Projects per year
My PhD thesis defined the role of the Streptococcus pneumoniae capsule on pneumococcal interactions with complement factors and phagocytes. This demonstrated that resistance to complement mediated immunity is associated with capsular serotype, showing relatively invasive strains of pneumococcus are more resistant to complement-mediated immunity.
I undertake research examining trends in adult pneumonia, and am the Principal Investigator for The Avon CAP study. This study seeks to determine the burden of adult acute respiratory disease and assess how the emergence of COVID-19 may lead to changes in adult respiratory disease. I am particularly interested in how S. pneumoniae disease may be changing in response to COVID-19 and pneumococcal vaccination, as well as determining the consequences of acute viral and bacterial infection for patients and improving outcomes for these patients.
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1/10/20 → 1/10/23
Effectiveness of BNT162b2 and ChAdOx1 nCoV-19 COVID-19 vaccination at preventing hospitalisations in people aged at least 80 years: a test-negative, case-control studyHyams, C., Marlow, R. D., Maseko, Z., King, J. N., Ward, L., Fox, K., Heath, R., Turner, A., Friedrich, Z., Morrison, L., Ruffino, G., Antico, R. S., Adegbite, D. S., Szasz-Benczur, Z., Garcia Gonzalez, M., Oliver, J. L., Danon, L. & Finn, A. H. R., Nov 2021, In: The Lancet Infectious Diseases. 21, 11, p. 1539-1548 10 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review9 Citations (Scopus)
The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms.Hyams, C., Camberlein, E., Cohen, JM., Bax, K. & Brown, JS., Feb 2010, In: Infection and Immunity.
Research output: Contribution to journal › Article (Academic Journal) › peer-review242 Citations (Scopus)
Hyams, C., Opel, S., Hanage, W., Yuste, J., Bax, K., Henriques-Normark, B., Spratt, BG. & Brown, JS., 2011, In: PLoS ONE.
Research output: Contribution to journal › Article (Academic Journal) › peer-review19 Citations (Scopus)