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Our lab is interested in the processes of tissue repair and regeneration and in modelling different aspects of human cardiovascular disease. We are particularly interested in the inflammatory response to tissue injury and the roles this may play in promoting regeneration of damaged organs. The inflammatory response to an acute or ischaemic injury (such as a myocardial infarction) is an inevitable and necessary part of the repair process but directly drives subsequent fibrosis and scar formation in mammals. We use zebrafish to study how tissue regeneration occurs in this vertebrate model system with a particular interest in their ability to remove deposited scar tissue.
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- 3 Finished
Copy of The Role of inflamatory cell signalling during cardiac scar formation and regression in adult zebrafish
1/07/15 → 30/06/19
1/06/15 → 31/08/17
In Vivo Characterization of Endogenous Cardiovascular Extracellular Vesicles in Larval and Adult Zebrafish: Endogenous cardiovascular extracellular vesiclesScott, A., Sueiro Ballesteros, L., Bradshaw, M., Tsuji, C., Power, A., Lorriman, J., Love, J., Paul, D. M., Herman, A., Emanueli, C. & Richardson, R., Sep 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 9, p. 2454-2468 15 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access1 Citation (Scopus)
Moyse, B. R. & Richardson, R., 1 Aug 2020, In: ImmunoHorizons. 4, 8, p. 464-474 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile38 Downloads (Pure)
Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafishBevan, L., Lim, Z. W., Venkatesh, B., Riley, P. R., Martin, P. & Richardson, R., 1 Jun 2020, In: Cardiovascular Research. 116, 7, p. 1357-1371 15 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile165 Downloads (Pure)