20022020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Adverse childhood experiences, DNA methylation age acceleration and cortisol in UK children: a prospective population-based cohort study

Tang, R., Howe, L. D., Suderman, M. J., Relton, C. L., Crawford, A. A. & Houtepen, L. C., 7 Apr 2020, In : Clinical Epigenetics. 12, 9 p., 55 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
27 Downloads (Pure)

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

Marini, S., Davis, K. A., Soare, T. W., Zhu, Y., Suderman, M. J., Simpkin, A. J., Smith, A. D. A. C., Wolf, E. J., Relton, C. L. & Dunn, E. C., 1 Mar 2020, In : Psychoneuroendocrinology. 113, 104484.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Associations Between High Blood Pressure and DNA Methylation

Kazmi, N., Elliott, H. R., Burrows, K., Tillin, T., Hughes, A. D., Chaturvedi, N., Gaunt, T. R. & Relton, C. L., 30 Jan 2020, In : PLoS ONE. 15, 1, 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
53 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
61 Downloads (Pure)
Open Access
File
22 Downloads (Pure)

Causal relationships between lipid and glycemic levels in an Indian population: A bidirectional Mendelian randomization approach

Agarwal, T., Lyngdoh, T., Dudbridge, F., Chandak, G. R., Kinra, S., Prabhakaran, D., Reddy, K. S., Relton, C. L., Davey Smith, G., Ebrahim, S., Gupta, V. & Walia, G. K., 29 Jan 2020, In : PLoS ONE. 15, 1, p. e0228269

Research output: Contribution to journalArticle (Academic Journal)

Changes of DNA methylation are associated with changes in lung function during adolescence

Sunny, S. K., Zhang, H., Rezwan, F. I., Relton, C. L., Henderson, A. J., Merid, S. K., Melén, E., Hallberg, J., Arshad, S. H., Ewart, S. & Holloway, J. W., 7 Apr 2020, In : Respiratory Research. 21, 1, p. 80

Research output: Contribution to journalArticle (Academic Journal)

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

Dardani, C., Howe, L. J. M. S., Mukhopadhyay, N., Stergiakouli, E., Wren, Y. E., Humphries, K. J., Davies, A. J. V., Ho, K. M., Weinberg, S., Marazita, M., Mangold, E., Ludwig, K., Relton, C. L., Davey Smith, G., Lewis, S. J., Sandy, J. R., Davies, N. M. & Sharp, G. C., 25 Feb 2020, (Accepted/In press) In : International Journal of Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer

Langdon, R. J., Beynon, R. A., Ingarfield, K., Marioni, R. E., MacCartney, D. M., Martin, R. M., Ness, A. R., Pawlita, M., Waterboer, T., Relton, C., Thomas, S. J. & Richmond, R. C., 22 Apr 2020, In : Clinical Epigenetics. 12, 14 p., 58 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
19 Downloads (Pure)

Epigenome-wide association study of seizures in childhood and adolescence

Caramaschi, D., Hatcher, C., Mulder, R. H., Felix, J. F., Cecil, C. A. M., Relton, C. L. & Walton, E., 8 Jan 2020, In : Clinical Epigenetics. 12, 13 p., 8 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
78 Downloads (Pure)

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Merid, S. K., Sharp, G. C., Küpers, L. K., Kazmi, N., Lawlor, D. A., Relton, C. L., Sørensen, T. I. A. & al., E., 2 Mar 2020, In : Genome Medicine. 12, 17 p., 25 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
26 Downloads (Pure)

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Mulder, R. H., Walton, E., Neumann, A., Houtepen, L. C., Felix, J. F., Bakermans-Kranenburg, M. J., Suderman, M., Tiemeier, H., van IJzendoorn, M. H., Relton, C. L. & Cecil, C. A. M., 28 Jan 2020, In : Epigenetics. 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
49 Downloads (Pure)

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

Langdon, R. J., Richmond, R. C., Elliott, H. R., Dudding, T., Kazmi, N., Penfold, C., Ingarfield, K., Ho, K. M., Bretherick, A. D., Haley, C. S., Zeng, Y., Walker, R., Pawlita, M., Waterboer, T., Gaunt, T. R., Davey Smith, G., Suderman, M. J., Thomas, S. J., Ness, A. R. & Relton, C. L., 29 Jun 2020, In : Clinical Epigenetics. 12, 19 p., 95 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

Kachuri, L., Johansson, M., Rashkin, S., Graff, R., Bossé, Y., Manem, V., Caporaso, N. E., Landi, M. T., Christiani, D. C., Vineis, P., Liu, G., Scelo, G., Zaridze, D., Shete, S., Albanes, D., Aldrich, M., Tardon, A., Rennert, G., Chen, C., Goodman, G. E. & 31 others, Doherty, J. A., Bickeböller, H., Field, J. K., Davis, M., Teare, M. D., Kiemeney, L. A. L. M., Bojesen, S. E., Haugen, A., Zienolddiny, S., Lam, S., Le Marchand, L., Cheng, I., Schabath, M. B., Duell, E. J., Andrew, A. S., Manjer, J., Lazarus, P., Arnold, S. M., McKay, J. D., Emami, N., Warkentin, M., Brhane, Y., Obeidat, M., Martin, R. M., Relton, C. L., Davey Smith, G., Haycock, P. C., Amos, C. I., Brennan, P., Witte, J. S. & Hung, R. J., 7 Jan 2020, In : Nature Communications. 11, 1, 14 p., 27 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
90 Downloads (Pure)
Open Access
File
38 Downloads (Pure)

Testing for causality between systematically identified risk factors and glioma: A Mendelian randomization study

Howell, A. E., Robinson, J. W., Wootton, R. E., McAleenan, A., Tsavachidis, S., Ostrom, Q. T., Bondy, M., Armstrong, G., Relton, C., Haycock, P., Martin, R. M., Zheng, J. & Kurian, K. M., 3 Jun 2020, In : BMC Cancer. (2020) 20, 508, 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Downloads (Pure)

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

Reed, Z. E., Suderman, M. J., Relton, C. L., Davis, O. S. P. & Hemani, G., 30 Mar 2020, In : Clinical Epigenetics. 12, 50 (2020), 13 p., 50 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Downloads (Pure)
2019
Open Access
File
1 Citation (Scopus)
185 Downloads (Pure)
2 Citations (Scopus)

Appraising the causal relevance of DNA methylation for risk of lung cancer

Battram, T., Richmond, R., Baglietto, L., Haycock, P., Perduca, V., Bojensen, S., Gaunt, T., Hemani, G., Guida, F., Carreras-Torres, R., Hung, R. J., Amos, C. I., Freeman, J., Sandanger, T. M., Nøst, T., Nordestgaard, B. G., Teschendorff, A. E., Polidoro, S., Vineis, P., Severi, G. & 7 others, Hodge, A., Giles, G. G., Grankvist, K., Johansson, M., Johansson, M., Davey Smith, G. & Relton, C., 24 Sep 2019, In : International Journal of Epidemiology. 12 p., dyz190.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
119 Downloads (Pure)

Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis

Yarmolinsky, J., Relton, C. L., Lophatananon, A., Muir, K., Menon, U., Gentry-Maharaj, A., Walther, A., Zheng, J., Fasching, P., Zheng, W., Yin Ling, W., Park, S. K., Kim, B-G., Choi, J-Y., Park, B., Davey Smith, G., Martin, R. M. & Lewis, S. J., 7 Aug 2019, In : PLoS Medicine. 16, 8, 22 p., e1002893.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
126 Downloads (Pure)

A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57

Irwin, R., Thursby, S-J., Ondičová, M., Pentieva, K., McNulty, H., Richmond, R., Caffrey, A., Lees-Murdock, D., McLaughlin, M., Cassidy, T., Suderman, M., Relton, C. & Walsh, C., 1 Dec 2019, In : Clinical Epigenetics. 11, 1, 16 p., 31.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
213 Downloads (Pure)

Changes in DNA methylation from pre-to post-adolescence are associated with pubertal exposures

Han, L., Zhang, H., Kaushal, A., Rezwan, F. I., Kadalayil, L., Karmaus, W., Henderson, A. J., Relton, C. L., Ring, S., Arshad, S. H., Ewart, S. L. & Holloway, J. W., 2 Dec 2019, In : Clinical Epigenetics. 11, 1, 176.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
60 Downloads (Pure)

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

Huang, J. Y., Larose, T. L., Luu, H. N., Wang, R., Fanidi, A., Alcala, K., Stevens, V. L., Weinstein, S. J., Albanes, D., Caporaso, N. E., Purdue, M. P., Ziegler, R. G., Freedman, N. D., Lan, Q., Prentice, R. L., Pettinger, M., Thomson, C. A., Cai, Q., Wu, J., Blot, W. J. & 34 others, Shu, X-O., Zheng, W., Arslan, A. A., Zeleniuch-Jacquotte, A., Le Marchand, L., Wilkens, L. R., Haiman, C. A., Zhang, X., Stampfer, M. J., Han, J., Giles, G. G., Hodge, A. M., Severi, G., Johansson, M., Grankvist, K., Langhammer, A., Hveem, K., Xiang, Y-B., Li, H-L., Gao, Y-T., Visvanathan, K., Ueland, P. M., Midttun, Ø., Ulvi, A., Buring, J. E., Lee, I-M., Sesso, H. D., Gaziano, J. M., Manjer, J., Relton, C., Koh, W-P., Brennan, P., Johansson, M. & Yuan, J-M., 22 Jul 2019, In : International Journal of Cancer. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Adams, C., Richmond, R. C., Santos Ferreira, D. L. D., Spiller, W., Tan, V. Y., Zheng, J., Wurtz, P., Donovan, J. L., Hamdy, F. C., Neal, D. E., Lane, J. A., Davey Smith, G., Relton, C. L., Eeles, R. A., Henderson, B. E., Haiman, C. A., Kote-Jarai, Z., Schumacher, F. R., Amin Al Olama, A., Benlloch, S. & 57 others, Muir, K., Berndt, S. I., Conti, D. V., Wiklund, F., Chanock, S. J., Gapstur, S. M., Stevens, V. L., Tangen, C. M., Batra, J., Clements, J. A., Grönberg, H., Pashayan, N., Schleutker, J., Albanes, D., Wolk, A., West, C. M. L., Mucci, L. A., Cancel-Tassin, G., Koutros, S., Sørensen, K. D., Maehle, L., Travis, R. C., Hamilton, R., Ingles, S. A., Rosenstein, B. S., Lu, Y-J., Giles, G. G., Kibel, A. S., Vega, A., Kogevinas, M., Penney, K. L., Park, J. Y., Stanford, J. L., Cybulski, C., Nordestgaard, B. G., Brenner, H., Maier, C., Kim, J., John, E. M., Teixeira, M. R., Neuhausen, S. L., DeRuyck, K., Razack, A., Newcomb, L. F., Lessel, D., Kaneva, R. P., Usmani, N., Claessens, F., Townsend, P., Gago Dominguez, M., Roobol, M. J., Menegaux, F., Khaw, K-T., Cannon-Albright, L. A., Pandha, H., Thibodeau, S. N. & Martin, R. M., Jan 2019, In : Cancer Epidemiology, Biomarkers and Prevention. 28, 1, p. 208-216 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
230 Downloads (Pure)

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C-J., Vives-Usano, M., Rezwan, F. I., Felix, J. F., Ward, J. M., Guan, W., Richmond, R. C., Brody, J. A., Kupers, L. K., Baïz, N., Haberg, S. E., Smith, J. A., Reese, S. E., Aslibekyan, S., Hoyo, C., Dhingra, R., Markunas, C. A. & 2 others, Relton, C. L. & al., E., 19 Sep 2019, In : Epigenomics. 11, 13, p. 1487-1500 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
113 Downloads (Pure)

Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortium

Aubert, A. M., Forhan, A., de Lauzon-Guillain, B., Chen, L-W., Polanska, K., Hanke, W., Jankowska, A., Mensink-Bout, S. M., Duijts, L., Suderman, M., Relton, C. L., Crozier, S. R., Harvey, N. C., Cooper, C., McAuliffe, F. M., Kelleher, C. C., Phillips, C. M., Heude, B. & Bernard, J. Y., 8 Nov 2019, In : Nutrients. 11, 11

Research output: Contribution to journalArticle (Academic Journal)

Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation

Shah, U. J., Xie, W., Flyvbjerg, A., Nolan, J. J., Højlund, K., Walker, M., Relton, C. L., Elliott, H. R. & for the RISC consortium, Feb 2019, In : Diabetes Research and Clinical Practice. 148, p. 189-199 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
179 Downloads (Pure)

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., Ideker, T., Issa, J-P. J., Kelsey, K. T., Marioni, R. E., Reik, W., Relton, C. L., Schalkwyk, L. C., Teschendorff, A. E., Wagner, W., Zhang, K. & 1 others, Rakyan, V. K., 25 Nov 2019, In : Genome Biology. 20, 1, p. 249

Research output: Contribution to journalReview article (Academic Journal)

14 Citations (Scopus)

DNA methylation and type 2 diabetes: the use of Mendelian randomization to assess causality

Juvinao-Quintero, D. L., Hivert, M-F., Sharp, G. C., Relton, C. L. & Elliott, H. R., 1 Dec 2019, In : Current Genetic Medicine Reports. 7, p. 191–207 17 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
72 Downloads (Pure)

DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

Wiklund, P., Karhunen, V., Richmond, R. C., Parmar, P., Rodriguez, A., De Silva, M., Wielscher, M., Rezwan, F. I., Richardson, T. G., Veijola, J., Herzig, K. H., Holloway, J. W., Relton, C. L., Sebert, S. & Järvelin, M. R., 1 Jul 2019, In : Clinical Epigenetics. 11, 1, 16 p., 97.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
123 Downloads (Pure)

DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood

Odintsova, V., Hagenbeek, F. A., Suderman, M., Caramaschi, D., Beijsterveldt, C. E. M. V., Kallsen, N. A., Ehli, E. A., Davies, G. E., Sukhikh, G. T., Fanos, V., Relton, C., Bartels, M., Boomsma, D. I. & van Dongen, J., 17 Nov 2019, In : Nutrients. 11, 11, 26 p., 2804.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
77 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
88 Downloads (Pure)

Epigenome-wide association study of asthma- and wheeze characterizes loci within HK1

Everson, T. M., Zhang, H., Lockett, G. A., Kaushal, A., Forthofer, M., Ewart, S., Burrows, K., Relton, C., Sharp, G., Henderson, J., Patil, V., Rezwan, F. I., Arshad, H., Holloway, J. W. & Karmaus, W., 24 Jul 2019, In : Allergy, Asthma and Clinical Immunology. 15, 12 p., 43 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
63 Downloads (Pure)

Epigenome-wide meta-analysis of DNA methylation and childhood asthma

BIOS Consortium, 1 Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2062-2074 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
25 Citations (Scopus)
244 Downloads (Pure)

Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate

Howe, L., Richardson, T., Arathimos, R., Alvizi, L., Passos-Bueno, M. R., Stanier, P., Nohr, E. A., Ludwig, K., Mangold, E., Knapp, M., Stergiakouli, E., St Pourcain, B., Davey Smith, G., Sandy, J., Relton, C., Lewis, S., Hemani, G. & Sharp, G., 1 Feb 2019, In : Epigenomics. 11, 2, p. 133-145 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
163 Downloads (Pure)

Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia

Timms, J. A., Relton, C. L., Sharp, G. C., Rankin, J., Strathdee, G. & McKay, J. A., 1 Dec 2019, In : International Journal of Cancer. 145, 11, p. 2933-2943 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
64 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
151 Downloads (Pure)

Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study

Gupta, V., Saxena, R., Walia, G. K., Aggarwal, T., Dunn, W. B., Relton, C. L., Sovio, U., Papageorghiou, A., Davey Smith, G., Khadgawal, R. & Sachdeva, M. P., 1 May 2019, In : BMJ Open. 9, 4, 12 p., e025395.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
142 Downloads (Pure)

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns: Findings From the Pregnancy and Childhood Epigenetics Consortium

Kazmi, N., Sharp, G. C., Reese, S. E., Vehmeijer, F. O., Lahti, J., Page, C. M., Zhang, W., Rifas-Shiman, S. L., Rezwan, F. I., Simpkin, A. J., Burrows, K., Richardson, T. G., Santos Ferreira, D. L., Fraser, A., Harmon, Q. E., Zhao, S., Jaddoe, V. W. V., Czamara, D., Binder, E. B., Magnus, M. C. & 23 others, Håberg, S. E., Nystad, W., Nohr, E. A., Starling, A. P., Kechris, K. J., Yang, I. V., DeMeo, D. L., Litonjua, A. A., Baccarelli, A., Oken, E., Holloway, J. W., Karmaus, W., Arshad, S. H., Dabelea, D., Sørensen, T. I. A., Laivuori, H., Raikkonen, K., Felix, J. F., London, S. J., Hivert, M. F., Gaunt, T. R., Lawlor, D. A. & Relton, C. L., 1 Aug 2019, In : Hypertension. 74, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
138 Downloads (Pure)

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

Richmond, R., Anderson, E., Dashti, H. S., Jones, S. E., Lane, J. M., Strand, L. B., Brumpton, B., Rutter, M. K., Wood, A. R., Straif, K., Relton, C., Munafo, M., Frayling, T. M., Martin, R., Saxena, R., Weedon, M. N., Lawlor, D. & Davey Smith, G., 26 Jun 2019, In : BMJ. 365, p. 480 1 p., l2327.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
99 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
192 Downloads (Pure)

Is high vitamin B12 status a cause of lung cancer?

on behalf of the LC3 consortium and the TRICL consortium, 15 Sep 2019, In : International Journal of Cancer. 145, 6, p. 1499-1503 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
41 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
164 Downloads (Pure)

Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences

Roberts, S., Suderman, M., Zammit, S., Watkins, S. H., Hannon, E., Mill, J., Relton, C., Arseneault, L., Wong, C. C. Y. & Fisher, H. L., 4 Feb 2019, In : Translational Psychiatry. 9, 1, 12 p., 69.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
229 Downloads (Pure)