Projects per year
Personal profile
Research interests
The overall aim of work in this laboratory is to understand central nervous system mechanisms of nociception and pain. The focus is on the physiology, anatomy and neurochemistry of descending control systems that originate in the brainstem and that act to co-ordinate changes in motor, autonomic and sensory functions, including pain. These systems underlie the co-ordinated patterns of change in behaviour, nociceptive responsiveness and autonomic outflow that occur: (i) during fever, as part of a sickness response (ii) in different behavioural states, such as fear and anxiety, (iii) in certain pathophysiological conditions, such as stress related disorders and chronic pain.
A better understanding of the neural basis of pain will help develop new strategies for the treatment of chronic pain, such as that which accompanies arthritis.
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- 1 Similar Profiles
Network
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Susceptibility to Chronic Pain: role of cerebellar - Periaqueductal Gray Communication
25/05/21 → 24/05/24
Project: Research
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Dynamic contributions of prefrontal-midbrain-spinal cord networks to the development and maintenance of chronic neuropathic pain.
1/01/17 → 31/12/19
Project: Research
Research output
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Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour
Lawrenson, C. L., Paci, E., Pickford, J., Drake, R. A. R., Lumb, B. M. & Apps, R., 15 Mar 2022, In: eLife. 11, 30 p., e76278.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile6 Downloads (Pure) -
Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats
Drake, R. A. R., Lumb, B. M., Apps, R. & Pickering, A. E., 8 Feb 2021, In: eLife. 10, p. 1-22 22 p., e65156.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile4 Citations (Scopus)79 Downloads (Pure) -
The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation
Phelps, C. E., Lumb, B. M., Donaldson, L. F. & Robinson, E. S. J., 1 Mar 2021, In: PAIN. 162, 3, p. 956-966 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile16 Downloads (Pure)
Activities
- 1 Participation in workshop, seminar, course
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Early career investigators’ grant funding workshop: The role of the cerebellum in fear circuits.
Charlotte L Lawrenson (Organiser), R Apps (Participant), Bridget Lumb (Participant) & Elena Paci (Participant)
1 Jul 2018 → 2 Jul 2018Activity: Participating in or organising an event types › Participation in workshop, seminar, course