Dr Celia L Gregson

FRCP, B.Med.Sci., M.B.,B.S.(Nott.), M.R.C.P.(UK), MSc, CCT, PhD

  • BS10 5NB

19982020

Research output per year

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Research Output

  • 60 Article (Academic Journal)
  • 2 Chapter in a book
  • 1 Comment/debate (Academic Journal)
  • 1 Review article (Academic Journal)
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Article (Academic Journal)
2020

Chronic comorbidities in children and adolescents with perinatally acquired HIV infection in sub-Saharan Africa in the era of antiretroviral therapy

Frigati, L., Ameyan, W., Cotton, M. F., Gregson, C. L., Hoare, J., Jao, J., Majonga, E., Myer, L., Penazzato, M., Rukuni, R., Rowland-Jones, S., Zar, H. J. & Ferrand, R. A., 30 Apr 2020, In : Lancet Child and Adolescent Health.

Research output: Contribution to journalArticle (Academic Journal)

Hip fractures in South Africa: mortality outcomes over 12 months post fracture

Paruk, F., Matthews, G., Gregson, C. L. & Cassim, B., 20 Apr 2020, (Accepted/In press) In : Archives of Osteoporosis.

Research output: Contribution to journalArticle (Academic Journal)

Hip fractures in South Africa: mortality outcomes over 12 months post-fracture

Paruk, F., Matthews, G., Gregson, C. L. & Cassim, B., 19 May 2020, In : Archives of Osteoporosis. 15, 1, p. 76

Research output: Contribution to journalArticle (Academic Journal)

How does deprivation influence secondary care costs after hip fracture?

Glynn, J. D., Hollingworth, W., Bhimjiyani, A., Ben-Shlomo, Y. & Gregson, C. L., 2 Apr 2020, In : Osteoporosis International. 2020

Research output: Contribution to journalArticle (Academic Journal)

Individuals with High Bone Mass have increased progression of radiographic and clinical features of knee osteoarthritis.

Hartley, A., Hardcastle, S. A., Paternoster, L., McCloskey, E., Poole, K. E. S., Javaid, M. K., Aye, M., Moss, K., Granell, R., Gregory, J., Williams, M., Tobias, J. H. & Gregson, C. L., 1 Sep 2020, In : Osteoarthritis and Cartilage. p. 1180-1190 11 p.

Research output: Contribution to journalArticle (Academic Journal)

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

Loh, N. Y., Minchin, JE., Pinnick, K. E., Verma, M., Todorčević, M., Denton, N., El-Sayed Moustafa, J. S., Kemp, J. P., Gregson, C. L., Evans, D., Neville, M. J., Small, K. S., McCarthy, M. I., Mahajan, A., Rawls, J. F., Karpe, F. & Christodoulides, C., 3 Jun 2020, In : Nature Communications. (2020) 11, 15 p., 2797.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
23 Downloads (Pure)

The IMpact of Vertical HIV infection on child and Adolescent Skeletal development in Harare, Zimbabwe (IMVASK Study): a protocol for a prospective cohort study

Rukuni, R., Gregson, C. L., Kahari, C., Kowo, F., McHugh, G., Munyati, S., Mujuru, H., Ward, K., Filteau, S., Rehman, A. M. & Ferrand, R. A., 9 Feb 2020, In : BMJ Open. 10, 2, 10 p., e031792.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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74 Downloads (Pure)
2019

An atlas of genetic influences on osteoporosis in humans and mice

the 23 and Me Research Team, Morris, J. A., Kemp, J. P., Youlten, S. E., Laurent, L., Logan, J. G., Chai, R. C., Vulpescu, N. A., Forgetta, V., Kleinman, A., Mohanty, S. T., Sergio, C. M., Quinn, J., Nguyen-Yamamoto, L., Luco, A. L., Vijay, J., Simon, M. M., Pramatarova, A., Medina-Gomez, C., Trajanoska, K. & 31 others, Ghirardello, E. J., Butterfield, N. C., Curry, K. F., Leitch, V. D., Sparkes, P. C., Adoum, A. T., Mannan, N. S., Komla-Ebri, D. S. K., Pollard, A. S., Dewhurst, H. F., Hassall, T. A. D., Beltejar, M. J. G., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., McCreight, J. C., Huber, K. E., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Wilson, C. H., Cooper, C., Tobias, J. H., Gregson, C. L., Adams, D. J. & Evans, D. M., Feb 2019, In : Nature Genetics. 51, p. 258–266 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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90 Citations (Scopus)
215 Downloads (Pure)

A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis

Brown, M. A., Hammond, C., Kemp, J. P., Duncan, E. L. & AOGC Consortium, 16 Sep 2019, In : Journal of Bone and Mineral Research. 40 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Downloads (Pure)
Open Access
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6 Citations (Scopus)
172 Downloads (Pure)

Inequity in rehabilitation interventions after hip fracture: a systematic review

Sheehan, K., Fitzgerald, L., Hatherley, S., Potter, C., Ayis, S., Martin, F., Gregson, C., Cameron, I., Beaupre, L., Wyatt, D., Milton-Cole, R., DiGiorgio, S. & Sackley, C., Jul 2019, In : Age and Ageing. 48, 4, p. 489-497 9 p., afz031.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
67 Downloads (Pure)

Management of fracture risk in Parkinson's: A revised algorithm and focused review of treatments

Henderson, E., Lyell, V., Bhimjiyani, A., Amin, J., Kobylecki, C. & Gregson, C., 8 Apr 2019, In : Parkinsonism and Related Disorders. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
66 Downloads (Pure)
Open Access
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121 Downloads (Pure)

Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe

Gregson, C., Hartley, A., Majonga, E., McHugh, G., Crabtree, N., Rukuni, R., Bandason, T., Mukwasi-Kahari, C., Ward, K., Mujuru, H. & Ferrand, R. A., 1 Aug 2019, In : Bone. 125, p. 96-102 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
204 Downloads (Pure)
2018

Disability, social functioning and school inclusion among older children and adolescents living with HIV in Zimbabwe

Rukuni, R., McHugh, G., Majonga, E., Kranzer, K., Mujuru, H., Munyati, S., Nathoo, K., Gregson, C. L., Kuper, H. & Ferrand, R. A., 1 Feb 2018, In : Tropical Medicine and International Health. 23, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
225 Downloads (Pure)

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes

Gregson, C. L., Newell, F., Leo, P. J., Clark, G. R., Paternoster, L., Marshall, M., Forgetta, V., Morris, J. A., Ge, B., Bao, X., Duncan Bassett, J. H., Williams, G. R., Youlten, S. E., Croucher, P. I., Davey Smith, G., Evans, D. M., Kemp, J. P., Brown, M. A., Tobias, J. H. & Duncan, E. L., 1 Sep 2018, In : Bone. 114, p. 62-71 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
195 Downloads (Pure)
Open Access
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5 Citations (Scopus)
137 Downloads (Pure)
Open Access
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2 Citations (Scopus)
212 Downloads (Pure)
Open Access
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7 Citations (Scopus)
292 Downloads (Pure)

The Impact of Vitamin D Supplementation on Musculoskeletal Health Outcomes in Children, Adolescents, and Young Adults living with HIV: A Systematic Review

Penner, J., Ferrand, R., Richards, C., Ward, K., Burns, J. & Gregson, C., 15 Nov 2018, In : PLoS ONE. 13, 11, 25 p., e0207022.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
216 Downloads (Pure)
2017

DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort

Faber, B. G., Baird, D., Gregson, C. L., Gregory, J. S., Barr, R. J., Aspden, R. M., Lynch, J., Nevitt, M. C., Lane, N. E., Orwoll, E., Tobias, J. H. & Osteoporotic Fractures in Men (MrOS) Study Research Group, Dec 2017, In : Osteoarthritis and Cartilage. 25, 12, p. 2031-2038 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
196 Downloads (Pure)
Open Access
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62 Downloads (Pure)

High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index

Gregson, C. L., Hardcastle, S. A., Murphy, A., Faber, B., Fraser, W. D., Williams, M., Davey Smith, G. & Tobias, J. H., Jan 2017, In : Bone. 97, p. 306-313 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
251 Downloads (Pure)

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

Kemp, J. P., Medina-Gomez, C., Forgetta, V., Warrington, N. M., Youlten, S. E., Zheng, J., Gregson, C. L., Grundberg, E., Trajanoska, K., Logan, J. G., Pollard, A. S., Sparkes, P. C., Ghirardello, E. J., Leitch, V. D., Butterfield, N. C., Komla-Ebri, D., Adoum, A-T., Curry, K. F., White, J. K., Kussy, F. & 14 others, Greenlaw, K. M., Xu, C., Harvey, N. C., Cooper, C., Greenwood, C. M. T., Maurano, M. T., Kaptoge, S., Rivadeneira, F., Tobias, J. H., Croucher, P. I., Ackert-Bicknell, C. L., Bassett, J. H. D., Richards, J. B. & Evans, D. M., 1 Oct 2017, In : Nature Genetics. 49, p. 1468–1475 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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120 Citations (Scopus)
917 Downloads (Pure)

Letter regarding 'Does a bit of alcohol turn off inflammation and improve health?'

Gregson, C. L. & Zuccolo, L., 19 Jan 2017, In : Age and Ageing. 46, 1, p. 158-159 2 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Self-perception of fracture risk: what can it tell us?

Compston, J. E., Wyman, A., Siris, E. S., Adachi, J. D., Chapurlat, R., Díez-Pérez, A., LaCroix, A. Z., Nieves, J. W., Netelenbos, J. C., Pfeilschifter, J., Rossini, M., Roux, C., Saag, K. G., Silverman, S., Watts, N. B., Greenspan, S. L., March, L., Gregson, C. L., Dennison, E. M. & Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators, 31 Aug 2017, In : Osteoporosis International.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
202 Downloads (Pure)

UK clinical guideline for the prevention and treatment of osteoporosis

Compston, J., Cooper, A., Cooper, C., Gittoes, N., Gregson, C., Harvey, N., Hope, S., Kanis, J. A., McCloskey, E. V., Poole, K. E. S., Reid, D. M., Selby, P., Thompson, F., Thurston, A., Vine, N. & National Osteoporosis Guideline Group (NOGG), Dec 2017, In : Archives of Osteoporosis. 12, 1, p. 43

Research output: Contribution to journalArticle (Academic Journal)

232 Citations (Scopus)
2016
Open Access
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8 Citations (Scopus)
186 Downloads (Pure)

Fracture risk and bone health following a stroke are inadequately considered by physicians: A UK survey of practice

Gaskell, N., Choulerton, J., Shaw, L. & Gregson, C., Dec 2016, In : European Geriatric Medicine. 7, 6, p. 547–550 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
262 Downloads (Pure)
Open Access
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171 Downloads (Pure)
2015

Individuals with high bone mass have an increased prevalence of radiographic knee osteoarthritis

Hardcastle, S. A., Dieppe, P., Gregson, C. L., Arden, N. K., Spector, T. D., Hart, D. J., Edwards, M. H., Dennison, E. M., Cooper, C., Sayers, A., Williams, M., Davey Smith, G. & Tobias, J. H., Feb 2015, In : Bone. 71, p. 171-9 9 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7years

Moon, R. J., Cole, Z. A., Crozier, S. R., Curtis, E. M., Davies, J. H., Gregson, C. L., Robinson, S. M., Dennison, E. M., Godfrey, K. M., Inskip, H. M., Cooper, C., Harvey, N. C. & The Southampton Women's Survey Study Group, 20 Feb 2015, In : Bone.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

Loh, N. Y., Neville, M. J., Marinou, K., Hardcastle, S. A., Fielding, B. A., Duncan, E. L., McCarthy, M. I., Tobias, J. H., Gregson, C. L., Karpe, F. & Christodoulides, C., 3 Feb 2015, In : Cell Metabolism. 21, 2, p. 262-72 11 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass cases

Gregson, C. L., Wheeler, L., Hardcastle, S. A., Appleton, L. H., Addison, K. A., Brugmans, M., Clark, G. R., Ward, K., Paggiosi, M., Stone, M., Thomas, J., Agarwal, R., Poole, K., McCloskey, E., Fraser, W. D., Williams, E., Bullock, A. N., Smith, G. D., Brown, M. A., Tobias, J. H. & 1 others, Duncan, E. L., 8 Sep 2015, In : Journal of Bone and Mineral Research. 31, 3, p. 640-649 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
283 Downloads (Pure)

Osteoarthritis and bone mineral density: are strong bones bad for joints?

Hardcastle, S. A., Dieppe, P., Gregson, C. L., Davey Smith, G. & Tobias, J. H., 2015, In : BoneKEy Reports. 4, p. 624

Research output: Contribution to journalArticle (Academic Journal)

Severe polyarthritis secondary to zolendronic acid: a case report and literature review

White, S. L., Jacob, A., Gregson, C. & Bhalla, A., 3 Jul 2015, In : Clinical Cases in Mineral and Bone Metabolism. 12, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Zheng, H-F., Forgetta, V., Hsu, Y-H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C-T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., Eriksson, J. & 31 others, Kwan, T., Jhamai, M., Trajanoska, K., Memari, Y., Min, J., Huang, J., Danecek, P., Wilmot, B., Li, R., Chou, W-C., Mokry, L. E., Moayyeri, A., Claussnitzer, M., Cheng, C-H., Cheung, W., Medina-Gómez, C., Ge, B., Chen, S-H., Choi, K., Oei, L., Fraser, J., Kraaij, R., Hibbs, M. A., Gregson, C. L., Paquette, D., Kemp, J. P., Sayers, A., Davey-Smith, G., Timpson, N. J., Evans, D. M. & AOGC Consortium, 1 Oct 2015, In : Nature. 526, 7571, p. 112-117 6 p.

Research output: Contribution to journalArticle (Academic Journal)

219 Citations (Scopus)
2014

Assessment and management of fracture risk in patients with Parkinson's disease

Lyell, V., Henderson, E., Devine, M. & Gregson, C., 18 Sep 2014, In : Age and Ageing.

Research output: Contribution to journalArticle (Academic Journal)

Atypical Femoral Fracture in Osteoporosis Pseudoglioma Syndrome Associated With Two Novel Compound Heterozygous Mutations in LRP5

Alonso, N., Soares, D. C., McCloskey, E., Summers, G. D., Ralston, S. H. & Gregson, C. L., 10 Nov 2014, In : Journal of Bone and Mineral Research. 30, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Elevated circulating sclerostin concentrations in individuals with High Bone Mass, with and without LPR5 mutations

Gregson, C. L., Poole, K., McCloskey, EV., Duncan, EL., Rittweger, J., Fraser, WD., Smith, GD. & Tobias, J. H., 2014, (Accepted/In press) In : Journal of Clinical Endocrinology and Metabolism.

Research output: Contribution to journalArticle (Academic Journal)

Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations

Gregson, C. L., Poole, K. E. S., McCloskey, E. V., Duncan, E. L., Rittweger, J., Fraser, W. D., Smith, G. D. & Tobias, J. H., Aug 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 8, p. 2897-907 11 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Jump power and force have distinct associations with cortical bone parameters: Findings from a population enriched by individuals with high bone mass

Hardcastle, S. A., Gregson, C. L., Rittweger, J., Crabtree, N., Ward, K. & Tobias, J. H., 1 Jan 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 1, p. 266-275 10 p., 99(1).

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Osteophytes, enthesophytes, and high bone mass: a bone-forming triad with potential relevance in osteoarthritis

Hardcastle, S. A., Dieppe, P., Gregson, C. L., Arden, N. K., Spector, T. D., Hart, D. J., Edwards, M. H., Dennison, E. M., Cooper, C., Williams, M., Davey Smith, G. & Tobias, J. H., Sep 2014, In : Arthritis and Rheumatology. 66, 9, p. 2429-39 11 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Osteophytes, enthesophytes and High Bone Mass; A bone-forming triad with relevance for osteoarthritis >

Hardcastle, S. A., Dieppe, P. A., Gregson, C. L., Arden, NK., Spector, T. D., Hart, D. J., Edwards, M. H., Dennison, E. M., Cooper, C., Williams, M., Davey Smith, G. & Tobias, J. H., 2014, (Accepted/In press) In : Arthritis and Rheumatology.

Research output: Contribution to journalArticle (Academic Journal)

Prevalence of radiographic hip osteoarthritis is increased in high bone mass.

Hardcastle, S. A., Dieppe, P., Gregson, C. L., Hunter, D., Thomas, G. E. R., Arden, N. K., Spector, T. D., Hart, D. J., Laugharne, M. J., Clague, G. A., Edwards, M. H., Dennison, E. M., Cooper, C., Williams, M., Davey Smith, G. & Tobias, J. H., 2014, In : Osteoarthritis and Cartilage. 22, 8, p. 1120-8

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Variation in access to community rehabilitation services and length of stay in hospital following a hip fracture: a cross-sectional study

Neuburger, J., Harding, K. A., Bradley, R. J. D., Cromwell, D. A. & Gregson, C. L., 2014, In : BMJ Open. 4, 9, p. e005469

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2013

Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

Gregson, C. L., Paggiosi, M. A., Crabtree, N., Steel, S. A., McCloskey, E., Duncan, E. L., Fan, B., Shepherd, J. A., Fraser, W. D., Smith, G. D. & Tobias, J. H., 1 Feb 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 2, p. 818-828 10 p., 98(2).

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Disease-specific perception of fracture risk and incident fracture rates: GLOW cohort study

Gregson, C. L., Dennison, E. M., Compston, J. E., Adami, S., Adachi, J. D., Anderson, F. A., Boonen, S., Chapurlat, R., Díez-Pérez, A., Greenspan, S. L., Hooven, F. H., Lacroix, A. Z., Nieves, J. W., Netelenbos, J. C., Pfeilschifter, J., Rossini, M., Roux, C., Saag, K. G., Silverman, S., Siris, E. S. & 4 others, Watts, N. B., Wyman, A., Cooper, C. & for the GLOW Investigators, 25 Jul 2013, In : Osteoporosis International.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)