Projects per year
The overall aim of work in this laboratory is to understand central nervous system mechanisms of nociception and pain. The focus is on the physiology, anatomy and neurochemistry of descending control systems that originate in the brainstem and that act to co-ordinate changes in motor, autonomic and sensory functions, including pain. These systems underlie the co-ordinated patterns of change in behaviour, nociceptive responsiveness and autonomic outflow that occur: (i) during fever, as part of a sickness response (ii) in different behavioural states, such as fear and anxiety, (iii) in certain pathophysiological conditions, such as stress related disorders and chronic pain.
A better understanding of the neural basis of pain will help develop new strategies for the treatment of chronic pain, such as that which accompanies arthritis.
25/05/21 → 24/05/24
Dynamic contributions of prefrontal-midbrain-spinal cord networks to the development and maintenance of chronic neuropathic pain.
1/01/17 → 31/12/19
Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in ratsDrake, R. A. R., Lumb, B. M., Apps, R. & Pickering, A. E., 8 Feb 2021, In: eLife. 10, p. 1-22 22 p., e65156.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Downloads (Pure)
The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivationPhelps, C. E., Lumb, B. M., Donaldson, L. F. & Robinson, E. S. J., 1 Mar 2021, In: PAIN. 162, 3, p. 956-966 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Apps, R., Hawkes, R., Aoki, S., Bengtsson, F., Brown, A. M., Chen, G., Ebner, T. J., Isope, P., Jörntell, H., Lackey, E. P., Lawrenson, C., Lumb, B., Schonewille, M., Sillitoe, R. V., Spaeth, L., Sugihara, I., Valera, A., Voogd, J., Wylie, D. R. & Ruigrok, T. J. H., 6 Jun 2018, (E-pub ahead of print) In: Cerebellum. 29 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile41 Citations (Scopus)385 Downloads (Pure)
1 Jul 2018 → 2 Jul 2018
Activity: Participating in or organising an event types › Participation in workshop, seminar, course