Research output per year
Research output per year
Research output
- 29 results
Search results
-
2023
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
Helliwell, M. V., Zhang, Y., El Harchi, A., Dempsey, C. E. & Hancox, J. C., 24 Aug 2023, In: Pharmaceuticals. 16, 9, 1204.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile5 Citations (Scopus)76 Downloads (Pure) -
2022
Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome:A review.
El Harchi, A. & Brincourt, O., 14 Jun 2022, (E-pub ahead of print) In: Journal of Arrhythmia. 38, 4, p. 554-569 16 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile9 Citations (Scopus)165 Downloads (Pure) -
2020
COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2
et al., 5 May 2020, In: Frontiers in Cardiovascular Medicine. 7, 85, 6 p.Research output: Contribution to journal › Literature review (Academic Journal) › peer-review
Open AccessFile112 Downloads (Pure) -
Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide
Dawidowski, M., Król, M., Szulczyk, B., Chodkowski, A., Podsadni, P., Konopelski, P., Ufnal, M., Szuberski, P., Wróbel, M. Z., Zhang, Y., El Harchi, A., Hancox, J. C., Jarkovska, D., Mistrova, E., Sviglerova, J., Štengl, M., Popowicz, G. M. & Turło, J., 1 May 2020, In: Bioorganic chemistry. 98, 14 p., 103717.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile3 Citations (Scopus)100 Downloads (Pure) -
The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine
El Harchi, A., Butler, A. S., Zhang, Y., Dempsey, C. E. & Hancox, J. C., 8 Mar 2020, In: Physiological Reports. 8, 5, 14 p., e14385.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile4 Citations (Scopus)155 Downloads (Pure) -
2018
Investigation of hERG1b influence on hERG channel pharmacology at physiological temperature
Hancox, J., El Harchi, A., Melgari, D. & Zhang, H., 2018, In: Journal of Pharmacology and Pharmacotherapeutics. 9, 2, p. 92-103 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile8 Citations (Scopus)360 Downloads (Pure) -
Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker
Helliwell, M. V., Zhang, Y., El Harchi, A., Du, C., Hancox, J. C. & Dempsey, C. E., 4 May 2018, In: Journal of Biological Chemistry. 293, 18, p. 7040-7057 38 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile39 Citations (Scopus)333 Downloads (Pure) -
2017
Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria
Whittaker, D. G., Ni, H., Harchi, A. E., Hancox, J. C. & Zhang, H., 13 Jun 2017, In: PLoS Computational Biology. 13, 6, 29 p., e1005593.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile28 Citations (Scopus)338 Downloads (Pure) -
In silico investigation of a KCNQ1 mutation associated with short QT syndrome
Adeniran, I., Whittaker, D. G., El Harchi, A., Hancox, J. C. & Zhang, H., 16 Aug 2017, In: Scientific Reports. 7, 14 p., 8469.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile20 Citations (Scopus)313 Downloads (Pure) -
2016
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
Zhang, Y. H., Colenso, C. K., Harchi, A. E., Cheng, H., Witchel, H. J., Dempsey, C. E. & Hancox, J. C., 1 Aug 2016, In: Biochemical Pharmacology. 113, p. 24-35 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile39 Citations (Scopus)496 Downloads (Pure) -
2015
hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine
Melgari, D., Brack, K. E., Zhang, C., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., 24 Apr 2015, In: Journal of the American Heart Association. 4, 4, p. 1-13Research output: Contribution to journal › Article (Academic Journal) › peer-review
74 Citations (Scopus)26 Downloads (Pure) -
hERG potassium channel inhibition by ivabradine requires channel gating
Melgari, D., Brack, K. E., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., Oct 2015, In: Journal of Molecular and Cellular Cardiology. 87, p. 126-8 3 p.Research output: Contribution to journal › Article (Academic Journal)
2 Citations (Scopus) -
Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sept 2015, In: Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile51 Citations (Scopus)369 Downloads (Pure) -
2014
A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?
Hancox, J. C., Du, C., Harchi, A. E., Baranchuk, A. & Zhang, H., Apr 2014, In: Therapeutic advances in infectious disease. 2, 2, p. 71-2 2 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
2 Citations (Scopus) -
In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation
Hancox, J. C., Kharche, S., El Harchi, A., Stott, J., Law, P. & Zhang, H., 15 Jan 2014, In: Journal of Electrocardiology. 47, 2, p. 158-165 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
12 Citations (Scopus) -
Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism
Hancox, J. C., Du, C., El Harchi, A. & Zhang, H., 2014, In: Circulation Research. 78, 9, p. 2330Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants
Du, C., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sept 2014, In: Journal of Molecular and Cellular Cardiology. 74, p. 220-230 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile44 Citations (Scopus)594 Downloads (Pure) -
Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration
Melgari, D., Du, C., El Harchi, A., Zhang, Y. & Hancox, J. C., 1 Oct 2014, In: Physiological Reports. 2, 10Research output: Contribution to journal › Article (Academic Journal) › peer-review
7 Citations (Scopus)31 Downloads (Pure) -
2013
Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition
Du, C., El Harchi, A., Zhang, H. & Hancox, J. C., Nov 2013, In: Physiological Reports. 1, 6, p. e00175Research output: Contribution to journal › Article (Academic Journal) › peer-review
21 Citations (Scopus) -
2012
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel
El Harchi, A., Melgari, D., Zhang, Y. H., Zhang, H. & Hancox, J. C., 2012, In: PLoS ONE. 7, 12, p. e52451Research output: Contribution to journal › Article (Academic Journal) › peer-review
21 Citations (Scopus) -
Molecular determinants of hERG potassium channel inhibition by disopyramide
El Harchi, A., Zhang, Y., Hussein, L., Dempsey, C. & Hancox, J., Jan 2012, In: Journal of Molecular and Cellular Cardiology. 52, 1, p. 185 - 195 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
30 Citations (Scopus) -
Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling
Adeniran, I., El Harchi, A., Hancox, J. C. & Zhang, H., 1 Apr 2012, In: Cardiovascular Research. 94, 1, p. 66-76Research output: Contribution to journal › Article (Academic Journal) › peer-review
50 Citations (Scopus) -
2011
Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform
Du, C., El Harchi, A., McPate, M., Orchard, C. & Hancox, J., 2011, In: Biochemical and Biophysical Research Communications. 405, p. 222 - 227Research output: Contribution to journal › Article (Academic Journal) › peer-review
16 Citations (Scopus) -
Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis
Du, C., El Harchi, A., Zhang, Y., Orchard, C. & Hancox, J., 2011, In: Journal of Cardiovascular Electrophysiology. p. in pressResearch output: Contribution to journal › Article (Academic Journal) › peer-review
35 Citations (Scopus) -
The short QT syndrome
Hancox, J., McPate, M., El Harchi, A., Duncan, R., Dempsey, C., Witchel, H., Adeniran, I. & Zhang, H., 2011, Heart Rate and Rhythm., T. (ed.). Springer-Verlag Berlin, p. 431 - 449 19 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
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2010
Acidosis Impairs the Protective Role of hERG K(+) Channels Against Premature Stimulation
Du, C., Adeniran, I., Cheng, H., Zhang, Y., El Harchi, A., McPate, M., Zhang, H., Orchard, C. & Hancox, J., 2010, In: Journal of Cardiovascular Electrophysiology. 21, p. 1160 - 1169Research output: Contribution to journal › Article (Academic Journal) › peer-review
26 Citations (Scopus) -
Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation
El Harchi, A., McPate, M., Zhang, Y. & Hancox, J., 2010, In: Journal of Physiology and Pharmacology. 61, p. 123 - 131Research output: Contribution to journal › Article (Academic Journal) › peer-review
22 Citations (Scopus) -
2009
Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
El Harchi, A., McPate, M., Zhang, Y., Zhang, H. & Hancox, J., 2009, In: Journal of Molecular and Cellular Cardiology. 47, p. 743 - 747Research output: Contribution to journal › Article (Academic Journal) › peer-review
36 Citations (Scopus) -
2008
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
Hancox, J., McPate, M., El Harchi, A. & Zhang, Y., Aug 2008, In: Pharmacology and Therapeutics. 119, 2, p. 118 - 132 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
249 Citations (Scopus)