Photo of Boris Simonetti

Mr Boris Simonetti

BSc(Trieste), MSc(Paris VII)

  • BS8 1TD

20172020

Research output per year

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Personal profile

Research interests

Mechanisms for endosomal sorting of membrane proteins.

Cells within tissues and organs must efficiently communicate with one another and sense the extracellular environment. This is achieved by the presence of membrane proteins, such as receptors, ion channels and nutrient transporters. To ensure that the membrane proteins are expressed at the correct location, cells have evolved highly organised intracellular sorting pathways, such as the endosomal pathway.
Professor Cullen's group studies the mechanisms of protein sorting by multiprotein complexes that function through the endosomal pathway. My research focus is to understand the molecular basis for protein recycling by endosome-associated SNX-BARs, and its implications in host-pathogen interactions. To achieve these aims, I use biochemical and cellular techniques, including knock-down or knock-out approaches, imaging techniques, together with extensive proteomics.

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Research Output

  • 4 Article (Academic Journal)
  • 2 Review article (Academic Journal)

Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting

Evans, A. J., Daly, J., Anuar, A. N. K., Simonetti, B. & Cullen, P. J., 3 Aug 2020, In : Journal of Cell Science. 133, jcs246033.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 25 Downloads (Pure)

    A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

    Anton, Z., Betin, V. M. S., Simonetti, B., Traer, C. J., Attar, N., Cullen, P. J. & Lane, J. D., 15 Jul 2020, In : Journal of Cell Science. 133, 14, 38 p., jcs246306.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 41 Downloads (Pure)

    Actin-dependent endosomal receptor recycling

    Simonetti, B. & Cullen, P. J., Feb 2019, In : Current Opinion in Cell Biology. 56, p. 22-33 12 p.

    Research output: Contribution to journalReview article (Academic Journal)

    Open Access
    File
  • 13 Citations (Scopus)
    250 Downloads (Pure)