Projects per year
Personal profile
Research interests
We are interested in the mechanisms controlling the spatial regulation of nutrient homeostasis in health, senescence and cancer.
In healthy cells, a dynamic balance between biosynthesis, degradation and recycling supports growth. This is controlled, at least in part by the pro-growth mammalian target of rapamycin complex 1 (mTORC1) and the degradative autophagy-lysosome pathway. mTORC1 is activated by nutrients and energy to control protein translation, lipid and nucleotide synthesis while autophagy involves the sequestration of cytoplasmic contents in both selective and non-selective (bulk) ways to deliver them to the lysosome for degradation. Importantly, there is extremely tight reciprocal control between mTORC1 and the autophagy-lysosome pathway to maintain proteostasis and homeostasis. We are studying the mechanisms controlling the localisation and activity of these processes and how rewiring of this equilibrium contributes to cellular senescence (a tumour suppressor mechanism of cell cycle arrest) and cancer.
Keywords
- mTORC1, autophagy, lysosomes, senescence, melanoma
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Collaborations and top research areas from the last five years
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Defining a role for non-canonical mTORC1 activation in wound healing
3/01/24 → 2/01/27
Project: Research
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Research output
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TFEB-dependent lysosome biogenesis is required for senescence
Curnock, R. M., Yalci, K. Y., Palmfeldt, J., Jaattela, M., Liu, B. & Carroll, B. M., 27 Mar 2023, In: The EMBO journal. 42, 9, e111241.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)45 Downloads (Pure) -
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy
Kataura, T., Otten, E. G., Rabanal-Ruiz, Y., Adriaenssens, E., Urselli, F., Scialo, F., Fan, L., Smith, G. R., Dawson, W. M., Chen, X., Yue, W. W., Bronowska, A. K., Carroll, B., Martens, S., Lazarou, M. & Korolchuk, V. I., 14 Dec 2022, (E-pub ahead of print) In: EMBO Journal. p. e111372Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access11 Citations (Scopus) -
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
Genomics England Research Consortium, 4 Feb 2021, In: Cell. 184, 3, p. 655-674.e27 48 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile42 Citations (Scopus)126 Downloads (Pure)