Post/Bristol Health Partners Research Impact Award
Ramanan, A. V. (Recipient), 2016
Prize: Prizes, Medals, Awards and Grants