Projects per year
Personal profile
Research interests
The overall aim of work in this laboratory is to understand central nervous system mechanisms of nociception and pain. The focus is on the physiology, anatomy and neurochemistry of descending control systems that originate in the brainstem and that act to co-ordinate changes in motor, autonomic and sensory functions, including pain. These systems underlie the co-ordinated patterns of change in behaviour, nociceptive responsiveness and autonomic outflow that occur: (i) during fever, as part of a sickness response (ii) in different behavioural states, such as fear and anxiety, (iii) in certain pathophysiological conditions, such as stress related disorders and chronic pain.
A better understanding of the neural basis of pain will help develop new strategies for the treatment of chronic pain, such as that which accompanies arthritis.
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Projects
Susceptibility to Chronic Pain: role of cerebellar - Periaqueductal Gray Communication
1/08/20 → 31/07/23
Project: Research
Dynamic contributions of prefrontal-midbrain-spinal cord networks to the development and maintenance of chronic neuropathic pain.
1/01/17 → 31/12/19
Project: Research
LOCAL TRANSLATION OF MRNA IN PRIMARY AFFERENT FIBRES: A NOVEL MECHANISM FOR THE CONTROL OF PAIN AND ITCH
26/05/09 → 26/08/12
Project: Research
Research Output
Cerebellar Modules and Their Role as Operational Cerebellar Processing Units
Apps, R., Hawkes, R., Aoki, S., Bengtsson, F., Brown, A. M., Chen, G., Ebner, T. J., Isope, P., Jörntell, H., Lackey, E. P., Lawrenson, C., Lumb, B., Schonewille, M., Sillitoe, R. V., Spaeth, L., Sugihara, I., Valera, A., Voogd, J., Wylie, D. R. & Ruigrok, T. J. H., 6 Jun 2018, In : Cerebellum. 29 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Correction to: Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper
Apps, R., Hawkes, R., Aoki, S., Bengtsson, F., Brown, A. M., Chen, G., Ebner, T. J., Isope, P., Jörntell, H., Lackey, E. P., Lawrenson, C., Lumb, B., Schonewille, M., Sillitoe, R. V., Spaeth, L., Sugihara, I., Valera, A., Voogd, J., Wylie, D. R. & Ruigrok, T. J. H., 21 Jun 2018, (Accepted/In press) In : Cerebellum. p. 1-2 2 p.Research output: Contribution to journal › Comment/debate (Academic Journal)
The mystery of the cerebellum: clues from experimental and clinical observations
Lawrenson, C., Bares, M., Kamondi, A., Kovács, A., Lumb, B., Apps, R., Filip, P. & Manto, M., Dec 2018, In : Cerebellum and Ataxias. 5, 11 p., 8.Research output: Contribution to journal › Review article (Academic Journal)
Open Access
File
Activities
- 1 Participation in workshop, seminar, course
Early career investigators’ grant funding workshop: The role of the cerebellum in fear circuits.
Charlotte L Lawrenson (Organiser), , R Apps (Participant), , Bridget Lumb (Participant), & Elena Paci (Participant)
1 Jul 2018 → 2 Jul 2018
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Supervised Work
The role of the anterior hypothalamus in the co-ordination of autonomic and sensory functions including pain
Author: Simpson, D. A. A., 2003Supervisor: Lumb, B. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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