Charlotte A Bradbury

2025

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial.

Heming, N., Bradbury, C. A., Berry, L. R., Hills, T. E., Higgins, A. M. & Arabi, Y., 22 Apr 2025, In: Intensive Care Medicine. 51, 4, p. 665-680 16 p., 154507.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Therapeutic-dose heparin combined with antiplatelets in non-critically ill patients with COVID-19: A secondary analysis of a multiplatform randomized controlled trial

Lother, S., Teng, W., Ayilara, O., Houston, B. L., Rush, B. & Bradbury, C. A., 21 May 2025, (E-pub ahead of print) In: Research and Practice in Thrombosis and Haemostasis. 102893.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial.

Gordon, A. C., Derde, L. P. G., Mouncey, P., Al-Beidh, F., Rowan, K. M., Bradbury, C. A. & Murthy, S., 13 May 2025, (E-pub ahead of print) In: Thorax. 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

2024

A Phase 2 Study of Ianalumab in Patients with Primary Immune Thrombocytopenia Previously Treated with at Least Two Lines of Therapy: Interim Results from VAYHIT3

Kuter, D. J., Gonzalez Lopez, T. J., Trautmann-Grill, K., Rummel, M. J., Choi, P.Y.-I., Borchiellini, A., Ar, M. C., Tran, H., Zhu, T., Yoon, J.-H., Cooper, N., Stauch, T., Tarkun, P., Le Gac, F., Allepuz, A., Urban, P., Lin, R. & Bradbury, C. A., 5 Nov 2024, In: Blood. 144, Supplement 1, p. 710

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19

Godoy, L. C., Neal, M. D., Goligher, E. C., Cushman, M., Houston, B. L., Bradbury, C. A. & al, E., 1 Mar 2024, In: JACC Advances. 3, 3, p. 100780 18 p., 100780.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Real-world use of thrombopoietin receptor agonists for the management of immune thrombocytopenia in adult patients in the United Kingdom: results from the TRAIT study

Bradbury, C. A., 1 Jun 2024, In: British Journal of Haematology. 204, 6, p. 2442-2452 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia

Stimpson, M. L., Wolf, J., Charbit, C., Williams, E. L., Lait, P. J. P., Schewitz-Bowers, L. P., Lee, R. W. J. & Bradbury, C. A., 6 Feb 2024, In: British Journal of Haematology. 204, 2, p. 644-648 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

2023

A consensus viewpoint on the role of direct factor Xa inhibitors in the management of cancer-associated venous thromboembolism in the UK

Cohen, A., Benson, G., Bradbury, C. A., Choudhuri, S., Hutchinson Jones , N., Maraveyas , A., Venugopal , B., Young , A., Chapman , C., McIntyre , S., Burney , D., Pollock, K., Morgan, A., Gabb, P. & Alikhan, R., 23 Jan 2023, (E-pub ahead of print) In: Current Medical Research and Opinion.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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39 Downloads (Pure)

British Society for Haematology guideline for anticoagulant management of pregnant individuals with mechanical heart valves

Bradbury, C. A., 1 Apr 2023, In: British Journal of Haematology. 202, 3, p. 465-478 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

13 Citations (Scopus)

Continuation of Therapeutic Dose Heparin for Critically Ill Patients with COVID-19: REMAP-CAP Randomized Control Trial

Bradbury, C. A., Lawler, P. R., McVerry, B. J. & Zarychanski, R., 31 May 2023, In: Intensive Care Medicine. 49, p. 873-875 3 p.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

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4 Citations (Scopus)

14 Downloads (Pure)

Heterogeneous Treatment Effects of Therapeutic-dose Heparin in Patients Hospitalized for COVID-19

et al., 21 Mar 2023, (E-pub ahead of print) In: JAMA - Journal of the American Medical Association. 329, 13, p. 1066-1077 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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55 Citations (Scopus)

164 Downloads (Pure)

Intravenous Vitamin C for Patients Hospitalized with COVID-19: Two Harmonized Randomized Clinical Trials

Neill K. J., N. K. J. A., Lamontagne, F. & Bradbury, C. A., 14 Nov 2023, In: JAMA - Journal of the American Medical Association. 330, 18, p. 1745-1759 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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27 Citations (Scopus)

72 Downloads (Pure)

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Bradbury, C. A. & Higgins, A. M., 5 Jan 2023, In: JAMA - Journal of the American Medical Association. 329, 1, p. 39-51 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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93 Citations (Scopus)

52 Downloads (Pure)

Managing raised ferritin in Primary Care

Bradbury, C. A., 26 Jul 2023, In: The BMJ. 382, e076750.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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5 Citations (Scopus)

431 Downloads (Pure)

Response to Knight and Nelson‐Piercy ‘Clarity of guidelines concerning the care of pregnant women is lost by the use of de‐sexed language’

Bradbury, C. A., 12 Jul 2023, In: British Journal of Haematology. 202, 2, p. 438-439 2 p.

Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review

Simvastatin in Critically Ill Patients with COVID-19

Bradbury, C. A., 25 Oct 2023, (E-pub ahead of print) In: New England Journal of Medicine. 389, 25, p. 2341-2354 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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35 Citations (Scopus)

48 Downloads (Pure)

2022

Anticoagulation in COVID-19

Bradbury, C. A. & McQuilten, Z., 1 Jan 2022, In: Lancet. 399, 10319, p. 5-7 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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19 Citations (Scopus)

37 Downloads (Pure)

British Society for Haematology Annual Scientific Meeting, ORAL Presentation. 4th April 2022 Title: Real world evidence from the UK ITP Registry on the effectiveness of the immunosuppressive therapies rituximab and mycophenolate mofetil in immune thrombocytopenia

Bradbury, C. A., Apr 2022, BJH.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

REMAP-CAP Writing Committee, 22 Mar 2022, In: JAMA - Journal of the American Medical Association. 327, 13, p. 1247-1259 13 p., 13.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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104 Citations (Scopus)

139 Downloads (Pure)

Incidence of adult primary immune thrombocytopenia in England—An update

UK adult ITP registry, Doobaree, I. U., Conway, K., Mr, H. M., Miah, A., Makris, M., Hill, Q. A., Cooper, N., Bradbury, C. A. & Newland, A. C., 1 Sept 2022, In: European Journal of Haematology. 109, 3, p. 238-249 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

279 Downloads (Pure)

ISTH guidelines for antithrombotic treatment in COVID-19

International Society on Thrombosis and Haemostasis, 19 Sept 2022, In: Journal of Thrombosis and Haemostasis. 20, 10, p. 2214-2225

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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136 Citations (Scopus)

39 Downloads (Pure)

Paradigm shift in ITP treatment patterns in the era of the COVID-19 pandemic opportunity to study real world outcomes from an established platform: Update from the UK Adult ITP registry

Bradbury, C. A., Jul 2022, Journal of Thrombosis and Haemostasis.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

PB2307: A multicenter, randomized, open-label study of romiplostim plus dexamethasone vs dexamethasone in patients with newly diagnosed primary immune thrombocytopenia

Castellano, M. E. M., Bradbury, C. A., Fernández, C. R., Thomas, I., Alvarez-Román, M. T., Canaro, M., Miranda, I. S. C. & al., E., 12 Jun 2022, June 2022 - Volume 6 - S3, EHA2022 Hybrid Congress Abstract Book. S3 ed. Wolters Kluwer, Vol. 6. p. 3967-3969 3 p. (HemaSphere).

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Open Access

Real world evidence from the UK ITP Registry on the effectiveness of the immunosuppressive therapies rituximab and mycophenolate mofetil in immune thrombocytopenia

Bradbury, C. A., Apr 2022, British Journal of Haematology.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

2021

A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia: results of the first HaemSTAR “Flash-Mob” retrospective study incorporating 961 patients

HaemSTAR Collaborators, 3 Dec 2021, In: British Journal of Haematology. 196, 2, p. 433-437 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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7 Citations (Scopus)

48 Downloads (Pure)

CD4+ T cells from patients with glucocorticoid-refractory immune thrombocytopenia have altered cytokine expression

Stimpson, M. L., Wolf, J., Williams, E. L., Lait, P. J. P., Schewitz-Bowers, L. P., Greenwood, R., Pell, J., Thomas, I., Lee, R. W. J. & Bradbury, C. A., 10 Oct 2021, In: British Journal of Haematology. 196, 4, p. 1113-1117 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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4 Citations (Scopus)

41 Downloads (Pure)

COVID-19 and Immunothrombosis: emerging understanding and clinical management

Shaw, R. J., Bradbury, C., Abrams, S. T., Wang, G. & Toh, C. H., 1 Aug 2021, In: British Journal of Haematology. 194, 3, 12 p., 518-529.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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49 Citations (Scopus)

85 Downloads (Pure)

Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

The REMAP-CAP Investigators & Estcourt, L. J., 4 Oct 2021, (E-pub ahead of print) In: JAMA - Journal of the American Medical Association. 326, 17, p. 1690-1702 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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165 Citations (Scopus)

42 Downloads (Pure)

Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14 ⁺⁺CD16 ⁺ intermediate monocytes from a pro-inflammatory to an anti-inflammatory phenotype

Williams, E. L., Stimpson, M. L., Lait, P. J. P., Schewitz-Bowers, L. P., Jones, L., Dhanda, A., Lee, R. W. J. & Bradbury, C. A., 18 Jan 2021, In: British Journal of Haematology. 192, 2, p. 375-384 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

74 Downloads (Pure)

How Effective Are the Immunosuppressive Therapies Rituximab and Mycophenolate Mofetil in Immune Thrombocytopenia? Real World Evidence from the UK ITP Registry

Bradbury, C. A., 5 Nov 2021, In: Blood. 138, Supplement 1

Research output: Contribution to journal › Article (Academic Journal) › peer-review

How effective are the immunosupression therapies rituximab and mycophenolate mofetil? Real world evidence from the UK ITP registry

Bradbury, C. A., Dec 2021, Blood.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

The REMAP-CAP Investigators, 22 Apr 2021, In: New England Journal of Medicine. 384, 16, p. 1491-1502 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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1411 Citations (Scopus)

68 Downloads (Pure)

Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism: A Systematic Review and Meta-Analysis

Bradbury, C. A., Oct 2021, In: Annals of Internal Medicine. 174, 10, p. 1420-1429 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

107 Citations (Scopus)

Long-Term Risk of Major Bleeding after Discontinuing Anticoagulation for Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis

Khan, F., Rahman, A., Carrier, M., Kearon, C. & Bradbury, C. A., 9 Nov 2021, (E-pub ahead of print) In: Thrombosis and Haemostasis.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

164 Downloads (Pure)

Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta-analysis

Khan, F., Bradbury, C. A., Fergusson, D. & al., E., 11 Aug 2021, (E-pub ahead of print) In: Journal of Thrombosis and Haemostasis. 19, 11, p. 2801-2813 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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24 Citations (Scopus)

47 Downloads (Pure)

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

The REMAP-CAP Investigators & Arabi, Y. M., Aug 2021, In: Intensive Care Medicine. 47, 8, p. 867-886 20 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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73 Citations (Scopus)

84 Downloads (Pure)

Mycophenolate Mofetil for First-Line Treatment of Immune Thrombocytopenia

Bradbury, C. A., Ingram, J., Kandiyali, R., Breheny, K. & Greenwood, R., 2 Sept 2021, In: New England Journal of Medicine. 385, 10, p. 885-895 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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79 Citations (Scopus)

205 Downloads (Pure)

Mycophenolate Mofetil for Immune Thrombocytopenia. Reply

Bradbury, C. A., 2 Dec 2021, In: NEJM. 385, 23

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

2 Citations (Scopus)

Should the dose or duration of anticoagulants for the prevention of venous thrombosis be increased in patients with COVID-19 while we are awaiting the results of clinical trials?

Gomez, K., Laffan, M. & Bradbury, C. A., 31 Jan 2021, In: British Journal of Haematology. 192, 3, p. 459-466

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

28 Downloads (Pure)

Tapering and Discontinuation of Thrombopoietin Receptor Agonist Therapy in Patients With Immune Thrombocytopenia: Results From a Modified Delphi Panel

Cooper, N., Hill , Q., Grainger, J., Westwood, J.-P., Bradbury, C. A., Provan, D., Thachil, J., Ramscar, N. & Roy, A., 1 Jul 2021, In: Acta Haematologica. 144, 4, p. 418-426 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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26 Citations (Scopus)

121 Downloads (Pure)

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

The REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators & et al., 26 Aug 2021, In: New England Journal of Medicine. 385, 9, p. 777-789 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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724 Citations (Scopus)

749 Downloads (Pure)

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

ATTACC Investigators, ACTIV-4a Investigators, The REMAP-CAP Investigators & et al., 26 Aug 2021, In: New England Journal of Medicine. 385, 9, p. 790-802 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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710 Citations (Scopus)

122 Downloads (Pure)

2020

A. Bond, C. Bradbury Thromboembolism in adult patients with acute lymphoblastic leukaemia / lymphoma: past and future practice in a tertiary centre BSH2020-PO-176 British Journal of Haematology, June 2020, 189, (Suppl. 1),160

Bradbury, C. A., May 2020, British Journal of Haematology.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

AntiThrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): study design and methodology for an international, adaptive Bayesian randomized controlled trial

Houston, B. L., Bradbury, C. A., Zarychanski, R. & al., E., 1 Oct 2020, In: Clinical Trials. 17, 5, p. 491-500 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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51 Citations (Scopus)

401 Downloads (Pure)

Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

Angus, D. & Bradbury, C. A., 2 Sept 2020, In: JAMA - Journal of the American Medical Association. 324, 13, p. 1317-1329 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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645 Citations (Scopus)

97 Downloads (Pure)

IL-10 and IL-17 Expression by CD4+ T Cells is Altered in Corticosteroid Refractory Immune Thrombocytopenia (ITP)

Stimpson, M. L., Lait, P. J. P., Schewitz-Bowers, L. P., Williams, E. L., Thirlwall , K., Lee, R. W. J. & Bradbury, C. A., 1 Oct 2020, In: Journal of Thrombosis and Haemostasis. 18, 10, p. 2712-2720 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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17 Citations (Scopus)

149 Downloads (Pure)

Letter on: Predicting the Number of Sites Needed to Deliver a Multicentre Clinical Trial Within a Limited Time Frame in the UK

Greenwood, R. J., Pell, J., Foscarini-Cragg, P., Wale, K., Thomas, I. & Bradbury, C. A., 21 Oct 2020, In: Trials. 21, 4 p., 873 (2020).

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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2 Citations (Scopus)

41 Downloads (Pure)

Madeleine Stimpson, Philippa Lait, Lauren Schewitz-Bowers, Emily Williams, Richard Lee. Charlotte A Bradbury. CD4+ T cell expression of IL-10 compared to IL-17 is lower in patients with Immune Thrombocytopenia (ITP) who do not respond clinically to high dose corticosteroid. Presented at ISTH July 2020

Bradbury, C. A., Jun 2020, Journal of Thrombosis and Haemostasis.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Thrombosis in Patients with Myeloma Treated in the Myeloma IX and Myeloma XI Phase III Randomized Controlled Trials

Bradbury, C. A., Craig, Z., Cook, G., Pawlyn, C., Cairns, D. A., Hockaday, A., Paterson, A., Jenner, M. W., Jones, J. R., Drayson, M. T., Owen, R. G., Kaiser, M. F., Gregory, W. M., Davies, F. E., Child, J. A., Morgan, G. J. & Jackson, G., 27 Aug 2020, In: Blood. 136, 9, p. 1091-1104

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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70 Citations (Scopus)

87 Downloads (Pure)

Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study

Shah, A., Donovan, K., McHugh, A., Pandey, M., Aaron, L., Bradbury, C. A., Stanworth, S. J., Alikhan, R., Von Kier, S., Maher, K., Curry, N., Shapiro, S., Rowland, M., Thomas, M., Mason, R., Holland, M., Holmes, T., Ware, M., Gurney, S. & McKechnie, S., 18 Sept 2020, In: Critical Care. 24, 10 p., 561 (2020).

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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99 Citations (Scopus)

105 Downloads (Pure)

Dr Charlotte A Bradbury

Research output

Search results