Photo of Catherine Hyams

Dr Catherine Hyams

MBBS, PhD, BSc

  • BS10 5NB

20062020

Research output per year

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Personal profile

Research interests

My PhD thesis defined the role of the Streptococcus pneumoniae capsule on pneumococcal interactions with complement factors and phagocytes. Furthermore, we demonstrated that resistance to complement mediated immunity is associated with capsular serotype - relatively invasive strains of pneumococcus are more resistant to complement than weakly invasive strains. This demonstrated one mechanism by which serotype-dependent differences in effects on immunity may explain variation in virulence between pneumococcal strains.

I am currently undertaking research examining trends in adult pneumonia, specifically how S. pneumoniae disease may be changing in response to vaccination and the subsequent consequences for healthcare delivery. I am interested in respiratory infection and the consequences of acute viral and bacterial infection for affected individuals, as well as improving clinical care and outcomes for this patient group. 

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Research Output

  • 27 Article (Academic Journal)
  • 1 Chapter in a book
  • 1 Review article (Academic Journal)
  • 1 Other contribution

The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms.

Hyams, C., Camberlein, E., Cohen, JM., Bax, K. & Brown, JS., Feb 2010, In : Infection and Immunity.

Research output: Contribution to journalArticle (Academic Journal)

Effects of Streptococcus pneumoniae strain background on complement resistance.

Hyams, C., Opel, S., Hanage, W., Yuste, J., Bax, K., Henriques-Normark, B., Spratt, BG. & Brown, JS., 2011, In : PLoS ONE.

Research output: Contribution to journalArticle (Academic Journal)

Prizes

RCP Turner-Warwick Lectureship 2020

Hyams, Catherine (Recipient), 2020

Prize: Prizes, Medals, Awards and Grants

BALR Young Scientist Award

Hyams, Catherine (Recipient), 2008

Prize: Prizes, Medals, Awards and Grants

BTS Clinical Grand Round

Hyams, Catherine (Recipient), 2019

Prize: Prizes, Medals, Awards and Grants