Projects per year
Our work is of relevance to tumour cell motility and invasion. We are interested in understanding the molecular pathways that direct cancer cells away from the primary tumour and how the tumour microenvironment contributes to cancer cell migration and metastasis.
We work on a phenomenon known as contact inhibition of locomotion; collisions between migrating cells lead to collapse of actin-driven cell protrusions and a change in the direction of migration. Many cancer cells fail to show contact inhibition of locomotion when confronted to normal cells and this switch to attractive migratory behaviour has been suggested to underlie invasive metastasis. We have shown that EphB receptors are upregulated in metastatic prostate cancer cells and are functionally required for attractive migration after contact with stromal fibroblasts and endothelial cells.
My group continues to focus on how Eph-ephrin signalling regulates cell migration and cell-cell interactions in the context of cancer and wound healing.
1/02/07 → 1/03/11
1/09/03 → 1/09/06
Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblastsHampton-O'Neil, L., Severn, C., Gurung, S., Cross, S., Nobes, C. & Toye, A., 13 Jun 2019, In : Haematologica. 105, 4, p. 914-924 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile34 Downloads (Pure)
Nobes, C. D., 6 Feb 2017, In : Current Biology. 27, 3, p. R90-R95 6 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile28 Citations (Scopus)220 Downloads (Pure)
Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelializationNunan, R., Campbell, J., Mori, R., Pitulescu, M. E., Jiang, W. G., Harding, K. G., Adams, R. H., Nobes, C. D. & Martin, P. B., 17 Nov 2015, In : Cell Reports. 13, 7, p. 1380–1395 16 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile31 Citations (Scopus)361 Downloads (Pure)