Dr Bronwen R Burton

BSc(Bristol), PhD

  • BS8 1TD

20082018

Research output per year

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Personal profile

Research interests

Developing antigen-specific immunotherapy for the treatment of autoimmune disease

Antigen-specific immunotherapy specifically targets the cells of the immune system causing autoimmune disease, preventing these cells from attacking the body's own tissues without compromising normal immune function. In the case of multiple sclerosis, CD4+ T cells mistakenly respond to peptide antigens which are components of the myelin sheath. Antigen-specific immunotherapy involves exposing the immune system to these target peptides in a carefully controlled way, which re-educates pathogenic CD4+ T cells; a process known as therapeutic tolerance induction. Autoimmunity is prevented by causing a switch in self-reactive cells to an anti-inflammatory, IL-10-secreting regulatory cell type. I am interested in strategies to improve development of this approach for the treatment of autoimmunity, including:

  • Understanding the molecular mechanisms underlying successful tolerance induction
  • Optimising dosing strategies to improve immunotherapy
  • Adjunct therapies to boost antigen-specific tolerance induction
  • Identification of biomarkers of tolerance induction
  • Differential regulation of effector T cell subsets by regulatory T cell populations

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Research Output

  • 11 Article (Academic Journal)
  • 1 Conference Poster

Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice

Kemp, K., Hares, K., Redondo, J., Cook, A., Haynes, H., Burton, B., Pook, M., Rice, C., Scolding, N. & Wilkins, A., 23 Apr 2018, In : Annals of Neurology. 83, 4, p. 779-793 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 8 Citations (Scopus)
    310 Downloads (Pure)

    Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

    Burton, B., 1 May 2018, In : eLife. 7, 14 p., e26832.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 5 Citations (Scopus)
    361 Downloads (Pure)

    Cytokine therapy-mediated neuroprotection in a Friedreich's ataxia mouse model

    Kemp, K., Cerminara, N., Hares, K., Redondo, J., Cook, A., Haynes, H., Burton, B., Pook, M., Apps, R., Scolding, N. & Wilkins, A., Feb 2017, In : Annals of Neurology. 81, 2, p. 212-226 15 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 9 Citations (Scopus)
    346 Downloads (Pure)