Research Output per year
Personal profile
Research interests
My PhD thesis defined the role of the Streptococcus pneumoniae capsule on pneumococcal interactions with complement factors and phagocytes. Furthermore, we demonstrated that resistance to complement mediated immunity is associated with capsular serotype - relatively invasive strains of pneumococcus are more resistant to complement than weakly invasive strains. This demonstrated one mechanism by which serotype-dependent differences in effects on immunity may explain variation in virulence between pneumococcal strains.
I am currently undertaking research examining trends in adult pneumonia, specifically how S. pneumoniae disease may be changing in response to vaccination and the subsequent consequences for healthcare delivery. I am interested in respiratory infection and the consequences of acute viral and bacterial infection for affected individuals, as well as improving clinical care and outcomes for this patient group.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms.
Hyams, C., Camberlein, E., Cohen, JM., Bax, K. & Brown, JS., Feb 2010, In : Infection and Immunity.Research output: Contribution to journal › Article (Academic Journal)
Effects of Streptococcus pneumoniae strain background on complement resistance.
Hyams, C., Opel, S., Hanage, W., Yuste, J., Bax, K., Henriques-Normark, B., Spratt, BG. & Brown, JS., 2011, In : PLoS ONE.Research output: Contribution to journal › Article (Academic Journal)
Estimating the COVID-19 epidemic trajectory and hospital capacity requirements in South West England: a mathematical modelling framework
Booton, R. D., MacGregor, L., Vass, L., Looker, K. J., Hyams, C., Bright, P. D., Harding, I., Lazarus, R., Hamilton, F., Lawson, D., Danon, L., Pratt, A., Wood, R., Brooks-Pollock, E. & Turner, K. M. E., 12 Jun 2020, (Submitted)Research output: Other contribution
Prizes
RCP Turner-Warwick Lectureship 2020
Hyams, Catherine (Recipient), 2020
Prize: Prizes, Medals, Awards and Grants
BALR Young Scientist Award
Hyams, Catherine (Recipient), 2008
Prize: Prizes, Medals, Awards and Grants